ECSP10010397A - Preparacion y separacion enantiomerica de 7-(3- piridinilo)-1,7-diazaspiro[4.4] nonano y formas novedosas de sal de la mezcla racemica y enantiomeros - Google Patents

Preparacion y separacion enantiomerica de 7-(3- piridinilo)-1,7-diazaspiro[4.4] nonano y formas novedosas de sal de la mezcla racemica y enantiomeros

Info

Publication number
ECSP10010397A
ECSP10010397A EC2010010397A ECSP10010397A ECSP10010397A EC SP10010397 A ECSP10010397 A EC SP10010397A EC 2010010397 A EC2010010397 A EC 2010010397A EC SP10010397 A ECSP10010397 A EC SP10010397A EC SP10010397 A ECSP10010397 A EC SP10010397A
Authority
EC
Ecuador
Prior art keywords
diazaspiro
pyridinyl
nonano
salts
preparation
Prior art date
Application number
EC2010010397A
Other languages
English (en)
Inventor
Gary Maurice Dull
Scott R Breining
Gregory J Gatto
John Genus
Julio A Munoz
Inigo Pfeiffer
Jacob Mathew
Jessica Beaver
Steve M Toler
Wamsley James
Xie Jianxun
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of ECSP10010397A publication Critical patent/ECSP10010397A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Una síntesis novedosa escalable para la preparación de 7-(3- piridinilo)- 1,7- diazaspiro[4.4)nonano ha sido desarrollado, y sales 7-(3- piridinilo)-1,7-diazaspiro[4.4]nonano han sido formadas con ácido succínico y ácido oxálico. Adicionalmente, 7-(3-piridinilo)-1,7- diazaspiro[4.4)nonano ha sido separado en sus estereoisómeros por medio de resoluciones con ácidos di-p-toluoyltartaric L y D, dando (R)- y (S)-7-(3- piridinilo)-1,7- diazaspiro[4.4)nonano de enantiómeros de alta pureza. Numerosas sales solidas de os resultantes (R)- y (S)-7 -(3-piridinilo)-1,7-diazaspiro[4.4}nonano han sido preparados. Métodos para la preparación de sales racémicas y enantioméricas, composiciones farmacéuticas que componen dichas sales, y usos de las mismas son revelados. Las sales pueden ser suministradas a pacientes susceptibles de sufrir o sufriendo de condiciones y trastornos, como trastornos del sistema nervioso central, para tratar y/o prevenir dichos trastornos.
EC2010010397A 2008-01-15 2010-08-11 Preparacion y separacion enantiomerica de 7-(3- piridinilo)-1,7-diazaspiro[4.4] nonano y formas novedosas de sal de la mezcla racemica y enantiomeros ECSP10010397A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2119708P 2008-01-15 2008-01-15

Publications (1)

Publication Number Publication Date
ECSP10010397A true ECSP10010397A (es) 2010-09-30

Family

ID=40885603

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010397A ECSP10010397A (es) 2008-01-15 2010-08-11 Preparacion y separacion enantiomerica de 7-(3- piridinilo)-1,7-diazaspiro[4.4] nonano y formas novedosas de sal de la mezcla racemica y enantiomeros

Country Status (15)

Country Link
US (1) US20110118239A1 (es)
EP (1) EP2242364A4 (es)
JP (1) JP2011509933A (es)
KR (1) KR20100118113A (es)
CN (1) CN101951773A (es)
AU (1) AU2009205720A1 (es)
BR (1) BRPI0907222A2 (es)
CA (1) CA2712141A1 (es)
CO (1) CO6280577A2 (es)
EC (1) ECSP10010397A (es)
IL (1) IL206867A0 (es)
MX (1) MX2010007742A (es)
RU (1) RU2010133976A (es)
WO (1) WO2009091561A1 (es)
ZA (1) ZA201005284B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610146A (zh) * 2015-01-23 2015-05-13 常州大学 一种3-氮杂二环[5,1,0]-7-醛及合成方法
CN104628677A (zh) * 2015-03-16 2015-05-20 浙江大学 一种沃替西汀有机酸盐晶型及其制备方法
KR20170119447A (ko) * 2016-04-19 2017-10-27 주식회사 아미노로직스 Dl-4,4'-바이페닐알라닌 알킬에스터로부터 d-4,4'-바이페닐알라닌 알킬에스터 또는 l-4,4'-바이페닐알라닌 알킬에스터를 제조하는 방법
CN106008316B (zh) * 2016-06-17 2018-04-27 成都百事兴科技实业有限公司 一种合成雷迪帕韦手性中间体的方法
US20190124313A1 (en) 2017-10-19 2019-04-25 Intel Corporation Three dimensional glasses free light field display using eye location
CN112739686A (zh) * 2018-09-28 2021-04-30 赛特瑞恩股份有限公司 用于制备(-)-西苯唑啉琥珀酸盐的新方法
WO2020067683A1 (en) * 2018-09-28 2020-04-02 Celltrion Inc. Novel process for the preparation of (+)-cibenzoline succinate

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852041A (en) * 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5604231A (en) * 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5597919A (en) * 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US20020056084A1 (en) * 2000-03-15 2002-05-09 Harris Glen Mclean Active media content access system
GB0030171D0 (en) * 2000-12-11 2001-01-24 Cipla Ltd Process for preparing isomers of salbutamol
AU2003245753B2 (en) * 2002-07-05 2009-12-24 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
GB2403003B (en) * 2003-06-19 2006-06-07 Dek Int Gmbh Inspection system for and method of inspecting deposits printed on workpieces
BRPI0514509A (pt) * 2004-08-20 2008-06-10 Targacept Inc uso de composto n-aril diazaespiracìclicos no tratamento de dependência
US7459469B2 (en) * 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds

Also Published As

Publication number Publication date
CN101951773A (zh) 2011-01-19
JP2011509933A (ja) 2011-03-31
WO2009091561A1 (en) 2009-07-23
RU2010133976A (ru) 2012-02-27
EP2242364A1 (en) 2010-10-27
AU2009205720A1 (en) 2009-07-23
ZA201005284B (en) 2011-03-30
CA2712141A1 (en) 2009-07-23
CO6280577A2 (es) 2011-05-20
EP2242364A4 (en) 2011-09-21
KR20100118113A (ko) 2010-11-04
IL206867A0 (en) 2010-12-30
MX2010007742A (es) 2010-08-06
BRPI0907222A2 (pt) 2015-07-14
US20110118239A1 (en) 2011-05-19

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