ECSP088517A - Procedimiento para la preparacion del inhibidor del ciclo celular-779 cristalino y purificado - Google Patents
Procedimiento para la preparacion del inhibidor del ciclo celular-779 cristalino y purificadoInfo
- Publication number
- ECSP088517A ECSP088517A EC2008008517A ECSP088517A ECSP088517A EC SP088517 A ECSP088517 A EC SP088517A EC 2008008517 A EC2008008517 A EC 2008008517A EC SP088517 A ECSP088517 A EC SP088517A EC SP088517 A ECSP088517 A EC SP088517A
- Authority
- EC
- Ecuador
- Prior art keywords
- crystal
- procedure
- preparation
- cycle inhibitor
- purified cellular
- Prior art date
Links
- 230000001413 cellular effect Effects 0.000 title 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 abstract 1
- 229960000235 temsirolimus Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona CCI-779 cristalino purificado y procedimientos para preparar el mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74800605P | 2005-12-07 | 2005-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088517A true ECSP088517A (es) | 2008-07-30 |
Family
ID=37891446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008517A ECSP088517A (es) | 2005-12-07 | 2008-06-09 | Procedimiento para la preparacion del inhibidor del ciclo celular-779 cristalino y purificado |
Country Status (18)
Country | Link |
---|---|
US (1) | US7553843B2 (es) |
EP (1) | EP1957500A1 (es) |
JP (1) | JP2009518413A (es) |
KR (1) | KR20080077618A (es) |
CN (1) | CN101321769A (es) |
AR (1) | AR058282A1 (es) |
AU (1) | AU2006322029A1 (es) |
BR (1) | BRPI0619493A2 (es) |
CA (1) | CA2630784A1 (es) |
CR (1) | CR9988A (es) |
EC (1) | ECSP088517A (es) |
GT (1) | GT200800089A (es) |
IL (1) | IL191546A0 (es) |
NO (1) | NO20082379L (es) |
PE (1) | PE20071041A1 (es) |
RU (1) | RU2008121240A (es) |
TW (1) | TW200732342A (es) |
WO (1) | WO2007067565A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8754207B2 (en) | 2009-09-25 | 2014-06-17 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
CN109020995A (zh) * | 2017-06-12 | 2018-12-18 | 鲁南制药集团股份有限公司 | 一种替西罗莫司的晶型物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5358909A (en) * | 1991-02-27 | 1994-10-25 | Nippon Steel Corporation | Method of manufacturing field-emitter |
US5358908A (en) * | 1992-02-14 | 1994-10-25 | Micron Technology, Inc. | Method of creating sharp points and other features on the surface of a semiconductor substrate |
US5385909A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
US5385908A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
DE60136200D1 (de) | 2000-09-19 | 2008-11-27 | Wyeth Corp | Wasserlösliche rapamycin-ester |
FR2826961B1 (fr) * | 2001-07-06 | 2005-09-30 | Atofina | Procede de preparation d'anhydride (meth) acrylique |
WO2005010010A1 (en) * | 2003-07-16 | 2005-02-03 | Wyeth | Cci-779 isomer c |
KR20060057605A (ko) * | 2003-08-07 | 2006-05-26 | 와이어쓰 | Cci-779의 위치선택적 합성 방법 |
JP2007504226A (ja) * | 2003-09-03 | 2007-03-01 | ワイス | 非晶質状のラパマイシンの3−ヒドロキシ−2−(ヒドロキシメチル)−2−メチルプロピオン酸との42−エステル、およびそれを含むその医薬組成物 |
SG152234A1 (en) * | 2004-04-14 | 2009-05-29 | Wyeth Corp | Regiospecific synthesis of rapamycin 42-ester derivatives |
ATE410431T1 (de) * | 2004-04-14 | 2008-10-15 | Wyeth Corp | Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper |
AU2005292647A1 (en) * | 2004-08-10 | 2006-04-13 | Wyeth | CCI-779 derivatives and methods of making same |
US7273874B2 (en) * | 2004-12-20 | 2007-09-25 | Wyeth | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders |
DK1828202T3 (da) * | 2004-12-20 | 2012-05-07 | Wyeth Llc | Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser |
KR20070107030A (ko) * | 2005-02-09 | 2007-11-06 | 와이어쓰 | Cci-779 다형체 및 그의 용도 |
AU2006218916A1 (en) * | 2005-03-02 | 2006-09-08 | Wyeth | Recovery of CCI-779 from mother liquors |
US7241771B2 (en) * | 2005-03-07 | 2007-07-10 | Wyeth | Oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin |
-
2006
- 2006-12-06 RU RU2008121240/04A patent/RU2008121240A/ru not_active Application Discontinuation
