DOP2004001002A - DERIVATIVES OF 2-METHYL-4,5,6,7-TETRAHIDRO-1H-IMIDAZO [4,5, C] -PIRIDIN-1-IL-8-AZABICLO- [3.2.1] -OCTO-8-IL] - 1- (3-FLUOROPHENYL) PROPIL WITH ANTIGONIST ACTIVITY OF CCR5 RECEIVER - Google Patents

DERIVATIVES OF 2-METHYL-4,5,6,7-TETRAHIDRO-1H-IMIDAZO [4,5, C] -PIRIDIN-1-IL-8-AZABICLO- [3.2.1] -OCTO-8-IL] - 1- (3-FLUOROPHENYL) PROPIL WITH ANTIGONIST ACTIVITY OF CCR5 RECEIVER

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Publication number
DOP2004001002A
DOP2004001002A DO2004001002A DO2004001002A DOP2004001002A DO P2004001002 A DOP2004001002 A DO P2004001002A DO 2004001002 A DO2004001002 A DO 2004001002A DO 2004001002 A DO2004001002 A DO 2004001002A DO P2004001002 A DOP2004001002 A DO P2004001002A
Authority
DO
Dominican Republic
Prior art keywords
activity
azabiclo
antigonist
tetrahidro
propil
Prior art date
Application number
DO2004001002A
Other languages
Spanish (es)
Inventor
Paul Anthony Stupple
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to DO2004001002A priority Critical patent/DOP2004001002A/en
Publication of DOP2004001002A publication Critical patent/DOP2004001002A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion proporciona compuestos de formula (I) en la que R1 y R2 son como se definen anteriormente en la presente memoria. Los compuestos de la presente invencion son moduladores, especialmente antagonistas, de la actividad de receptores CCR5 de quimioquinas. Los moduladores de receptor CCR5 pueden ser utiles en el tratamiento de diversas enfermedades y afecciones inflamatorias y en el tratamiento de infección por VIH y retrovirus geneticamente relacionados.The present invention provides compounds of formula (I) in which R1 and R2 are as defined hereinbefore. The compounds of the present invention are modulators, especially antagonists, of the activity of CCR5 chemokine receptors. CCR5 receptor modulators can be useful in the treatment of various inflammatory diseases and conditions and in the treatment of HIV infection and genetically related retroviruses.

DO2004001002A 2004-10-01 2004-10-01 DERIVATIVES OF 2-METHYL-4,5,6,7-TETRAHIDRO-1H-IMIDAZO [4,5, C] -PIRIDIN-1-IL-8-AZABICLO- [3.2.1] -OCTO-8-IL] - 1- (3-FLUOROPHENYL) PROPIL WITH ANTIGONIST ACTIVITY OF CCR5 RECEIVER DOP2004001002A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DO2004001002A DOP2004001002A (en) 2004-10-01 2004-10-01 DERIVATIVES OF 2-METHYL-4,5,6,7-TETRAHIDRO-1H-IMIDAZO [4,5, C] -PIRIDIN-1-IL-8-AZABICLO- [3.2.1] -OCTO-8-IL] - 1- (3-FLUOROPHENYL) PROPIL WITH ANTIGONIST ACTIVITY OF CCR5 RECEIVER

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DO2004001002A DOP2004001002A (en) 2004-10-01 2004-10-01 DERIVATIVES OF 2-METHYL-4,5,6,7-TETRAHIDRO-1H-IMIDAZO [4,5, C] -PIRIDIN-1-IL-8-AZABICLO- [3.2.1] -OCTO-8-IL] - 1- (3-FLUOROPHENYL) PROPIL WITH ANTIGONIST ACTIVITY OF CCR5 RECEIVER

Publications (1)

Publication Number Publication Date
DOP2004001002A true DOP2004001002A (en) 2005-04-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
DO2004001002A DOP2004001002A (en) 2004-10-01 2004-10-01 DERIVATIVES OF 2-METHYL-4,5,6,7-TETRAHIDRO-1H-IMIDAZO [4,5, C] -PIRIDIN-1-IL-8-AZABICLO- [3.2.1] -OCTO-8-IL] - 1- (3-FLUOROPHENYL) PROPIL WITH ANTIGONIST ACTIVITY OF CCR5 RECEIVER

Country Status (1)

Country Link
DO (1) DOP2004001002A (en)

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