ECSP11011210A - Sal de hemi-fumarato del ácido 1-[4-[1-(4-ciclohexil-3-trifluoro-metil-benciloxi-imino)-etil]-2-etil-bencil]-azetidin-3-carboxílico - Google Patents
Sal de hemi-fumarato del ácido 1-[4-[1-(4-ciclohexil-3-trifluoro-metil-benciloxi-imino)-etil]-2-etil-bencil]-azetidin-3-carboxílicoInfo
- Publication number
- ECSP11011210A ECSP11011210A EC2011011210A ECSP11011210A ECSP11011210A EC SP11011210 A ECSP11011210 A EC SP11011210A EC 2011011210 A EC2011011210 A EC 2011011210A EC SP11011210 A ECSP11011210 A EC SP11011210A EC SP11011210 A ECSP11011210 A EC SP11011210A
- Authority
- EC
- Ecuador
- Prior art keywords
- etil
- hemi
- azetidin
- imino
- trifluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere a una sal de hemi-fumarato del ácido 1-(4-{1-[(E)-4-ciclohexil-3-trifluoro-metil-benciloxi-imino]-etil}-2-etil-bencil)-azetidin-3-carboxílico (Compuesto I), a composiciones farmacéuticas que comprenden esta sal, a procesos para formar esta sal, y a su uso en un tratamiento médico. En adición, la presente invención también se refiere a nuevas formas polimórficas de la forma de sal de hemi-fumarato del Compuesto I, así como a composiciones farmacéuticas que comprenden estas formas polimórficas, a procesos para obtenerlas, y a su uso en un tratamiento médico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20305308P | 2008-12-18 | 2008-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP11011210A true ECSP11011210A (es) | 2011-08-31 |
Family
ID=42236293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2011011210A ECSP11011210A (es) | 2008-12-18 | 2011-07-15 | Sal de hemi-fumarato del ácido 1-[4-[1-(4-ciclohexil-3-trifluoro-metil-benciloxi-imino)-etil]-2-etil-bencil]-azetidin-3-carboxílico |
Country Status (36)
Country | Link |
---|---|
US (6) | US20120115840A1 (es) |
EP (2) | EP2676953B1 (es) |
JP (1) | JP5627597B2 (es) |
KR (5) | KR101885052B1 (es) |
CN (2) | CN102256943A (es) |
AR (3) | AR074694A1 (es) |
AU (1) | AU2009335924B2 (es) |
BR (1) | BRPI0923176B8 (es) |
CA (2) | CA2951479A1 (es) |
CL (1) | CL2011001490A1 (es) |
CO (1) | CO6390104A2 (es) |
CY (2) | CY1114662T1 (es) |
DK (2) | DK2379497T3 (es) |
EC (1) | ECSP11011210A (es) |
ES (2) | ES2436197T3 (es) |
HK (1) | HK1159631A1 (es) |
HR (2) | HRP20131106T1 (es) |
HU (1) | HUE034819T2 (es) |
IL (3) | IL294514A (es) |
JO (1) | JO2894B1 (es) |
LT (1) | LT2676953T (es) |
MA (1) | MA32961B1 (es) |
MX (1) | MX2011006609A (es) |
MY (1) | MY152669A (es) |
NZ (1) | NZ593061A (es) |
PE (2) | PE20142374A1 (es) |
PL (2) | PL2676953T3 (es) |
PT (2) | PT2379497E (es) |
RS (2) | RS56110B1 (es) |
RU (1) | RU2518114C3 (es) |
SG (1) | SG171785A1 (es) |
SI (2) | SI2379497T1 (es) |
TW (2) | TWI591055B (es) |
UY (1) | UY32330A (es) |
WO (1) | WO2010080409A1 (es) |
ZA (1) | ZA201103709B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112013017302B1 (pt) | 2011-01-07 | 2021-12-07 | Novartis Ag | Composição farmacêutica em fase sólida |
WO2012095853A1 (en) | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Modified release formulations comprising sip receptor modulators |
AU2015246036A1 (en) * | 2014-04-10 | 2016-10-13 | Novartis Ag | S1P modulator immediate release dosage regimen |
