EA202193322A1 - Конструирование шарнирной области для управления димеризацией антител - Google Patents

Конструирование шарнирной области для управления димеризацией антител

Info

Publication number
EA202193322A1
EA202193322A1 EA202193322A EA202193322A EA202193322A1 EA 202193322 A1 EA202193322 A1 EA 202193322A1 EA 202193322 A EA202193322 A EA 202193322A EA 202193322 A EA202193322 A EA 202193322A EA 202193322 A1 EA202193322 A1 EA 202193322A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dimer
construction
hinge region
mutations
heavy chains
Prior art date
Application number
EA202193322A
Other languages
English (en)
Russian (ru)
Inventor
Фернандо Гарсес
Чжулунь Ван
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA202193322A1 publication Critical patent/EA202193322A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EA202193322A 2019-05-30 2020-05-29 Конструирование шарнирной области для управления димеризацией антител EA202193322A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962854907P 2019-05-30 2019-05-30
PCT/US2020/035196 WO2020243477A2 (en) 2019-05-30 2020-05-29 Engineering the hinge region to drive antibody dimerization

Publications (1)

Publication Number Publication Date
EA202193322A1 true EA202193322A1 (ru) 2022-03-10

Family

ID=72234906

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202193322A EA202193322A1 (ru) 2019-05-30 2020-05-29 Конструирование шарнирной области для управления димеризацией антител

Country Status (12)

Country Link
US (1) US12612468B2 (https=)
EP (1) EP3976643A2 (https=)
JP (2) JP7500619B2 (https=)
KR (1) KR20220016139A (https=)
CN (2) CN119431599A (https=)
AU (1) AU2020283890A1 (https=)
CA (1) CA3141690A1 (https=)
EA (1) EA202193322A1 (https=)
MX (3) MX2021014534A (https=)
SG (1) SG11202112926YA (https=)
TW (2) TWI879770B (https=)
WO (1) WO2020243477A2 (https=)

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CN110669137B (zh) * 2019-10-24 2021-07-16 高新 一种多特异性抗体及其制备方法和用途
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JP2025524024A (ja) * 2022-07-22 2025-07-25 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 多重特異性抗体の重鎖及び軽鎖の相同対合を促進する変異体
CN115232214A (zh) * 2022-08-16 2022-10-25 广州市拜沃思生物科技有限公司 一种双特异性抗体及其制备方法和应用
TW202506725A (zh) * 2023-04-07 2025-02-16 美商麥迪紐有限責任公司 三特異性工程化抗體
KR20260015834A (ko) * 2023-05-24 2026-02-03 삼성바이오로직스 주식회사 Ch3 도메인 변이체 또는 이를 포함하는 이중 특이적 항체
WO2025167974A1 (zh) * 2024-02-07 2025-08-14 上海齐鲁制药研究中心有限公司 多特异性抗体或抗原结合片段

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Also Published As

Publication number Publication date
WO2020243477A3 (en) 2021-01-07
WO2020243477A2 (en) 2020-12-03
MX2021014534A (es) 2022-02-11
TW202525844A (zh) 2025-07-01
SG11202112926YA (en) 2021-12-30
US12612468B2 (en) 2026-04-28
CN114174344A (zh) 2022-03-11
US20220235148A1 (en) 2022-07-28
TW202110877A (zh) 2021-03-16
KR20220016139A (ko) 2022-02-08
MX2026002465A (es) 2026-04-01
TWI879770B (zh) 2025-04-11
CN119431599A (zh) 2025-02-14
AU2020283890A1 (en) 2021-12-16
CN114174344B (zh) 2024-11-22
JP7835796B2 (ja) 2026-03-25
JP2022534901A (ja) 2022-08-04
JP2024113040A (ja) 2024-08-21
EP3976643A2 (en) 2022-04-06
JP7500619B2 (ja) 2024-06-17
CA3141690A1 (en) 2020-12-03
MX2026002466A (es) 2026-04-01

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