ECSP024267A - IMIDAZOTRIAZINONES REPLACED BY 2-PHENYL - Google Patents

IMIDAZOTRIAZINONES REPLACED BY 2-PHENYL

Info

Publication number
ECSP024267A
ECSP024267A EC2002004267A ECSP024267A ECSP024267A EC SP024267 A ECSP024267 A EC SP024267A EC 2002004267 A EC2002004267 A EC 2002004267A EC SP024267 A ECSP024267 A EC SP024267A EC SP024267 A ECSP024267 A EC SP024267A
Authority
EC
Ecuador
Prior art keywords
phenyl
imidazotriazinones
replaced
treatment
diseases
Prior art date
Application number
EC2002004267A
Other languages
Spanish (es)
Inventor
Ulrich Niewoehner
Matthias Nauck
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ECSP024267A publication Critical patent/ECSP024267A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Las imidazotriazinonas 2-fenil-sustituidas que tienen radicales de alquilo lineales cortas, en la posición 9 se preparan de las correspondientes imidazotriazinonas 2-fenil por clorosulfonación y la reacción subsecuente con las aminas. Los compuestos que inhiben las fosfodiesterasas que metabolizan el GMPc y son apropiadas para utilizarse como compuestos activos en los medicamentos, para el tratamiento de enfermedades cardiovasculares y cerebrovasculares y/o enfermedades del sistema urogenital, en particular el tratamiento de la disfunción eréctil2-Phenyl-substituted imidazotriazinones having short linear alkyl radicals, at position 9, are prepared from the corresponding 2-phenyl imidazotriazinones by chlorosulfonation and subsequent reaction with the amines. Compounds that inhibit phosphodiesterases that metabolize cGMP and are suitable for use as active compounds in drugs, for the treatment of cardiovascular and cerebrovascular diseases and / or diseases of the urogenital system, in particular the treatment of erectile dysfunction

EC2002004267A 1997-11-12 2002-05-28 IMIDAZOTRIAZINONES REPLACED BY 2-PHENYL ECSP024267A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19750085A DE19750085A1 (en) 1997-11-12 1997-11-12 New 2-phenyl-imidazotriazinone derivatives used for treating cardiovascular, cerebrovascular and urogenital disorders

Publications (1)

Publication Number Publication Date
ECSP024267A true ECSP024267A (en) 2002-06-26

Family

ID=7848473

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004267A ECSP024267A (en) 1997-11-12 2002-05-28 IMIDAZOTRIAZINONES REPLACED BY 2-PHENYL

Country Status (6)

Country Link
DE (1) DE19750085A1 (en)
EC (1) ECSP024267A (en)
GT (1) GT199800183A (en)
RU (1) RU2260593C2 (en)
SV (1) SV1998000135A (en)
ZA (1) ZA9810297B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
WO2012040230A1 (en) * 2010-09-20 2012-03-29 Envivo Pharmaceuticals, Inc. Imidazotriazinone compounds
CN102134242B (en) * 2011-01-21 2013-08-28 浙江大德药业集团有限公司 Novel compounds for quickly treating impotence with long-lasting action

Also Published As

Publication number Publication date
DE19750085A1 (en) 1999-05-20
GT199800183A (en) 2000-05-04
SV1998000135A (en) 1999-03-09
RU2260593C2 (en) 2005-09-20
ZA9810297B (en) 1999-05-20

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