WO2015155711A1 (en) | 2014-04-10 | 2015-10-15 | Novartis Ag | Immunosuppressant formulation |
WO2016135644A1 (en) | 2015-02-26 | 2016-09-01 | Novartis Ag | Treatment of autoimmune disease in a patient receiving additionally a beta-blocker |
US20190047951A1 (en) | 2016-01-04 | 2019-02-14 | Auspex Pharmaceuticals, Inc. | Azetidine modulators of the sphingosine 1-phosphate receptor |
US11958805B2 (en) * | 2017-03-09 | 2024-04-16 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
AU2018341136A1 (en) * | 2017-09-27 | 2020-03-12 | Novartis Ag | Parenteral formulation comprising siponimod |
US11390583B2 (en) | 2017-09-27 | 2022-07-19 | Dr. Reddy's Laboratories Limited | Process for preparation of Siponimod, its salts and solid state forms thereof |
MX2020007326A (es) * | 2017-09-29 | 2020-09-07 | Novartis Ag | Regimen de dosificacion de siponimod. |
RU2020114750A (ru) | 2017-09-29 | 2021-10-29 | Новартис Аг | Схема введения доз сипонимода |
EP3743405B1 (en) | 2018-01-22 | 2023-11-15 | Teva Pharmaceuticals International GmbH | Crystalline siponimod fumaric acid and polymorphs thereof |
CN110776450B (zh) * | 2018-07-27 | 2022-09-27 | 广东东阳光药业有限公司 | 一种辛波莫德晶型及其制备方法 |
CN111484434A (zh) * | 2019-01-29 | 2020-08-04 | 东莞市东阳光仿制药研发有限公司 | 一种辛波莫德晶型及其制备方法 |
WO2020161632A1 (en) * | 2019-02-07 | 2020-08-13 | Dr. Reddy’S Laboratories Limited | Crystalline solid forms of siponimod |
US20220144768A1 (en) * | 2019-02-27 | 2022-05-12 | Dr. Reddy's Laboratories Limited | Solid state forms of siponimod |
EP3972954A1 (en) | 2019-05-21 | 2022-03-30 | Synthon B.V. | Siponimod maleic acid and fumaric acid salt |
AU2020372647A1 (en) | 2019-10-31 | 2022-06-16 | Idorsia Pharmaceuticals Ltd | Combination of a CXCR7 antagonist with an S1P1 receptor modulator |
WO2021240547A2 (en) * | 2020-05-29 | 2021-12-02 | Cipla Limited | Methods for the preparation of sphingosine 1-phosphate receptor modulators and solid forms thereof |
WO2022064007A1 (en) | 2020-09-25 | 2022-03-31 | Synthon B.V. | Siponimod salts and cocrystals |
CN112402610A (zh) * | 2020-11-20 | 2021-02-26 | 睿阜隆(杭州)生物医药有限公司 | 1-磷酸鞘氨醇受体调节剂在制备治疗糖尿病的药物中的新用途 |
WO2022127863A1 (zh) * | 2020-12-16 | 2022-06-23 | 苏州晶云药物科技股份有限公司 | 一种羧酸类化合物半富马酸盐的晶型及其制备方法 |
WO2022199865A1 (en) | 2021-03-26 | 2022-09-29 | Olon S.P.A. | Novel crystalline compound of siponimod hemifumarate |
EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
ATE124217T1 (de) * | 1991-06-04 | 1995-07-15 | Fujisawa Pharmaceutical Co | Vorbeugende/therapeutische zusammensetzung für die pleuropneumonie des schweins. |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
TW225528B (es) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
SK285035B6 (sk) | 1992-10-28 | 2006-05-04 | Genentech, Inc. | Antagonisty rastového faktora vaskulárnych endotelových buniek |
DE69430575T2 (de) * | 1993-06-08 | 2002-10-02 | Hisamitsu Pharmaceutical Co | Iontophoretisches system |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
CA2216796C (en) | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
CA2224435C (en) | 1995-07-06 | 2008-08-05 | Novartis Ag | Pyrrolopyrimidines and processes for the preparation thereof |
