ECSP045110A - Composiciones de la preparación que contiene un compuesto fisiologicamente activo de acidos inestables y procesos para su producción - Google Patents

Composiciones de la preparación que contiene un compuesto fisiologicamente activo de acidos inestables y procesos para su producción

Info

Publication number
ECSP045110A
ECSP045110A EC2004005110A ECSP045110A ECSP045110A EC SP045110 A ECSP045110 A EC SP045110A EC 2004005110 A EC2004005110 A EC 2004005110A EC SP045110 A ECSP045110 A EC SP045110A EC SP045110 A ECSP045110 A EC SP045110A
Authority
EC
Ecuador
Prior art keywords
composition
preparation
active compound
production
compositions
Prior art date
Application number
EC2004005110A
Other languages
English (en)
Inventor
Shigeru Aoki
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ECSP045110A publication Critical patent/ECSP045110A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se tiene la intención de divulgar la composición de la preparación la cual permita la producción conveniente de la composición de la preparación de liberación sostenida que contiene un compuesto activo de ácidos fisiológicamente inestables y tiene las propiedades de liberación sostenida deseada. En especial, la composición de la preparación que comprende un núcleo que contiene un compuesto activo de ácidos fisiológicamente inestables y una capa con la cual el núcleo es revestido y el cual contiene una mezcla de un polímero insoluble en agua y un polímero entérico. La composición de la preparación según la actual invención permite mantener una concentración eficaz en la sangre del compuesto fisiológico activo durante mucho tiempo, mejorando de tal modo su efecto terapéutico. Además, la composición según la actual invención se mantiene estable durante almacenajes prolongados.
EC2004005110A 2001-11-21 2004-05-17 Composiciones de la preparación que contiene un compuesto fisiologicamente activo de acidos inestables y procesos para su producción ECSP045110A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001356018 2001-11-21

Publications (1)

Publication Number Publication Date
ECSP045110A true ECSP045110A (es) 2004-08-27

Family

ID=19167613

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005110A ECSP045110A (es) 2001-11-21 2004-05-17 Composiciones de la preparación que contiene un compuesto fisiologicamente activo de acidos inestables y procesos para su producción

Country Status (25)

