TNSN98151A1 - DERIVATIVES OF 2 - (4 - ARYL - OR HETEROARYL - PIPERAZINE - 1 - YLMETHYL) -1 H - INDOLE. - Google Patents

DERIVATIVES OF 2 - (4 - ARYL - OR HETEROARYL - PIPERAZINE - 1 - YLMETHYL) -1 H - INDOLE.

Info

Publication number
TNSN98151A1
TNSN98151A1 TNTNSN98151A TNSN98151A TNSN98151A1 TN SN98151 A1 TNSN98151 A1 TN SN98151A1 TN TNSN98151 A TNTNSN98151 A TN TNSN98151A TN SN98151 A TNSN98151 A TN SN98151A TN SN98151 A1 TNSN98151 A1 TN SN98151A1
Authority
TN
Tunisia
Prior art keywords
ylmethyl
indole
piperazine
heteroaryl
aryl
Prior art date
Application number
TNTNSN98151A
Other languages
French (fr)
Inventor
Howard Zorn Stevin
Rollema Hans
Franz Josef Fliri Anton
Jerome Majchrzak Mark
Ann Seymour Patricia
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN98151A1 publication Critical patent/TNSN98151A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE UN COMPOSE DE FORMULE.DANS LAQUELLE a EST EGAL A 0 OU 1 ET T,V,X,Y,Z,R1,R2,R3,R4,R5,R6,R7,R8, et R9 REPRESENTENT DIVERS RADICAUX, ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION :UTILISATION DE CES COMPOSES ET COMPOSITIONS, A ACTIVITE DOPAMINERGIQUE CENTRALE, DANS LE TRAITEMENT DE TROUBLES DU SYSTEME NERVEUX CENTRAL.THE INVENTION CONCERNS A COMPOUND OF FORMULA IN WHICH a IS EQUAL TO 0 OR 1 AND T, V, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, and R9 REPRESENT VARIOUS RADICALS , AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS. IT ALSO CONCERNS A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. APPLICATION: USE OF THESE COMPOUNDS AND COMPOSITIONS, WITH CENTRAL DOPAMINERGIC ACTIVITY, IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM.

TNTNSN98151A 1997-08-15 1998-08-12 DERIVATIVES OF 2 - (4 - ARYL - OR HETEROARYL - PIPERAZINE - 1 - YLMETHYL) -1 H - INDOLE. TNSN98151A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5576497P 1997-08-15 1997-08-15

Publications (1)

Publication Number Publication Date
TNSN98151A1 true TNSN98151A1 (en) 2005-03-15

Family

ID=22000003

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98151A TNSN98151A1 (en) 1997-08-15 1998-08-12 DERIVATIVES OF 2 - (4 - ARYL - OR HETEROARYL - PIPERAZINE - 1 - YLMETHYL) -1 H - INDOLE.

Country Status (30)

Country Link
EP (1) EP1003739A2 (en)
JP (1) JP2002536291A (en)
KR (1) KR20010022507A (en)
CN (1) CN1265660A (en)
AP (1) AP9801321A0 (en)
AR (1) AR017019A1 (en)
AU (1) AU8457298A (en)
BG (1) BG104069A (en)
BR (1) BR9811557A (en)
CA (1) CA2297486C (en)
CO (1) CO4960656A1 (en)
DZ (1) DZ2583A1 (en)
EA (1) EA200000023A1 (en)
HR (1) HRP980441A2 (en)
HU (1) HUP0003425A3 (en)
ID (1) ID23803A (en)
IL (1) IL133960A0 (en)
IS (1) IS5336A (en)
MA (1) MA24632A1 (en)
NO (1) NO20000722L (en)
OA (1) OA11286A (en)
PA (1) PA8457001A1 (en)
PE (1) PE106299A1 (en)
PL (1) PL338947A1 (en)
SK (1) SK1352000A3 (en)
TN (1) TNSN98151A1 (en)
TR (1) TR200000414T2 (en)
UY (1) UY25144A1 (en)
WO (1) WO1999009025A2 (en)
ZA (1) ZA987304B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285198B6 (en) * 1997-10-27 2006-08-03 Neurosearch A/S Homopiperazine derivative, pharmaceutical composition containing this derivative and using of it
EP0953567A3 (en) 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
WO2001049679A1 (en) * 1999-12-30 2001-07-12 H. Lundbeck A/S 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
GB0017952D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of dyskinesia
EP1177792A3 (en) 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
US6803362B2 (en) 2001-03-09 2004-10-12 Ortho-Mcneil Pharmaceutical Inc. Heterocyclic compounds
CA2497827A1 (en) 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
US7517910B2 (en) 2004-03-30 2009-04-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
US7618980B2 (en) 2004-07-14 2009-11-17 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5HT ligands
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Fast Dissociting Dopamine 2 Receptor Antagonists
JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Fast Dissociating Dopamine 2 Receptor Antagonists
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Fast -Dissociating Dopamine 2 Receptor Antagonists
AU2008240729B2 (en) 2007-04-23 2012-08-23 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
DK2148873T3 (en) 2007-04-23 2012-11-26 Janssen Pharmaceutica Nv 4-ALKOXYPYRIDAZINE DERIVATIVES AS QUICK DISSOCATING DOPAMINE 2- RECEPTOR ANTAGONISTS
ES2398625T3 (en) 2008-07-03 2013-03-20 Janssen Pharmaceutica N.V. 6- (1-Piperazinyl) -pyritazines substituted as 5-HT6 receptor antagonists
ES2622161T3 (en) 2008-07-31 2017-07-05 Janssen Pharmaceutica, N.V. Piperazin-1-yl-trifluoromethyl substituted pyridines as fast dissociation dopamine 2 receptor antagonists
EP3686196B1 (en) * 2017-09-20 2024-06-12 Hangzhou Innogate Pharma Co., Ltd. Polycyclic compound acting as ido inhibitor and/or ido-hdac dual inhibitor
JP2023523176A (en) * 2020-04-22 2023-06-02 アニマ バイオテック インコーポレイテッド COLLAGEN 1 TRANSLATION INHIBITOR AND METHOD OF USE THEREOF

