ECSP024267A - Imidazotriazinonas sustituidas por 2-fenilo - Google Patents

Imidazotriazinonas sustituidas por 2-fenilo

Info

Publication number
ECSP024267A
ECSP024267A EC2002004267A ECSP024267A ECSP024267A EC SP024267 A ECSP024267 A EC SP024267A EC 2002004267 A EC2002004267 A EC 2002004267A EC SP024267 A ECSP024267 A EC SP024267A EC SP024267 A ECSP024267 A EC SP024267A
Authority
EC
Ecuador
Prior art keywords
phenyl
imidazotriazinones
replaced
treatment
diseases
Prior art date
Application number
EC2002004267A
Other languages
English (en)
Inventor
Ulrich Niewoehner
Matthias Nauck
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ECSP024267A publication Critical patent/ECSP024267A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Las imidazotriazinonas 2-fenil-sustituidas que tienen radicales de alquilo lineales cortas, en la posición 9 se preparan de las correspondientes imidazotriazinonas 2-fenil por clorosulfonación y la reacción subsecuente con las aminas. Los compuestos que inhiben las fosfodiesterasas que metabolizan el GMPc y son apropiadas para utilizarse como compuestos activos en los medicamentos, para el tratamiento de enfermedades cardiovasculares y cerebrovasculares y/o enfermedades del sistema urogenital, en particular el tratamiento de la disfunción eréctil
EC2002004267A 1997-11-12 2002-05-28 Imidazotriazinonas sustituidas por 2-fenilo ECSP024267A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19750085A DE19750085A1 (de) 1997-11-12 1997-11-12 2-Phenyl-substituierte Imidazotriazinone

Publications (1)

Publication Number Publication Date
ECSP024267A true ECSP024267A (es) 2002-06-26

Family

ID=7848473

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004267A ECSP024267A (es) 1997-11-12 2002-05-28 Imidazotriazinonas sustituidas por 2-fenilo

Country Status (6)

Country Link
DE (1) DE19750085A1 (es)
EC (1) ECSP024267A (es)
GT (1) GT199800183A (es)
RU (1) RU2260593C2 (es)
SV (1) SV1998000135A (es)
ZA (1) ZA9810297B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
PL2619208T3 (pl) * 2010-09-20 2017-03-31 Ironwood Pharmaceuticals, Inc. Związki imidazotriazynonu
CN102134242B (zh) * 2011-01-21 2013-08-28 浙江大德药业集团有限公司 一种用于治疗阳痿的快速长效的化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
ZA9810297B (en) 1999-05-20
DE19750085A1 (de) 1999-05-20
GT199800183A (es) 2000-05-04
RU2260593C2 (ru) 2005-09-20
SV1998000135A (es) 1999-03-09

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