- 2006-12-06 CN CNA2006800458140A patent/CN101321769A/zh not_active Withdrawn
- 2006-12-06 TW TW095145388A patent/TW200732342A/zh unknown
- 2006-12-06 AR ARP060105388A patent/AR058282A1/es unknown
- 2006-12-06 BR BRPI0619493A patent/BRPI0619493A2/pt not_active IP Right Cessation
- 2006-12-06 CA CA002630784A patent/CA2630784A1/en not_active Abandoned
- 2006-12-06 JP JP2008544450A patent/JP2009518413A/ja active Pending
- 2006-12-06 PE PE2006001556A patent/PE20071041A1/es not_active Application Discontinuation
- 2006-12-06 KR KR1020087013678A patent/KR20080077618A/ko not_active Application Discontinuation
- 2006-12-06 EP EP06839039A patent/EP1957500A1/en not_active Withdrawn
- 2006-12-06 AU AU2006322029A patent/AU2006322029A1/en not_active Abandoned
- 2006-12-06 WO PCT/US2006/046444 patent/WO2007067565A1/en active Application Filing
- 2006-12-06 US US11/634,774 patent/US7553843B2/en not_active Expired - Fee Related
-
2008
- 2008-05-19 IL IL191546A patent/IL191546A0/en unknown
- 2008-05-19 CR CR9988A patent/CR9988A/es not_active Application Discontinuation
- 2008-05-26 NO NO20082379A patent/NO20082379L/no not_active Application Discontinuation
- 2008-06-05 GT GT200800089A patent/GT200800089A/es unknown
- 2008-06-09 EC EC2008008517A patent/ECSP088517A/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW200732342A (en) | 2007-09-01 |
RU2008121240A (ru) | 2010-01-20 |
AR058282A1 (es) | 2008-01-30 |
BRPI0619493A2 (pt) | 2016-09-06 |
CN101321769A (zh) | 2008-12-10 |
KR20080077618A (ko) | 2008-08-25 |
IL191546A0 (en) | 2008-12-29 |
WO2007067565A1 (en) | 2007-06-14 |
US20070129395A1 (en) | 2007-06-07 |
PE20071041A1 (es) | 2007-12-07 |
AU2006322029A1 (en) | 2007-06-14 |
JP2009518413A (ja) | 2009-05-07 |
CR9988A (es) | 2008-07-29 |
NO20082379L (no) | 2008-09-04 |
US7553843B2 (en) | 2009-06-30 |
GT200800089A (es) | 2008-12-04 |
CA2630784A1 (en) | 2007-06-14 |
EP1957500A1 (en) | 2008-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GT200600264A (es) | Modificaciones cristalinas de piraclostrobina | |
ECSP078055A (es) | Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas | |
UY32859A (es) | Compuestos y composiciones como inhibidores de cinasa de proteina | |
CO6640285A2 (es) | 5-alquinil-pirimidinas | |
TW200716512A (en) | Processes for preparing cinacalcet hydrochloride crystal form I | |
ECSP077268A (es) | Polimorfo ii de rapamicina y los usos de los mismos | |
DOP2013000036A (es) | Derivados de ciclobutano como inhibidores de jak | |
ATE528989T1 (de) | Kristalline feste rasagilin-base | |
CR20180142A (es) | ANTICUERPOS ANTI-FAP Y MÉTODOS DE USO(Divisional Exp: 2013-0038) | |
CR11861A (es) | Compuestos organicos | |
HN2006011218A (es) | Composiciones de tigeciclina y métodos de preparación | |
CR11818A (es) | Derivados de triazol utiles para el tratamiento de enfermedades | |
ECSP088905A (es) | Nuevos compuestos | |
AR061311A1 (es) | Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo | |
CL2009001686A1 (es) | Procedimiento de preparacion de agomelatina; y los compuestos intermediarios considerados. | |
ECSP11010786A (es) | 5-alquinil-pirimidinas | |
AR058253A1 (es) | Procedimiento para la preparacion de ferri-succinilcaseina | |
UY29434A1 (es) | Derivados de tetrahidronaftalina, procedimientos para su preparación y su uso como inhibidores de la inflamacinn | |
SV2005002015A (es) | Procesos para la preparacion de haluros de aril- y heteroaril-alquilsulfonilo - ref. wyth0008-504 (am101302) | |
UY31700A (es) | Tiazolil-dihidro-indazoles | |
CR9257A (es) | Polimorfo cci-779 y uso del mismo | |
CR11368A (es) | Forma cristalina 1 de 2- ( (r)-2-metilpirrolidin-2-il) -1h-benzimidazol-4-carboxamida | |
ECSP11011454A (es) | 5-alquinil-piridinas | |
NI200700175A (es) | Procesos para la preparación de alcoholes de aminoetoxibencilo | |
ECSP088517A (es) | Procedimiento para la preparacion del inhibidor del ciclo celular-779 cristalino y purificado |