Country Link
EP (1) EP1454634A4 (es)
JP (1) JP4540092B2 (es)
KR (1) KR20050044545A (es)
CN (2) CN101982199A (es)
AP (1) AP1919A (es)
AU (1) AU2002366029B2 (es)
BR (1) BR0214372A (es)
CA (1) CA2466726C (es)
CO (1) CO5580800A2 (es)
CR (1) CR7351A (es)
EC (1) ECSP045110A (es)
HU (1) HUP0402323A3 (es)
IL (2) IL161983A0 (es)
IS (1) IS7266A (es)
MA (1) MA26346A1 (es)
MX (1) MXPA04004775A (es)
NO (1) NO20042563L (es)
NZ (1) NZ532907A (es)
RO (1) RO122395B1 (es)
RU (1) RU2311906C2 (es)
SI (1) SI21447A (es)
TW (1) TWI302461B (es)
UA (1) UA76256C2 (es)
WO (1) WO2003043661A1 (es)
ZA (1) ZA200403551B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
NZ549838A (en) * 2004-03-26 2010-04-30 Eisai R&D Man Co Ltd Coated controlled-release preparation containing a gastric acid secretion inhibitor
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
WO2006047493A2 (en) 2004-10-21 2006-05-04 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
EP1830886B1 (en) 2004-12-27 2016-04-13 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
WO2006123364A2 (en) * 2005-03-14 2006-11-23 Sun Pharmaceutical Industries Limited Oral drug delivery system providing a coating comprising both a cellulose and a methacrylic acid derivative
WO2006111853A2 (en) * 2005-04-18 2006-10-26 Aurobindo Pharma Limited Stable solid dosage forms of acid labile drug
US9161918B2 (en) * 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US20100105738A1 (en) * 2006-10-06 2010-04-29 Mitsuru Mizuno Extended release formulations of a proton pump inhibitor
RU2414889C2 (ru) * 2007-11-16 2011-03-27 Общество С Ограниченной Ответственностью "Технология Лекарств" Фармацевтическая композиция для лечения язвы желудка и двенадцатиперстной кишки в форме твердых желатиновых капсул, содержащая рабепразол или его производные, и способ ее получения
CA2704826A1 (en) * 2007-11-27 2009-06-04 Ohara Pharmaceutical Co., Ltd. Method for producing granulated preparation
CN101822671A (zh) * 2009-03-06 2010-09-08 信谊药厂 雷贝拉唑组合物及其制备方法
CN102958515A (zh) 2009-12-02 2013-03-06 阿普塔利斯制药有限公司 非索非那定微胶囊及含有非索非那定微胶囊的组合物
NZ605562A (en) * 2010-07-09 2013-11-29 Teijin Pharma Ltd Deuterated benzylbenzene derivatives and methods of use
JP2018184360A (ja) * 2017-04-25 2018-11-22 ニプロ株式会社 経口投与用の腸溶性徐放性製剤
KR102227486B1 (ko) * 2017-06-30 2021-03-12 롯데정밀화학 주식회사 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
JPS5944311A (ja) * 1982-09-07 1984-03-12 Santen Pharmaceut Co Ltd 徐放性顆粒およびその製造法
ES2077023T3 (es) * 1989-03-10 1995-11-16 Yamanouchi Pharma Co Ltd Material de recubrimiento que controla la liberacion de un medicamento para formulaciones de actividad prolongada.
GB8926639D0 (en) * 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
EP0447168A3 (en) * 1990-03-16 1993-01-07 Yamanouchi Pharmaceutical Co. Ltd. Long acting granular pharmaceutical composition
JPH0826977A (ja) * 1994-07-19 1996-01-30 Tanabe Seiyaku Co Ltd 溶出制御型経口製剤
JPH09323926A (ja) * 1996-03-15 1997-12-16 Nikken Chem Co Ltd バルプロ酸ナトリウムの徐放性錠剤
ES2137862B1 (es) * 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
US20020039597A1 (en) * 1998-04-20 2002-04-04 Koji Ukai Stabilized compositions containing benzimidazole-type compounds
EP1121103B1 (en) * 1998-05-18 2006-12-20 Takeda Pharmaceutical Company Limited Orally disintegrable tablets comprising a benzimidazole
JP2001055322A (ja) * 1999-08-18 2001-02-27 Tanabe Seiyaku Co Ltd パルス放出型製剤
RU2259828C2 (ru) * 1999-10-20 2005-09-10 Эйсай Ко., Лтд. Способы стабилизации соединений на основе бензимидазола
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems

Also Published As

Publication number Publication date
AP1919A (en) 2008-11-13
RU2004118495A (ru) 2005-03-20
CO5580800A2 (es) 2005-11-30
HUP0402323A2 (hu) 2005-02-28
IL161983A (en) 2009-11-18
KR20050044545A (ko) 2005-05-12
JP4540092B2 (ja) 2010-09-08
NO20042563L (no) 2004-06-18
EP1454634A4 (en) 2007-05-30
BR0214372A (pt) 2004-10-26
AP2004003045A0 (en) 2004-06-30
IS7266A (is) 2004-05-14
IL161983A0 (en) 2005-11-20
CN1589156A (zh) 2005-03-02
WO2003043661A1 (fr) 2003-05-30
CA2466726A1 (en) 2003-05-30
ZA200403551B (en) 2005-07-07
RU2311906C2 (ru) 2007-12-10
TWI302461B (en) 2008-11-01
MA26346A1 (fr) 2004-10-01
MXPA04004775A (es) 2005-02-17
RO122395B1 (ro) 2009-05-29
HUP0402323A3 (en) 2008-04-28
EP1454634A1 (en) 2004-09-08
AU2002366029A1 (en) 2003-06-10
AU2002366029B2 (en) 2008-01-31
TW200300353A (en) 2003-06-01
UA76256C2 (en) 2006-07-17
CN101982199A (zh) 2011-03-02
CR7351A (es) 2005-05-12
JPWO2003043661A1 (ja) 2005-03-10
SI21447A (sl) 2004-10-31
CA2466726C (en) 2011-02-22
NZ532907A (en) 2007-05-31

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