US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
DE69725585T2 (de) * | 1996-04-04 | 2004-07-01 | Sankyo Co., Ltd. | Phenylalkylcarbonsäure-derivate |
CA2249446C (en) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
DE69734513T2 (de) | 1996-06-24 | 2006-07-27 | Pfizer Inc. | Phenylamino-substituierte tricyclische derivate zur behandlung hyperproliferativer krankheiten |
EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
AU4342997A (en) | 1996-09-13 | 1998-04-02 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders |
EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
PT1107964E (pt) | 1998-08-11 | 2010-06-11 | Novartis Ag | Derivados de isoquinolina com actividade inibidora da angiogénese |
GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
EP1140173B2 (en) | 1998-12-22 | 2013-04-03 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
PT1165085E (pt) | 1999-03-30 | 2006-10-31 | Novartis Ag | Derivados de ftalazina para tratar doencas inflamatorias |
WO2002053538A1 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US20030216376A1 (en) * | 2002-03-20 | 2003-11-20 | Revital Lifshitz-Liron | Crystalline forms of quetiapine hemifumarate |
US6900206B2 (en) * | 2002-06-20 | 2005-05-31 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives |
DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
MY150088A (en) * | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
WO2004110330A1 (en) | 2003-06-13 | 2004-12-23 | Stephen Dichiera | Adjustable bed support and bed |
AR051444A1 (es) * | 2004-09-24 | 2007-01-17 | Centocor Inc | Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos |
EP2359821A1 (en) * | 2004-11-29 | 2011-08-24 | Novartis AG | Dosage regimen of an s1p receptor agonist |
CN101238099A (zh) * | 2005-08-04 | 2008-08-06 | 诺瓦提斯公司 | 维格列汀的盐 |
GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
US20060223820A1 (en) * | 2006-03-21 | 2006-10-05 | Chemagis Ltd. | Crystalline aripiprazole salts and processes for preparation and purification thereof |
GB0612721D0 (en) * | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
PE20121179A1 (es) * | 2006-11-07 | 2012-09-13 | Novartis Ag | Forma cristalina de hemifumarato de alisquireno |
-
2009
- 2009-12-16 WO PCT/US2009/068143 patent/WO2010080409A1/en active Application Filing
- 2009-12-16 JP JP2011542351A patent/JP5627597B2/ja active Active
- 2009-12-16 US US13/140,478 patent/US20120115840A1/en not_active Abandoned
- 2009-12-16 LT LTEP13177190.9T patent/LT2676953T/lt unknown
- 2009-12-16 KR KR1020187000381A patent/KR101885052B1/ko active IP Right Grant
- 2009-12-16 RU RU2011129222A patent/RU2518114C3/ru active Protection Beyond IP Right Term
- 2009-12-16 MA MA34008A patent/MA32961B1/fr unknown
- 2009-12-16 SG SG2011036886A patent/SG171785A1/en unknown
- 2009-12-16 PE PE2014001111A patent/PE20142374A1/es not_active Application Discontinuation
- 2009-12-16 PT PT97934137T patent/PT2379497E/pt unknown
- 2009-12-16 PL PL13177190T patent/PL2676953T3/pl unknown
- 2009-12-16 CA CA2951479A patent/CA2951479A1/en not_active Abandoned
- 2009-12-16 NZ NZ593061A patent/NZ593061A/xx unknown
- 2009-12-16 CA CA2747437A patent/CA2747437C/en active Active
