ECSP11011497A - Radiotrazadores pet para la imagimática del metabolismo y conservación de ácidos grasos - Google Patents

Radiotrazadores pet para la imagimática del metabolismo y conservación de ácidos grasos

Info

Publication number
ECSP11011497A
ECSP11011497A ECSP11011497A ECSP11011497A EC SP11011497 A ECSP11011497 A EC SP11011497A EC SP11011497 A ECSP11011497 A EC SP11011497A EC SP11011497 A ECSP11011497 A EC SP11011497A
Authority
EC
Ecuador
Prior art keywords
fatty acids
metabolism
radiotrazers
imagimatics
conservation
Prior art date
Application number
Other languages
English (en)
Inventor
Robert H Mach
Robert John Gropler
Zhude Tu
Pilar Herrero
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of ECSP11011497A publication Critical patent/ECSP11011497A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se describen moléculas del análogo de ácido graso (FAA) que comprenden radionúclidos, de emisión de positrones, sales de éstos, y FAA-triglicéridos. Se describen, además, los métodos de síntesis, y métodos de distribución de imágenes y metabolismo de los ácidos grasos y triglicéridos de ácidos grasos.
ECSP11011497 2009-05-04 2011-12-01 Radiotrazadores pet para la imagimática del metabolismo y conservación de ácidos grasos ECSP11011497A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17506509P 2009-05-04 2009-05-04

Publications (1)

Publication Number Publication Date
ECSP11011497A true ECSP11011497A (es) 2012-03-30

Family

ID=43050827

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP11011497 ECSP11011497A (es) 2009-05-04 2011-12-01 Radiotrazadores pet para la imagimática del metabolismo y conservación de ácidos grasos

Country Status (19)

Country Link
US (1) US20120100073A1 (es)
EP (1) EP2427218A4 (es)
JP (1) JP2012526129A (es)
KR (1) KR20120060943A (es)
CN (1) CN102421454A (es)
AU (1) AU2010246010A1 (es)
BR (1) BRPI1014538A2 (es)
CA (1) CA2760334A1 (es)
CL (1) CL2011002753A1 (es)
CO (1) CO6460756A2 (es)
CR (1) CR20110637A (es)
EA (1) EA201171355A1 (es)
EC (1) ECSP11011497A (es)
IL (1) IL216124A0 (es)
MX (1) MX2011011743A (es)
NO (1) NO20111663A1 (es)
SG (1) SG175430A1 (es)
WO (1) WO2010129572A2 (es)
ZA (1) ZA201108053B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201021369D0 (en) * 2010-12-16 2011-01-26 Ge Healthcare Ltd Radioiodinated fatty acids
WO2014030650A1 (ja) 2012-08-20 2014-02-27 大塚製薬株式会社 糖代謝能の測定方法及びそれに使用する組成物
KR20150132301A (ko) * 2013-03-15 2015-11-25 오츠카 세이야쿠 가부시키가이샤 지방산 연소에 의한 인슐린 저항성의 측정 방법, 및 그에 사용하는 조성물
US20160185735A1 (en) * 2013-08-12 2016-06-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acid analogs and their use
US10457642B2 (en) 2015-05-04 2019-10-29 The Trustees Of The University Of Pennsylvania 211-astatine containing radiotherapeutics for the treatment of cancer
EP3825302A4 (en) 2018-07-20 2022-05-04 Astellas Pharma Inc. FATTY ACID DERIVATIVE LABELED WITH POSITRON-emitting radionuclide
WO2021145403A1 (ja) * 2020-01-17 2021-07-22 アステラス製薬株式会社 陽電子放出核種で標識された脂肪酸誘導体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2846491A (en) * 1955-12-13 1958-08-05 Air Reduction Reactions of sodium acetylide with alkyl halides
EP0136879A3 (en) * 1983-09-30 1987-01-07 Yamanouchi Pharmaceutical Co., Ltd. Fatty acid derivatives and processes of producing them
EP0327523B1 (en) * 1988-02-03 1992-06-17 Washington University Novel fatty acid analog enzyme substrates
ES2088480T3 (es) * 1990-10-12 1996-08-16 Univ Washington Sustratos de enzimas analogos de acidos grasos sustituidos con azido.
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
US5747537A (en) * 1995-09-05 1998-05-05 Washington University Method of inhibiting parasitic activity
ATE353019T1 (de) * 1995-12-01 2007-02-15 Molecular Insight Pharm Inc Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung
JP4415216B2 (ja) * 2002-02-01 2010-02-17 大日本住友製薬株式会社 ２−フランカルボン酸ヒドラジド化合物及びそれを含有する医薬組成物
WO2004093650A2 (en) * 2003-04-17 2004-11-04 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
CN1886362B (zh) * 2003-07-24 2010-10-13 皇后医学中心 烷基化剂的制备和用途
JP4455413B2 (ja) * 2004-06-11 2010-04-21 キヤノン株式会社 ビニル基、エステル基、カルボキシル基並びにスルホン酸基を有するポリヒドロキシアルカン酸並びにその製造方法

Also Published As

Publication number Publication date
CL2011002753A1 (es) 2012-07-13
EA201171355A1 (ru) 2012-05-30
US20120100073A1 (en) 2012-04-26
WO2010129572A3 (en) 2010-12-29
CR20110637A (es) 2012-02-09
CA2760334A1 (en) 2010-11-11
KR20120060943A (ko) 2012-06-12
CO6460756A2 (es) 2012-06-15
ZA201108053B (en) 2012-07-25
WO2010129572A2 (en) 2010-11-11
AU2010246010A1 (en) 2011-11-17
IL216124A0 (en) 2012-01-31
MX2011011743A (es) 2011-11-29
NO20111663A1 (no) 2011-12-02
EP2427218A2 (en) 2012-03-14
BRPI1014538A2 (pt) 2016-04-05
JP2012526129A (ja) 2012-10-25
CN102421454A (zh) 2012-04-18
EP2427218A4 (en) 2014-06-18
SG175430A1 (en) 2011-12-29

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