EA202192931A1 - Способ прогнозирования эффективности лечения гемоглобинопатии - Google Patents

Способ прогнозирования эффективности лечения гемоглобинопатии

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Publication number
EA202192931A1
EA202192931A1 EA202192931A EA202192931A EA202192931A1 EA 202192931 A1 EA202192931 A1 EA 202192931A1 EA 202192931 A EA202192931 A EA 202192931A EA 202192931 A EA202192931 A EA 202192931A EA 202192931 A1 EA202192931 A1 EA 202192931A1
Authority
EA
Eurasian Patent Office
Prior art keywords
modified
individual
treatment
population
hemoglobinopathy
Prior art date
Application number
EA202192931A
Other languages
English (en)
Russian (ru)
Inventor
Жиго Фан
Линлин Юй
Хуэйхуэй ЯН
Original Assignee
Эдиджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эдиджен Инк. filed Critical Эдиджен Инк.
Publication of EA202192931A1 publication Critical patent/EA202192931A1/ru

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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EA202192931A 2019-04-30 2020-04-29 Способ прогнозирования эффективности лечения гемоглобинопатии EA202192931A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019085116 2019-04-30
PCT/CN2020/087766 WO2020221291A1 (zh) 2019-04-30 2020-04-29 一种血红蛋白病治疗有效性预测方法

Publications (1)

Publication Number Publication Date
EA202192931A1 true EA202192931A1 (ru) 2022-02-22

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US (1) US20220193142A1 (enExample)
EP (1) EP3964579A4 (enExample)
JP (1) JP2022531269A (enExample)
KR (1) KR20220002565A (enExample)
CN (1) CN113785059A (enExample)
AU (1) AU2020265060A1 (enExample)
BR (1) BR112021021744A8 (enExample)
CA (1) CA3138029A1 (enExample)
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CO (1) CO2021016058A2 (enExample)
CR (1) CR20210591A (enExample)
EA (1) EA202192931A1 (enExample)
IL (1) IL287672A (enExample)
MA (1) MA55817A (enExample)
MX (1) MX2021013363A (enExample)
PE (1) PE20220003A1 (enExample)
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CR20210572A (es) 2019-04-15 2022-04-07 Univ Beijing Métodos y composiciones para editar ácido ribonucleicos (arn)
MX2022000497A (es) 2019-07-12 2022-02-03 Univ Beijing Edicion de acido ribonucleico (arn) dirigido aprovechando la adenosina desaminasa que actua sobre acido ribonucleico endogeno (adar) utilizando acidos ribonucleicos (arn) modificados geneticamente.
BR112023019773A2 (pt) * 2021-04-02 2024-03-12 Univ Shanghai Technology Método para promover a produção de gama-globina em uma célula humana, polinucleotídeos codificando uma proteína associada a um crispr (cas), uma nucleobase desaminase, um rna de guia único (sgrna) e um rna de guia único auxiliar (hsgrna), e, proteína de fusão

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SG11201405103SA (en) * 2012-02-24 2014-09-26 Hutchinson Fred Cancer Res Compositions and methods for the treatment of hemoglobinopathies
MY189533A (en) 2012-05-25 2022-02-16 Univ California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
KR20230065381A (ko) 2012-07-25 2023-05-11 더 브로드 인스티튜트, 인코퍼레이티드 유도 ｄｎａ 결합 단백질 및 게놈 교란 도구 및 이의 적용
WO2014065596A1 (en) 2012-10-23 2014-05-01 Toolgen Incorporated Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
PT3502240T (pt) * 2012-11-27 2021-08-11 Childrens Medical Ct Corp Elementos reguladores distais de bcl11a como alvo para a reindução de hemoglobina fetal
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
WO2016135558A2 (en) * 2015-02-23 2016-09-01 Crispr Therapeutics Ag Materials and methods for treatment of hemoglobinopathies
SG11201805217XA (en) * 2015-12-28 2018-07-30 Novartis Ag Compositions and methods for the treatment of hemoglobinopathies
TW201839136A (zh) * 2017-02-06 2018-11-01 瑞士商諾華公司 治療血色素異常症之組合物及方法
US11788087B2 (en) * 2017-05-25 2023-10-17 The Children's Medical Center Corporation BCL11A guide delivery

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CA3138029A1 (en) 2020-11-05
WO2020221291A1 (zh) 2020-11-05
PH12021552732A1 (en) 2023-01-16
IL287672A (en) 2021-12-01
MA55817A (fr) 2022-03-09
JP2022531269A (ja) 2022-07-06
CN113785059A (zh) 2021-12-10
BR112021021744A8 (pt) 2023-03-21
US20220193142A1 (en) 2022-06-23
CR20210591A (es) 2022-03-11
KR20220002565A (ko) 2022-01-06
SG11202112072QA (en) 2021-12-30
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CL2021002854A1 (es) 2022-08-12
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BR112021021744A2 (enExample) 2021-12-28
AU2020265060A1 (en) 2021-12-16
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