- 2009-12-16 MX MX2011006609A patent/MX2011006609A/es active IP Right Grant
- 2009-12-16 AR ARP090104917A patent/AR074694A1/es not_active Application Discontinuation
- 2009-12-16 RS RS20170599A patent/RS56110B1/sr unknown
- 2009-12-16 PE PE2011001226A patent/PE20120336A1/es not_active Application Discontinuation
- 2009-12-16 EP EP13177190.9A patent/EP2676953B1/en active Active
- 2009-12-16 CN CN2009801512748A patent/CN102256943A/zh active Pending
- 2009-12-16 UY UY0001032330A patent/UY32330A/es not_active Application Discontinuation
- 2009-12-16 DK DK09793413.7T patent/DK2379497T3/da active
- 2009-12-16 DK DK13177190.9T patent/DK2676953T3/en active
- 2009-12-16 PT PT131771909T patent/PT2676953T/pt unknown
- 2009-12-16 SI SI200930750T patent/SI2379497T1/sl unknown
- 2009-12-16 KR KR1020117016548A patent/KR20110096584A/ko not_active Application Discontinuation
- 2009-12-16 ES ES09793413T patent/ES2436197T3/es active Active
- 2009-12-16 IL IL294514A patent/IL294514A/en unknown
- 2009-12-16 ES ES13177190.9T patent/ES2631203T3/es active Active
- 2009-12-16 BR BRPI0923176A patent/BRPI0923176B8/pt active IP Right Grant
- 2009-12-16 SI SI200931675A patent/SI2676953T1/sl unknown
- 2009-12-16 RS RS20130510A patent/RS53041B/en unknown
- 2009-12-16 KR KR1020167013818A patent/KR20160064245A/ko not_active Application Discontinuation
- 2009-12-16 AU AU2009335924A patent/AU2009335924B2/en active Active
- 2009-12-16 HU HUE13177190A patent/HUE034819T2/en unknown
- 2009-12-16 MY MYPI20112413 patent/MY152669A/en unknown
- 2009-12-16 CN CN201510102280.1A patent/CN104803902A/zh active Pending
- 2009-12-16 IL IL253845A patent/IL253845B/en unknown
- 2009-12-16 PL PL09793413T patent/PL2379497T3/pl unknown
- 2009-12-16 KR KR1020177014691A patent/KR20170062554A/ko not_active Application Discontinuation
- 2009-12-16 KR KR1020167030350A patent/KR20160129915A/ko active Application Filing
- 2009-12-16 EP EP09793413.7A patent/EP2379497B1/en active Active
- 2009-12-17 TW TW103142662A patent/TWI591055B/zh active
- 2009-12-17 JO JO2009488A patent/JO2894B1/en active
- 2009-12-17 TW TW098143443A patent/TWI500603B/zh active
-
2011
- 2011-05-20 ZA ZA2011/03709A patent/ZA201103709B/en unknown
- 2011-05-23 IL IL213071A patent/IL213071A0/en unknown
- 2011-06-17 CL CL2011001490A patent/CL2011001490A1/es unknown
- 2011-06-23 CO CO11079284A patent/CO6390104A2/es not_active Application Discontinuation
- 2011-07-15 EC EC2011011210A patent/ECSP11011210A/es unknown
-
2012
- 2012-01-09 HK HK12100216.4A patent/HK1159631A1/xx unknown
-
2013
- 2013-06-12 US US13/915,941 patent/US20140005162A1/en not_active Abandoned
- 2013-11-20 CY CY20131101026T patent/CY1114662T1/el unknown
- 2013-11-20 HR HRP20131106AT patent/HRP20131106T1/hr unknown
-
2015
- 2015-03-03 US US14/636,248 patent/US20150175536A1/en not_active Abandoned
-
2017
- 2017-06-14 HR HRP20170916TT patent/HRP20170916T1/hr unknown
- 2017-06-22 CY CY20171100669T patent/CY1119037T1/el unknown
- 2017-10-31 US US15/799,235 patent/US20180118678A1/en not_active Abandoned
-
2018
- 2018-07-10 AR ARP180101916 patent/AR112227A2/es unknown
-
2020
- 2020-11-11 US US17/095,052 patent/US20210323915A1/en not_active Abandoned
-
2021
