CO5080759A1 - BIARILACETILENOS AS INHIBITORS OF THE METALOPROTEASE OF MATRIX - Google Patents

BIARILACETILENOS AS INHIBITORS OF THE METALOPROTEASE OF MATRIX

Info

Publication number
CO5080759A1
CO5080759A1 CO97025172A CO97025172A CO5080759A1 CO 5080759 A1 CO5080759 A1 CO 5080759A1 CO 97025172 A CO97025172 A CO 97025172A CO 97025172 A CO97025172 A CO 97025172A CO 5080759 A1 CO5080759 A1 CO 5080759A1
Authority
CO
Colombia
Prior art keywords
matrix
biarilacetilenos
metaloprotease
inhibitors
jpeg
Prior art date
Application number
CO97025172A
Other languages
Spanish (es)
Inventor
Brian R Dixon
Jinshan Chen
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of CO5080759A1 publication Critical patent/CO5080759A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/90Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Compuestos inhibidores de la metaloproteasa de matriz que tienen la fórmula general:<EMI FILE="97025172_1" ID="1" IMF=JPEG >donde R15 es seleccionado entre el grupo que consiste en HOCH2, (n-Pr)2NCH2, CH3CO2CH2, EtOCO2CH2, HO(CH2 )2, CH3 CO2(CH2 )2 , HO2C(CH2)2, OCH(CH2)3, HO(CH2 )4 , 3-HO-Ph, y PhCH2OCH2 ; yR16 es<EMI FILE="97025172_2" ID="2" IMF=JPEG >Y sales farmacéuticamente aceptables de estos.Matrix metalloprotease inhibitor compounds having the general formula: <EMI FILE = "97025172_1" ID = "1" IMF = JPEG> where R15 is selected from the group consisting of HOCH2, (n-Pr) 2NCH2, CH3CO2CH2, EtOCO2CH2, HO (CH2) 2, CH3 CO2 (CH2) 2, HO2C (CH2) 2, OCH (CH2) 3, HO (CH2) 4, 3-HO-Ph, and PhCH2OCH2; and R16 is <EMI FILE = "97025172_2" ID = "2" MFI = JPEG> And pharmaceutically acceptable salts thereof.

CO97025172A 1996-05-15 1997-05-09 BIARILACETILENOS AS INHIBITORS OF THE METALOPROTEASE OF MATRIX CO5080759A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64502896A 1996-05-15 1996-05-15

Publications (1)

Publication Number Publication Date
CO5080759A1 true CO5080759A1 (en) 2001-09-25

Family

ID=24587368

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97025172A CO5080759A1 (en) 1996-05-15 1997-05-09 BIARILACETILENOS AS INHIBITORS OF THE METALOPROTEASE OF MATRIX

Country Status (18)

Country Link
EP (1) EP0912496A1 (en)
JP (1) JP3090957B2 (en)
CN (1) CN1139570C (en)
AR (1) AR007097A1 (en)
AU (1) AU710759B2 (en)
BR (1) BR9709077A (en)
CA (1) CA2253796C (en)
CO (1) CO5080759A1 (en)
HN (1) HN1997000088A (en)
HR (1) HRP970245B1 (en)
ID (1) ID16910A (en)
PA (1) PA8429301A1 (en)
SV (1) SV1997000035A (en)
TN (1) TNSN97084A1 (en)
TW (1) TW381079B (en)
WO (1) WO1997043245A1 (en)
YU (1) YU18697A (en)
ZA (1) ZA974031B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
AR035478A1 (en) * 1999-01-27 2004-06-02 Wyeth Corp AMIDA-HYDROXAMIC ACID, ACETYLLENE, BETA-SULPHONAMIDE AND PHOSPHINIC ACID AS INHIBITORS OF TACE, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
US6326516B1 (en) 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
CA2804918C (en) 2010-07-08 2018-03-06 Kaken Pharmaceutical Co., Ltd. N-hydroxyformamide derivative and medicament containing same
CN106458938A (en) 2014-04-03 2017-02-22 拜耳制药股份公司 Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
CA2944614A1 (en) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases
EP3126339A1 (en) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784701A (en) * 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2112716A1 (en) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Biphenylyl-butyric acid derivs. - anti phlogistics
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
CA2253796A1 (en) 1997-11-20
CN1139570C (en) 2004-02-25
CN1225623A (en) 1999-08-11
HRP970245B1 (en) 2002-06-30
ID16910A (en) 1997-11-20
WO1997043245A1 (en) 1997-11-20
HRP970245A2 (en) 1998-04-30
SV1997000035A (en) 1999-01-14
BR9709077A (en) 1999-08-03
EP0912496A1 (en) 1999-05-06
HN1997000088A (en) 1997-06-18
JPH11511179A (en) 1999-09-28
AU710759B2 (en) 1999-09-30
PA8429301A1 (en) 2000-05-24
AU2938697A (en) 1997-12-05
ZA974031B (en) 1998-02-19
AR007097A1 (en) 1999-10-13
YU18697A (en) 1999-11-22
TW381079B (en) 2000-02-01
CA2253796C (en) 2003-10-28
TNSN97084A1 (en) 2005-03-15
JP3090957B2 (en) 2000-09-25

