CO4960656A1 - DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) 1H- INDOL - Google Patents
DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) 1H- INDOLInfo
- Publication number
- CO4960656A1 CO4960656A1 CO98046788A CO98046788A CO4960656A1 CO 4960656 A1 CO4960656 A1 CO 4960656A1 CO 98046788 A CO98046788 A CO 98046788A CO 98046788 A CO98046788 A CO 98046788A CO 4960656 A1 CO4960656 A1 CO 4960656A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- hydrogen
- cyano
- nitrogen
- trifluoromethyl
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 7
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001246 bromo group Chemical group Br* 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- 101100495911 Arabidopsis thaliana CHR10 gene Proteins 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula I:o la sal farmacéuticamente aceptable del mismo, donde la línea discontinua representa un doble enlace opcional; a es O ó 1, en el que cuando a es O, X puede formar un doble enlace opcional con el carbono adyacente a V; V es CHR10 , en el que R10 es hidrógeno o alquilo (C1 -C6 ); T es nitrógeno o CH; X es nitrógeno o CR11 , en el que R11 es hidrógeno, alquilo (C1 -C6 ), alcoxi (C1 -C6 ), hidroxi o ciano; Y y Z son cada uno de ellos independientemente nitrógeno o CR12 , en el que R12 es hidrógeno, cloro, bromo, trifluorometilo, trifluorometoxi, ciano, alcoxi (C1 -C6 ) o alquilo (C1 -C6 ); R1 es hidrógeno, fluoro, cloro, bromo, trifluorometilo, trifluorometoxi, ciano o alquilo (C1 -C6 ); R2 , R6 , R7 , R8 y R9 están cada uno de ellos independientemente seleccionados entre hidrógeno, fluoro, cloro, bromo, trifluorometilo, trifluorometoxi, ciano, alcoxi (C1 -C6 ) y alquilo (C1 -C6 ); R3 y R4 son cada uno de ellos independientemente hidrógeno o alquilo (C1 -C6 ); y R5 es hidrógeno, alcoxi (C1 -C6 ), trifluorometilo, ciano, alquilo (C1 -C6 ) o R13 CO, en el que R13 es amino, alquil(C1 -C6 )amino, (alquilo (C1 -C6 ))2 amino, alquilo (C1 -C6 ), arilo (C6 -C10 );o cuando a es 1, R1 y R10 se pueden unir con los carbonos a los que están unidos para formar un compuesto de fórmula en la que las líneas discontinuas representan enlaces opcionales; T, X, Y, Z, R2 , R3 , R4 , R5 , R6 , R7 , R8 y R9 son lo definido anteriormente; b es O ó 1; y A y B son cada uno de ellos independientemente CH, CH2 , oxígeno, azufre, NH o nitrógeno; con la condición de que cuando X es nitrógeno, el doble enlace opcional entre X y V no existe; con la condición de que cuando b es O, el doble enlace opcional entre A y B no existe; y con la condición de que cuando b es 1, A y B no pueden ser ninguno de ellos oxígeno o azufre.A compound of formula I: or the pharmaceutically acceptable salt thereof, where the broken line represents an optional double bond; a is O or 1, where when a is O, X can form an optional double bond with the carbon adjacent to V; V is CHR10, where R10 is hydrogen or (C1-C6) alkyl; T is nitrogen or CH; X is nitrogen or CR11, where R11 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy, hydroxy or cyano; Y and Z are each independently nitrogen or CR12, where R12 is hydrogen, chlorine, bromine, trifluoromethyl, trifluoromethoxy, cyano, (C1-C6) alkoxy or (C1-C6) alkyl; R1 is hydrogen, fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, cyano or (C1-C6) alkyl; R2, R6, R7, R8 and R9 are each independently selected from hydrogen, fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, cyano, C1-C6 alkoxy and (C1-C6) alkyl; R3 and R4 are each independently hydrogen or (C1-C6) alkyl; and R5 is hydrogen, (C1-C6) alkoxy, trifluoromethyl, cyano, (C1-C6) alkyl or R13 CO, where R13 is amino, (C1-C6) alkyl, ((C1-C6) alkyl) 2 amino, (C1-C6) alkyl, (C6 -C10) aryl; or when a is 1, R1 and R10 may join with the carbons to which they are attached to form a compound of formula in which the dashed lines represent bonds optional; T, X, Y, Z, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined above; b is O or 1; and A and B are each independently CH, CH2, oxygen, sulfur, NH or nitrogen; with the proviso that when X is nitrogen, the optional double bond between X and V does not exist; with the proviso that when b is O, the optional double bond between A and B does not exist; and with the proviso that when b is 1, A and B cannot be either oxygen or sulfur.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5576497P | 1997-08-15 | 1997-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4960656A1 true CO4960656A1 (en) | 2000-09-25 |
Family
