EA202191398A1 - 6-6-конденсированные бициклические гетероарильные соединения и их применение в качестве ингибиторов lats - Google Patents

6-6-конденсированные бициклические гетероарильные соединения и их применение в качестве ингибиторов lats

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Publication number
EA202191398A1
EA202191398A1 EA202191398A EA202191398A EA202191398A1 EA 202191398 A1 EA202191398 A1 EA 202191398A1 EA 202191398 A EA202191398 A EA 202191398A EA 202191398 A EA202191398 A EA 202191398A EA 202191398 A1 EA202191398 A1 EA 202191398A1
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EA
Eurasian Patent Office
Prior art keywords
present
bicyclic heteroaryl
heteroaryl compounds
condensed bicyclic
lats
Prior art date
Application number
EA202191398A
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English (en)
Inventor
Дирк Бенке
Фрада Беренштейн
Сюэши Хао
Тимоти Хоффман
Цихой Цзинь
Арно Лакост
Камерон Ли
Цзюнь ЛЮ
Яху Лю
Юрген Клаус Майбаум
Тинтин Мо
Цзяньфэн Пань
Синь Цюй
Ян Тхож
Юнь Фэн Се
Шаньшань Янь
Ефэнь Цзоу
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA202191398A1 publication Critical patent/EA202191398A1/ru

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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Настоящее изобретение относится к 6-6-конденсированным бициклическим гетероарильным соединениям формулы А2 или А1 и к их применению в качестве ингибиторов LATS, или к их соли, стереоизомеру или фармацевтической композиции; где переменные определены в данном документе.Настоящее изобретение дополнительно относится к способу ингибирования LATS в популяции клеток с использованием соединения формулы А1 или его соли, стереоизомера или фармацевтической композиции. В настоящем изобретении дополнительно представлены способ изготовления соединений по настоящему изобретению и их терапевтические применения. В настоящем изобретении дополнительно представлены способы их получения, их применение в медицине, их применение в лечении и контроле заболеваний или нарушений.
EA202191398A 2018-03-29 2018-04-26 6-6-конденсированные бициклические гетероарильные соединения и их применение в качестве ингибиторов lats EA202191398A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862650232P 2018-03-29 2018-03-29

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EA202191398A1 true EA202191398A1 (ru) 2021-09-08

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EA202191398A EA202191398A1 (ru) 2018-03-29 2018-04-26 6-6-конденсированные бициклические гетероарильные соединения и их применение в качестве ингибиторов lats
EA201992571A EA038453B1 (ru) 2018-03-29 2018-04-26 6-6-конденсированные бициклические гетероарильные соединения и их применение в качестве ингибиторов lats

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319409A1 (en) * 2010-06-23 2011-12-29 Cox Christopher D 7-aza-quinazoline pde10 inhibitors
ES2667620T3 (es) * 2011-07-15 2018-05-11 Osaka University Método para preparar una célula endotelial corneal
TWI675836B (zh) * 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑

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EA201992571A1 (ru) 2020-03-02

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