EA200000023A1 - DERIVATIVES 2 - (- 4-Aryl or Heteroaryl-Piperisin-1-Ilmethyl) -1H-Indole - Google Patents
DERIVATIVES 2 - (- 4-Aryl or Heteroaryl-Piperisin-1-Ilmethyl) -1H-IndoleInfo
- Publication number
- EA200000023A1 EA200000023A1 EA200000023A EA200000023A EA200000023A1 EA 200000023 A1 EA200000023 A1 EA 200000023A1 EA 200000023 A EA200000023 A EA 200000023A EA 200000023 A EA200000023 A EA 200000023A EA 200000023 A1 EA200000023 A1 EA 200000023A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- indole
- heteroaryl
- aryl
- derivatives
- piperisin
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 abstract 2
- 102100029815 D(4) dopamine receptor Human genes 0.000 abstract 1
- 101000865206 Homo sapiens D(4) dopamine receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Производные 2-(4-арил или гетероарил-пиперазин-1-илметил)-1H-индола формулы (I), где a, T, V, X, Y, Z, R, R, RR, RR, R, Rи Rтакие, как определено выше, их фармацевтически приемлемые соли и фармацевтические композиции, содержащие такие соединения или их соли, взаимодействующие с дофаминным рецептором D4.Отчет о международном поиске был опубликован 1999.04.15.Derivatives of 2- (4-aryl or heteroaryl-piperazin-1-ylmethyl) -1H-indole of formula (I), where a, T, V, X, Y, Z, R, R, RR, RR, R, R and R are as defined above, their pharmaceutically acceptable salts and pharmaceutical compositions containing such compounds or their salts interacting with the dopamine receptor D4. The international search report was published 1999.04.15.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5576497P | 1997-08-15 | 1997-08-15 | |
PCT/IB1998/001198 WO1999009025A2 (en) | 1997-08-15 | 1998-08-05 | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200000023A1 true EA200000023A1 (en) | 2000-08-28 |
Family
ID=22000003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000023A EA200000023A1 (en) | 1997-08-15 | 1998-08-05 | DERIVATIVES 2 - (- 4-Aryl or Heteroaryl-Piperisin-1-Ilmethyl) -1H-Indole |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1003739A2 (en) |
JP (1) | JP2002536291A (en) |
KR (1) | KR20010022507A (en) |
CN (1) | CN1265660A (en) |
AP (1) | AP9801321A0 (en) |
AR (1) | AR017019A1 (en) |
AU (1) | AU8457298A (en) |
BG (1) | BG104069A (en) |
BR (1) | BR9811557A (en) |
CA (1) | CA2297486C (en) |
CO (1) | CO4960656A1 (en) |
DZ (1) | DZ2583A1 (en) |
EA (1) | EA200000023A1 (en) |
HR (1) | HRP980441A2 (en) |
HU (1) | HUP0003425A3 (en) |
ID (1) | ID23803A (en) |
IL (1) | IL133960A0 (en) |
IS (1) | IS5336A (en) |
MA (1) | MA24632A1 (en) |
NO (1) | NO20000722L (en) |
OA (1) | OA11286A (en) |
PA (1) | PA8457001A1 (en) |
PE (1) | PE106299A1 (en) |
PL (1) | PL338947A1 (en) |
SK (1) | SK1352000A3 (en) |
TN (1) | TNSN98151A1 (en) |
TR (1) | TR200000414T2 (en) |
UY (1) | UY25144A1 (en) |
WO (1) | WO1999009025A2 (en) |
ZA (1) | ZA987304B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL203140B1 (en) * | 1997-10-27 | 2009-08-31 | Neurosearch As | Heteroaryl diazacycloalkanes an cholinergic legends of nicotinic acetylcholine receptors |
EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
AU783786B2 (en) * | 1999-12-30 | 2005-12-08 | H. Lundbeck A/S | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives |
GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
JP4544820B2 (en) * | 2001-03-09 | 2010-09-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Heterocyclic compounds |
AU2003265886A1 (en) | 2002-09-06 | 2004-03-29 | Janssen Pharmaceutica N.V. | (1H-Benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders |
WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
WO2005095338A1 (en) | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Fast Dissociting Dopamine 2 Receptor Antagonists |
JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Fast Dissociating Dopamine 2 Receptor Antagonists |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Fast -Dissociating Dopamine 2 Receptor Antagonists |
