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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La presente invención proporciona compuestos de la fórmula (I) en la que X, Y, R1, R2, R3, R4, R5 y R6 son como se definió anteriormente en la presente memoria. Los compuestos de la presente invención son moduladores, especialmente antagonistas, de la actividad de los receptores CCR5 de quimioquinas. Los moduladores del receptor CCR5 pueden ser útiles para el tratamiento de diversas enfermedades inflamatorias y situaciones con inflamaciones, y para el tratamiento de la infección por el HIV-1 y retrovirus genéticamente relacionados.The present invention provides compounds of the formula (I) in which X, Y, R1, R2, R3, R4, R5 and R6 are as defined hereinbefore. The compounds of the present invention are modulators, especially antagonists, of the activity of CCR5 chemokine receptors. CCR5 receptor modulators can be useful for the treatment of various inflammatory diseases and situations with inflammations, and for the treatment of HIV-1 infection and genetically related retroviruses.
ECSP0453442004-10-082004-10-08
USEFUL TROPANO DERIVATIVES IN THERAPY
ECSP045344A
(en)
Normal;heading 1;heading 2;IMIDAZOPYRIDINE SUBSTITUTED TROPANE DERIVATIVES WITH CCR5 RECEPTOR ANTAGONIST ACTIVITY FOR THE TREATMENT OF HIV AND INFLAMMATION