ID=22000003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98046788A CO4960656A1 (en) | 1997-08-15 | 1998-08-14 | DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) 1H- INDOL |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1003739A2 (en) |
| JP (1) | JP2002536291A (en) |
| KR (1) | KR20010022507A (en) |
| CN (1) | CN1265660A (en) |
| AP (1) | AP9801321A0 (en) |
| AR (1) | AR017019A1 (en) |
| AU (1) | AU8457298A (en) |
| BG (1) | BG104069A (en) |
| BR (1) | BR9811557A (en) |
| CA (1) | CA2297486C (en) |
| CO (1) | CO4960656A1 (en) |
| DZ (1) | DZ2583A1 (en) |
| EA (1) | EA200000023A1 (en) |
| HR (1) | HRP980441A2 (en) |
| HU (1) | HUP0003425A3 (en) |
| ID (1) | ID23803A (en) |
| IL (1) | IL133960A0 (en) |
| IS (1) | IS5336A (en) |
| MA (1) | MA24632A1 (en) |
| NO (1) | NO20000722D0 (en) |
| OA (1) | OA11286A (en) |
| PA (1) | PA8457001A1 (en) |
| PE (1) | PE106299A1 (en) |
| PL (1) | PL338947A1 (en) |
| SK (1) | SK1352000A3 (en) |
| TN (1) | TNSN98151A1 (en) |
| TR (1) | TR200000414T2 (en) |
| UY (1) | UY25144A1 (en) |
| WO (1) | WO1999009025A2 (en) |
| ZA (1) | ZA987304B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9813279B1 (en) * | 1997-10-27 | 2010-11-16 | homopiperazine derivative, pharmaceutical composition, and use of the homopiperazine derivative. | |
| EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
| PT1464641E (en) | 1999-12-30 | 2008-07-01 | Lundbeck & Co As H | 4-phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine d4 antagonists |
| GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
| EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
| MXPA03008143A (en) * | 2001-03-09 | 2005-08-16 | Johnson & Johnson | Heterocyclic compounds. |
| WO2004022060A2 (en) | 2002-09-06 | 2004-03-18 | Janssen Pharmaceutica, N.V. | (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| EP2253315A1 (en) | 2004-03-30 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
| US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
| JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Fast Dissociting Dopamine 2 Receptor Antagonists |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Fast Dissociating Dopamine 2 Receptor Antagonists |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Fast -Dissociating Dopamine 2 Receptor Antagonists |
| JP5431306B2 (en) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Thia (dia) zole as a fast dissociating dopamine 2 receptor antagonist |
| PT2148873E (en) | 2007-04-23 | 2012-11-20 | Janssen Pharmaceutica Nv | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| RU2502734C2 (en) | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
| HUE033768T2 (en) | 2008-07-31 | 2017-12-28 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| JP2020534336A (en) * | 2017-09-20 | 2020-11-26 | ハンジョウ イノゲート ファーマ カンパニー リミテッドHangzhou Innogate Pharma Co., Ltd. | Polycyclic compounds as IDO inhibitors and / or IDO-HDAC double inhibitors |
| AU2021259580A1 (en) * | 2020-04-22 | 2022-11-24 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (en) * | 1959-09-25 | 1900-01-01 | ||
| ES2097341T3 (en) * | 1991-07-03 | 1997-04-01 | Upjohn Co | SUBSTITUTED INDOLES AS DRUGS FOR THE TREATMENT OF AIDS. |
| JPH05255089A (en) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | Antiviral agent |
| WO1994010162A1 (en) * | 1992-10-23 | 1994-05-11 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
| GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
| AU6435594A (en) * | 1993-04-15 | 1994-11-08 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
| DE4414113A1 (en) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-indolylpiperidines |
| TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
| ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 EA EA200000023A patent/EA200000023A1/en unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/en unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/en active Pending
- 1998-08-05 ID IDW20000197A patent/ID23803A/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/en unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/en active Pending
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Application Discontinuation
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/en not_active IP Right Cessation
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 IL IL13396098A patent/IL133960A0/en unknown
- 1998-08-05 PL PL98338947A patent/PL338947A1/en unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/en not_active Application Discontinuation