MX2009011415A (en) | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists. |
CA2682671C (en) | 2007-04-23 | 2015-11-17 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
JP5417439B2 (en) | 2008-07-03 | 2014-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Substituted 6- (1-piperazinyl) -pyridazines as 5-HT6 receptor antagonists |
CN102171189B (en) | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
CN109843872B (en) * | 2017-09-20 | 2022-08-30 | 杭州英创医药科技有限公司 | Polycyclic compounds as IDO inhibitors and/or IDO-HDAC dual inhibitors |
WO2021216665A1 (en) * | 2020-04-22 | 2021-10-28 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB944443A (en) * | 1959-09-25 | 1900-01-01 | ||
EP0594702B1 (en) * | 1991-07-03 | 1997-01-29 | PHARMACIA & UPJOHN COMPANY | Substituted indoles as anti-aids pharmaceuticals |
JPH05255089A (en) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | Antiviral agent |
JPH08502958A (en) * | 1992-10-23 | 1996-04-02 | メルク シヤープ エンド ドーム リミテツド | Dopamine receptor subtype ligand |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
DE4414113A1 (en) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-indolylpiperidines |
TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Application Discontinuation
- 1998-08-05 EA EA200000023A patent/EA200000023A1/en unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/en not_active Application Discontinuation
- 1998-08-05 ID IDW20000197A patent/ID23803A/en unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/en active Pending
- 1998-08-05 IL IL13396098A patent/IL133960A0/en unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 CN CN98807831A patent/CN1265660A/en active Pending
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/en not_active IP Right Cessation
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/en unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/en unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 PL PL98338947A patent/PL338947A1/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/en unknown
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/en unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/en not_active Application Discontinuation
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/en unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/en active
- 1998-08-12 MA MA25210A patent/MA24632A1/en unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/en unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/en not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/en unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/en unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/en not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/en unknown
- 2000-01-11 IS IS5336A patent/IS5336A/en unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20000722D0 (en) | 2000-02-14 |
HRP980441A2 (en) | 1999-04-30 |
SK1352000A3 (en) | 2000-08-14 |
UY25144A1 (en) | 2000-12-29 |
IL133960A0 (en) | 2001-04-30 |
ZA987304B (en) | 2000-02-14 |
ID23803A (en) | 2000-05-11 |
PA8457001A1 (en) | 2000-09-29 |
CO4960656A1 (en) | 2000-09-25 |
JP2002536291A (en) | 2002-10-29 |
HUP0003425A3 (en) | 2002-02-28 |
WO1999009025A3 (en) | 1999-04-15 |
AP9801321A0 (en) | 2000-02-14 |
KR20010022507A (en) | 2001-03-15 |
BR9811557A (en) | 2000-08-22 |
MA24632A1 (en) | 1999-04-01 |
CA2297486C (en) | 2005-05-03 |
WO1999009025A2 (en) | 1999-02-25 |
BG104069A (en) | 2001-05-31 |
DZ2583A1 (en) | 2003-02-22 |
HUP0003425A2 (en) | 2001-10-28 |
PE106299A1 (en) | 1999-11-02 |
EP1003739A2 (en) | 2000-05-31 |
OA11286A (en) | 2003-10-22 |
AR017019A1 (en) | 2001-08-22 |
NO20000722L (en) | 2000-02-14 |
IS5336A (en) | 2000-01-11 |
TNSN98151A1 (en) | 2005-03-15 |
TR200000414T2 (en) | 2000-08-21 |
CA2297486A1 (en) | 1999-02-25 |
AU8457298A (en) | 1999-03-08 |
PL338947A1 (en) | 2000-12-04 |
CN1265660A (en) | 2000-09-06 |
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