- 2021-03-22 AR ARP210100712A patent/AR121635A2/es unknown
-
2022
- 2022-08-10 US US17/818,889 patent/US20230357142A9/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR121635A2 (es) | Nueva sal y formas cristalinas | |
CL2011002697A1 (es) | Compuestos derivados de 3-[4-(oxo-dihidropiridin)bencil]-1,3-oxazin-ona hidratados, inhibidores 11beta-hsd1; composicion farmaceutica que los comprende; y su uso en el tratamiento de la diabetes | |
CR20110611A (es) | Sales de disacarina, ácido difumárico, ácido di-1-hidroxi-2-naftoico y ácido monobenzoico del 2-(4-((2-amino-4-metil-6-(pentilamino)pirimidin-5-il)metil)fenil) acetato de 4-(dimetilamino)butilo | |
CU20150062A7 (es) | Lactamas n-(heteroarilo sustituido) fusionadas utiles en el tratamiento del crecimiento celular anormal | |
BRPI0911273B8 (pt) | composição farmacêutica compreendendo um inibidor de dpp-iv, bem como processo para sua preparação | |
EA201200550A1 (ru) | Фармацевтические композиции, включающие bi-1356 и метформин | |
EA201071144A1 (ru) | Гетероциклические производные | |
CO6640327A2 (es) | Compuestos de pirazol como inhibidores del receptor sigma | |
CL2011003147A1 (es) | Compuestos derivados de n-(1-4-(1h-pirazol-5-il)ftalazina-1-il) piperidina-4-il) benzamida; composicion farmaceutica que los contiene, utiles como antagonista de la trayectoria de hedgehog, en el tratamiento del cancer. | |
CO6531458A2 (es) | Nuevos compuestos de espiropiperidina | |
CR20120296A (es) | Nuevos compuestos de espiropiperidina | |
CY1118976T1 (el) | Κρυσταλλικες τροποποιησεις της (1r,2r)-3-(3-διμεθυλαμινο-1-αιθυλ-2-μεθυλ-προπυλ)-φαινολης | |
CR20110269A (es) | Lactamas como inhibidores de beta secretasa | |
UY31627A1 (es) | Nuevas formas cristalinas del ácido 4-[4-(2-adamantilcarbamoíl)-5-ter-butil-pirazol-1-il]benzoico | |
CO6741154A2 (es) | Compuestos de triazolopiridina | |
IT1391866B1 (it) | Composizione iniettabile di polinucleotidi per il trattamento di patologie osteoarticolari. | |
CY1124505T1 (el) | Κρυσταλλικες μορφες βιλαστινης και μεθοδοι παρασκευης αυτων | |
ECSP11011323A (es) | Método o sistema que usa biomarcadores para el seguimiento de un tratamiento. | |
HN2010002408A (es) | Sal de difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-((1-(n-metilcarbamoilmetil)piperidin-4-il)oxi)quinazolina | |
CO6341474A2 (es) | Formas solidas de (1r,2s,3r)-1-(2-isoxazol-3-il)-1h-imidazol-4-il) butano-1,2,3,4-tetraol y metodos para su uso | |
AR061299A1 (es) | Sales de succionato de 6-metoxi -8- [4- (1-(5- fluor) -quinolin -8-il-piperidin-4-il) -piperazin-1-il] -quinolina y formas cristalinas de las mismas | |
UY32042A (es) | Compuestos de 2-aminopirimidina como potentes inhibidores de hsp-90 | |
ES2403130R1 (es) | Forma polimorfica de clorhidrato de fexofenadina, compuestos intermedios y procedimiento para su preparacion | |
BRPI0908509A2 (pt) | Formas de sal de um derivado de 6-flúor-1, 2-di-hidro-2-oxo-3h-indol-3-ilideno, processo para a produção das mesmas e composições farmacêuticas contendo as mesmas | |
CY1120307T1 (el) | Καινοφανεις ενωσεις επιλεκτικων ανταγωνιστων του υποδοχεα νκ-3, φαρμακευτικες συνθεσεις και μεθοδοι χρησης σε διαμεσολαβουμενες απο υποδοχεις νκ-3 διαταραχες |