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/en unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/en unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/en not_active Application Discontinuation
- 1998-08-12 MA MA25210A patent/MA24632A1/en unknown
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/en unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/en active
- 1998-08-13 AR ARP980104021A patent/AR017019A1/en unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/en unknown
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/en unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/en not_active Application Discontinuation
- 1998-08-17 UY UY25144A patent/UY25144A1/en not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/en unknown
- 2000-01-11 IS IS5336A patent/IS5336A/en unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AP9801321A0 (en) | 2000-02-14 |
| KR20010022507A (en) | 2001-03-15 |
| AR017019A1 (en) | 2001-08-22 |
| EA200000023A1 (en) | 2000-08-28 |
| CA2297486A1 (en) | 1999-02-25 |
| ID23803A (en) | 2000-05-11 |
| AU8457298A (en) | 1999-03-08 |
| NO20000722L (en) | 2000-02-14 |
| UY25144A1 (en) | 2000-12-29 |
| HRP980441A2 (en) | 1999-04-30 |
| OA11286A (en) | 2003-10-22 |
| MA24632A1 (en) | 1999-04-01 |
| TNSN98151A1 (en) | 2005-03-15 |
| BR9811557A (en) | 2000-08-22 |
| JP2002536291A (en) | 2002-10-29 |
| PL338947A1 (en) | 2000-12-04 |
| NO20000722D0 (en) | 2000-02-14 |
| BG104069A (en) | 2001-05-31 |
| PA8457001A1 (en) | 2000-09-29 |
| TR200000414T2 (en) | 2000-08-21 |
| HUP0003425A3 (en) | 2002-02-28 |
| ZA987304B (en) | 2000-02-14 |
| WO1999009025A3 (en) | 1999-04-15 |
| CN1265660A (en) | 2000-09-06 |
| CA2297486C (en) | 2005-05-03 |
| PE106299A1 (en) | 1999-11-02 |
| HUP0003425A2 (en) | 2001-10-28 |
| WO1999009025A2 (en) | 1999-02-25 |
| IS5336A (en) | 2000-01-11 |
| EP1003739A2 (en) | 2000-05-31 |
| SK1352000A3 (en) | 2000-08-14 |
| DZ2583A1 (en) | 2003-02-22 |
| IL133960A0 (en) | 2001-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4960656A1 (en) | DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) 1H- INDOL | |
| CO4650135A1 (en) | LACTAMS AND HETERO-CYCLIC IMIDES OF ARALQUILO AND ARALQUILIDENO | |
| CO4600634A1 (en) | DERIVATIVES 6,5-HETEROBICICLICOS SUBSTITUTED | |
| CO5310534A1 (en) | NEW ANDROSTAN ANTI-INFLAMMATORY DERIVATIVES | |
| CO4990956A1 (en) | DERIVATIVES OF THENOPyrimidine AND THENOPyridine USEFUL AS ANTI-CANCER AGENTS | |
| CO5271658A1 (en) | CORTICOTROPINE RELEASE FACTOR ANTAGONISTS | |
| CO5721002A2 (en) | ACID DERIVATIVES 3- (4-BENCILOXIFENIL) PROPANOIC | |
| AR090649A2 (en) | HEPATITIS C VIRUS INHIBITORS | |
| CO4970713A1 (en) | DERIVATIVES OF CARBOXAMIDOTIAZOLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM | |
| CO4940458A1 (en) | NOVEL INHIBITORS OF N-SUBSTITUTED UREA FOR PROTEIN TRANSFERASE FARNESILO | |
| CO4650033A1 (en) | LACTAM DERIVATIVES WITH SELECTIVE AGONIST AND ANTAGONIST ACTIVITY OF SEROTONIN 1 RECEPTORS (5HT) AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| AR021534A1 (en) | DERIVATIVES OF 1,4-DIAZABICICLO [3.2.2] NONANO, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS | |
| NI200800008A (en) | METHODS FOR NEUROPROTECTION | |
| CO4900059A1 (en) | 3- UREIDO-PIRIDOFURANOS y- PIRIDOTIOFENOS | |
| CO5550440A2 (en) | DERIVATIVES OF 1-PHENYL SULFONIL-1,3-DIHIDRO-2H-INDOL-2-ONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS | |
| EA200300777A1 (en) | N-PHENPROPYL CYCLOPENTHYL-SUBSTITUTED GLUTARAMIDE DERIVATIVES AS NEP INHIBITORS FOR FSAD | |
| CO5060482A1 (en) | BIARILO THERAPEUTIC DERIVATIVES | |
| UY25986A1 (en) | RAS-FARNESILTRANSFERASE AND SULFOBUTYLETHER-7-BETA-CYCLODEXTRIN OR 2-HYDROXYPROPIL-BETA-CYCLODEXTRIN AND METHOD INHIBITOR COMPLEX. | |
| AR065795A1 (en) | DERIVATIVES OF AZA-PYRIDOPIRIMIDINONE, METHOD OF PREPARATION, MEDICINES CONTAINING THEM AND USES AS ANTHROMBROTIC, ANTI-HEROPHYPE AND ANTI-DIABETIC AGENTS, AMONG OTHERS. | |
| CO4950561A1 (en) | ERGOLINE DERIVATIVES | |
| EA200401470A1 (en) | DERIVATIVES OF PIPERAZINYLACYLIPIPERIDINE, THEIR RECEIVING AND THEIR THERAPEUTIC APPLICATION | |
| EA200400748A1 (en) | RECEPTOR AGONISTS ACTIVATED BY PEROXISOMIC PROLIFERATOR | |
| AR024918A1 (en) | CYCLLOBUTEN DERIVATIVES, ITS PREPARATION AND THERAPEUTIC USES. | |
| AR002072A1 (en) | PROCESS FOR THE PREPARATION OF PIRROLIDIN-2-ONA DERIVATIVES USEFUL AS INTERMEDIARIES IN THE SYNTHESIS OF HERBICIDES. | |
| BG104471A (en) | Benzylidene pyrazolones, their preparation and use as herbicides |