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (en) * 1959-09-25 1900-01-01
WO1993001181A1 (en) * 1991-07-03 1993-01-21 The Upjohn Company Substituted indoles as anti-aids pharmaceuticals
JPH05255089A (en) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd Antiviral agent
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
AU6215594A (en) * 1993-03-18 1994-10-11 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
AU6435594A (en) * 1993-04-15 1994-11-08 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
DE4414113A1 (en) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-indolylpiperidines
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives

Also Published As

Publication number Publication date
MA24632A1 (en) 1999-04-01
NO20000722D0 (en) 2000-02-14
CO4960656A1 (en) 2000-09-25
OA11286A (en) 2003-10-22
JP2002536291A (en) 2002-10-29
UY25144A1 (en) 2000-12-29
AP9801321A0 (en) 2000-02-14
PL338947A1 (en) 2000-12-04
BG104069A (en) 2001-05-31
CA2297486C (en) 2005-05-03
HRP980441A2 (en) 1999-04-30
IL133960A0 (en) 2001-04-30
ZA987304B (en) 2000-02-14
CA2297486A1 (en) 1999-02-25
AU8457298A (en) 1999-03-08
DZ2583A1 (en) 2003-02-22
PE106299A1 (en) 1999-11-02
IS5336A (en) 2000-01-11
WO1999009025A3 (en) 1999-04-15
EA200000023A1 (en) 2000-08-28
AR017019A1 (en) 2001-08-22
WO1999009025A2 (en) 1999-02-25
PA8457001A1 (en) 2000-09-29
TR200000414T2 (en) 2000-08-21
ID23803A (en) 2000-05-11
HUP0003425A2 (en) 2001-10-28
HUP0003425A3 (en) 2002-02-28
CN1265660A (en) 2000-09-06
NO20000722L (en) 2000-02-14
SK1352000A3 (en) 2000-08-14
BR9811557A (en) 2000-08-22
KR20010022507A (en) 2001-03-15
EP1003739A2 (en) 2000-05-31

Similar Documents

Publication Publication Date Title
TNSN98151A1 (en) DERIVATIVES OF 2 - (4 - ARYL - OR HETEROARYL - PIPERAZINE - 1 - YLMETHYL) -1 H - INDOLE.
TNSN96172A1 (en) HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TNSN97055A1 (en) 6-PHENYLPYRIDYL -2-AMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TNSN98237A1 (en) AZAPOLYCYCLIC COMPOUNDS WITH CONDENSED ARYL CORE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN99236A1 (en) NOVEL SUBSTITUTED BICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TNSN00104A1 (en) NOVEL ISOTHIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN98083A1 (en) 6-0 METHYLERYTHROMYCIN A DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TNSN97110A1 (en) DERIVATIVES OF 2- (2-OXO-ETHYLIDENE) -IMIDAZOLIDINE-4-ONE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26718A1 (en) NEW HETEROARYL SUBSTITUTE QUINOLEIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN99169A1 (en) NOVEL 4,4-BIARYLPIPERIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN05165A1 (en) PYRROLOPYRIMIDINE DERIVATIVES
TNSN98150A1 (en) DERIVATIVES OF ARYLOXYARYLSULFONYLAMINOHYDROXAMIC ACIDS; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN97122A1 (en) INHIBITORS OF PHOSPHINATE MATRIX METALLOPROTEINASES
TNSN97198A1 (en) 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN97087A1 (en) NOVEL 4 (3H) -QUINAZOLINONES 2,3-DISUBSTITUTED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN98112A1 (en) DIPEPTIDE COMPOUNDS
TNSN97044A1 (en) QUINOXALINEDONE DERIVATIVES, METHODS AND INTERMEDIATES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
MA25035A1 (en) NEW 3-AZABICYCLO [3,1,0] HEXANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
TNSN98035A1 (en) ATROPISOMERS OF 3-ARYL-4 (3H) -QUINAZOLINONES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
TNSN99142A1 (en) NOVEL BENZIMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.
TNSN99171A1 (en) 4-CARBOXYAMINO-2-SUBSTITUE-1,2,3,4-TETRAHYDROQUINOLEINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TNSN96161A1 (en) NOVEL QUINOLEINE AND QUINAZOLINE DERIVATIVES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM.
DE69613365D1 (en) ESTER OF 5-AMINOLEVULINIC ACID AS A MEANS FOR PHOTOSENSITIZATION IN CHEMOTHERAPY
TNSN98084A1 (en) DERIVATIVES OF SUBSTITUTED MACROLIDES IN POSITION C-4
TNSN98024A1 (en) 2-AMINO-6- (2-SUBSTITUE-4-PHENOXY) -SUBSTITUE-PYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.