PA8457001A1 - DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-I-ILMETIL) -1H-INDOL - Google Patents

DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-I-ILMETIL) -1H-INDOL

Info

Publication number
PA8457001A1
PA8457001A1 PA19988457001A PA8457001A PA8457001A1 PA 8457001 A1 PA8457001 A1 PA 8457001A1 PA 19988457001 A PA19988457001 A PA 19988457001A PA 8457001 A PA8457001 A PA 8457001A PA 8457001 A1 PA8457001 A1 PA 8457001A1
Authority
PA
Panama
Prior art keywords
ilmetil
heteroaril
aril
piperazin
indol
Prior art date
Application number
PA19988457001A
Other languages
Spanish (es)
Inventor
Anton Franz Josef Fliri
Mark Jerome Majchrzak
Patricia Ann Seymour
Stevin Howard Zorn
Hans Rollema
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8457001A1 publication Critical patent/PA8457001A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LA PRESENTE INVENCION SE REFIERE A LOS DERIVADOS 2-(4-ARIL O HETEROARIL-PIPERAZIN-1-ILMETIL)-1H-INDOL QUE POSEEN ACTIVIDAD DOPAMINERGICA CENTRAL. TALES COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL(SNC). ESTA INVENCION TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE USO DE DICHOS COMPUESTOS EN EL TRATAMIENTO DE LOS TRASTORNOS ANTERIORES EN MAMIFEROS, ESPECIALMENTE EN HUMANOS Y LAS COMPOSICIONES FARMACEUTICAS UTILES DE LAS MISMAS.THE PRESENT INVENTION REFERS TO DERIVATIVES 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) -1H-INDOL THAT HAVE CENTRAL DOPAMINERGIC ACTIVITY. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS. THIS INVENTION ALSO REFERS TO A PROCEDURE FOR THE USE OF SUCH COMPOUNDS IN THE TREATMENT OF PREVIOUS DISORDERS IN MAMMALS, ESPECIALLY IN HUMANS AND USEFUL PHARMACEUTICAL COMPOSITIONS OF THE SAME.

PA19988457001A 1997-08-15 1998-08-10 DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-I-ILMETIL) -1H-INDOL PA8457001A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5576497P 1997-08-15 1997-08-15

Publications (1)

Publication Number Publication Date
PA8457001A1 true PA8457001A1 (en) 2000-09-29

Family

ID=22000003

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988457001A PA8457001A1 (en) 1997-08-15 1998-08-10 DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-I-ILMETIL) -1H-INDOL

Country Status (30)

Country Link
EP (1) EP1003739A2 (en)
JP (1) JP2002536291A (en)
KR (1) KR20010022507A (en)
CN (1) CN1265660A (en)
AP (1) AP9801321A0 (en)
AR (1) AR017019A1 (en)
AU (1) AU8457298A (en)
BG (1) BG104069A (en)
BR (1) BR9811557A (en)
CA (1) CA2297486C (en)
CO (1) CO4960656A1 (en)
DZ (1) DZ2583A1 (en)
EA (1) EA200000023A1 (en)
HR (1) HRP980441A2 (en)
HU (1) HUP0003425A3 (en)
ID (1) ID23803A (en)
IL (1) IL133960A0 (en)
IS (1) IS5336A (en)
MA (1) MA24632A1 (en)
NO (1) NO20000722D0 (en)
OA (1) OA11286A (en)
PA (1) PA8457001A1 (en)
PE (1) PE106299A1 (en)
PL (1) PL338947A1 (en)
SK (1) SK1352000A3 (en)
TN (1) TNSN98151A1 (en)
TR (1) TR200000414T2 (en)
UY (1) UY25144A1 (en)
WO (1) WO1999009025A2 (en)
ZA (1) ZA987304B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2205179C2 (en) * 1997-10-27 2003-05-27 НьюроСёрч А/С Homopiperazine derivative and pharmaceutical composition
EP0953567A3 (en) 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
DK1464641T3 (en) 1999-12-30 2008-08-18 Lundbeck & Co As H 4-phenylpiperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine D4 antagonists
GB0017952D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of dyskinesia
EP1177792A3 (en) 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
WO2002072548A2 (en) * 2001-03-09 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds and their use as histamine h4 ligands.
RU2005106274A (en) 2002-09-06 2005-11-10 Янссен Фармацевтика, Н.В. (Be) HETEROCYCLIC COMPOUNDS
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
EP2253315A1 (en) 2004-03-30 2010-11-24 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
US7618980B2 (en) 2004-07-14 2009-11-17 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5HT ligands
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Fast Dissociting Dopamine 2 Receptor Antagonists
JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Fast Dissociating Dopamine 2 Receptor Antagonists
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Fast -Dissociating Dopamine 2 Receptor Antagonists
US8906921B2 (en) 2007-04-23 2014-12-09 Janssen Pharmaceutica Nv 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
ES2400710T3 (en) 2007-04-23 2013-04-11 Janssen Pharmaceutica, N.V. Tia (dia) zoles as fast dissociation dopamine 2 receptor antagonists
WO2010000456A1 (en) 2008-07-03 2010-01-07 Janssen Pharmaceutica Nv Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists
EA019048B1 (en) 2008-07-31 2013-12-30 Янссен Фармацевтика Нв Piperazin-1-yl-trifluoromethyl-substituted pyridines as fast dissociating dopamine 2 receptor antagonists
CN109843872B (en) * 2017-09-20 2022-08-30 杭州英创医药科技有限公司 Polycyclic compounds as IDO inhibitors and/or IDO-HDAC dual inhibitors
CA3171950A1 (en) * 2020-04-22 2021-10-28 David William Sheppard Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (en) * 1959-09-25 1900-01-01
WO1993001181A1 (en) * 1991-07-03 1993-01-21 The Upjohn Company Substituted indoles as anti-aids pharmaceuticals
JPH05255089A (en) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd Antiviral agent
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5576336A (en) * 1993-03-18 1996-11-19 Merck Sharp & Dohme Limited Indole derivatives as dopamine D4 antagonists
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
DE4414113A1 (en) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-indolylpiperidines
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives

Also Published As

Publication number Publication date
MA24632A1 (en) 1999-04-01
PL338947A1 (en) 2000-12-04
EA200000023A1 (en) 2000-08-28
ZA987304B (en) 2000-02-14
ID23803A (en) 2000-05-11
CA2297486A1 (en) 1999-02-25
NO20000722L (en) 2000-02-14
OA11286A (en) 2003-10-22
KR20010022507A (en) 2001-03-15
SK1352000A3 (en) 2000-08-14
NO20000722D0 (en) 2000-02-14
BG104069A (en) 2001-05-31
HUP0003425A3 (en) 2002-02-28
AP9801321A0 (en) 2000-02-14
WO1999009025A3 (en) 1999-04-15
EP1003739A2 (en) 2000-05-31
PE106299A1 (en) 1999-11-02
HRP980441A2 (en) 1999-04-30
IS5336A (en) 2000-01-11
AU8457298A (en) 1999-03-08
TR200000414T2 (en) 2000-08-21
JP2002536291A (en) 2002-10-29
CN1265660A (en) 2000-09-06
UY25144A1 (en) 2000-12-29
CA2297486C (en) 2005-05-03
AR017019A1 (en) 2001-08-22
TNSN98151A1 (en) 2005-03-15
IL133960A0 (en) 2001-04-30
DZ2583A1 (en) 2003-02-22
CO4960656A1 (en) 2000-09-25
WO1999009025A2 (en) 1999-02-25
HUP0003425A2 (en) 2001-10-28
BR9811557A (en) 2000-08-22

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