Similar Documents

Publication Publication Date Title
ES2196190T3 (en) INHIBITORS OF METALOPROTEINASAS MATRICIALES, WITH BIFENLICO HYDROXAMATE.
AR015649A1 (en) INHIBITORS OF PROTEIC ISOPRENYL-TRANSFERS, COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
CO5180581A1 (en) COMPOUNDS FOR THE TREATMENT OF THE ISCHEMIA PHARMACEUTICAL TIONS THAT CONTAIN THEM FOR THE TREATMENT OF THE ISCHEMIA
DE69835518D1 (en) IMIDAZOLYL-CYCLIC ACETALE
CO5690131A1 (en) DERIVATIVES OF ETER BIARILICO PRESENTING ACTIVITY AS INHIBITORS OF THE RECOVERY OF MONOAMINS FOR THE TREATMENT OF CNS DISORDERS
LU91497I2 (en) Rivaroxaban and its pharmaceutically acceptable salts, hydrates, hydrates of these salts and prodrugs
ES2102154T3 (en) THROMBIN INHIBITION.
RU95104885A (en) 1h-indole-3-glyoxylamides inhibiting spla2-mediated fatty acids release, pharmaceutical composition
CO5271665A1 (en) (PIRROLO COMPOUNDS [2,3-D] PYRIMIDINE
BRPI0111116B8 (en) thrombopoietin mimics
YU18999A (en) Substituted tricyclics
CO5080759A1 (en) BIARILACETILENOS AS INHIBITORS OF THE METALOPROTEASE OF MATRIX
CO5271675A1 (en) DECAHIDRO-ISOQUINOLINAS DERIVATIVES, PROCESS FOR THE PREPARATION, COMPOSITION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM
KR880009910A (en) Lipoxygenase inhibitory compounds
ES2153851T3 (en) TREATMENT OF SKIN AND VAGINA ATROPHY.
CO5261552A1 (en) PROCEDURE FOR OBTAINING 1,2,3,4-TETRAHYDROQUINE- LINES 4-CARBOXIAMINO-2-SUBSTITUTED
GT199700037A (en) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF RHINITIS
CO5180578A1 (en) INHIBITORS OF SUBSTITUTED DIHETER METALOPROTEASES THAT ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS CHARACTERIZED BY THE EXCESSIVE ACTIVITY OF THESE ENZYMES
CO5090829A1 (en) ORGANIC COMPOUNDS OF FORMULA I, USED AS INHIBITED RES OF THE PROTEIN OF TRANSFER OF MICROSOUS TRIGLICERIDE AND OF THE APOLIPOPROTEIN B SECRETION.
CO5420196A1 (en) INHIBITING COMPOUNDS OF METALOPROTEASE BIDENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR USE
ES2119094T3 (en) INHIBITION OF DYSFUNCTIONAL UTERINE HEMORRHAGE.
AR018162A1 (en) SUBSTITUTED PIRROLS, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE PREPARATION OF SUCH PHARMACEUTICAL COMPOSITION
EP0865434A4 (en)
KR950016741A (en) How to curb weight gain or induce weight loss
CO5140099A1 (en) CERTAIN SUBSTITUTED CAPROLACTAMAS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND ITS USE IN TUMORS TREATMENT