EA202190603A1 - Полипептиды анти-her2 и способы их применения - Google Patents
Полипептиды анти-her2 и способы их примененияInfo
- Publication number
- EA202190603A1 EA202190603A1 EA202190603A EA202190603A EA202190603A1 EA 202190603 A1 EA202190603 A1 EA 202190603A1 EA 202190603 A EA202190603 A EA 202190603A EA 202190603 A EA202190603 A EA 202190603A EA 202190603 A1 EA202190603 A1 EA 202190603A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- her2
- antibody
- methods
- bbb
- application
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Данное изобретение относится к конструкциям анти-HER2, таким как слитый белок димер полипептида Fc-вариабельная область антитела, которые проникают через ГЭБ и связываются с HER2 в паренхиме головного мозга. В некоторых вариантах осуществления конструкции анти-HER2 (например, слитые белки димер полипептида Fc-вариабельная область антитела) сохраняют эффекторную функцию при связывании с HER2, но не приводят к существенному истощению популяции ретикулоцитов in vivo. Данное изобретение также относится к способам трансцитоза вариабельной области антитела анти-HER2 через ГЭБ и лечения HER2-положительных онкологических заболеваний и их метастатических поражений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862721505P | 2018-08-22 | 2018-08-22 | |
PCT/US2019/047728 WO2020041604A1 (en) | 2018-08-22 | 2019-08-22 | Anti-her2 polypeptides and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202190603A1 true EA202190603A1 (ru) | 2021-07-14 |
Family
ID=67989062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202190603A EA202190603A1 (ru) | 2018-08-22 | 2019-08-22 | Полипептиды анти-her2 и способы их применения |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220002436A1 (ru) |
EP (1) | EP3840781A1 (ru) |
JP (1) | JP2021534220A (ru) |
KR (1) | KR20210074279A (ru) |
CN (1) | CN113286610A (ru) |
AR (1) | AR115998A1 (ru) |
AU (1) | AU2019326545A1 (ru) |
BR (1) | BR112021002953A2 (ru) |
CA (1) | CA3141815A1 (ru) |
EA (1) | EA202190603A1 (ru) |
IL (1) | IL280922A (ru) |
MX (1) | MX2021001976A (ru) |
SG (1) | SG11202101436SA (ru) |
TW (1) | TW202017947A (ru) |
WO (1) | WO2020041604A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA127985C2 (uk) | 2017-02-17 | 2024-03-06 | Деналі Терап'Ютікс Інк. | Сконструйований поліпептид, який зв'язує трансфериновий рецептор |
MX2020002918A (es) | 2017-10-02 | 2020-07-22 | Denali Therapeutics Inc | Proteinas de fusion que comprenden enzimas de terapia de reemplazo de enzimas. |
KR20220130678A (ko) | 2019-12-23 | 2022-09-27 | 데날리 테라퓨틱스 인크. | 프로그라눌린 변이체들 |
CA3166385A1 (en) | 2020-01-13 | 2021-07-22 | Denali Therapeutics Inc. | Anti-trem2 antibodies and methods of use thereof |
KR20230086703A (ko) | 2020-10-14 | 2023-06-15 | 데날리 테라퓨틱스 인크. | 설포글루코사민 설포하이드롤라제 효소를 포함하는 융합 단백질 및 이의 방법 |
CN118119402A (zh) * | 2021-08-25 | 2024-05-31 | 戴纳立制药公司 | 工程化抗her2双特异性蛋白 |
WO2023128702A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 아임뉴런 | 뇌혈관장벽 투과성 융합 단백질 및 이의 용도 |
KR20240067001A (ko) * | 2022-10-28 | 2024-05-16 | 주식회사 아임뉴런 | 뇌혈관장벽 투과성 융합 단백질 및 이의 용도 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3315514A1 (en) * | 2012-08-29 | 2018-05-02 | F. Hoffmann-La Roche AG | Blood brain barrier shuttle |
JP2016501881A (ja) * | 2012-12-04 | 2016-01-21 | アッヴィ・インコーポレイテッド | 血液脳関門(bbb)を透過する二重特異性結合タンパク質 |
US20160002343A1 (en) * | 2014-06-11 | 2016-01-07 | Abbvie Inc. | Blood-brain barrier (bbb) penetrating dual specific binding proteins for treating brain and neurological diseases |
WO2016207091A1 (en) * | 2015-06-24 | 2016-12-29 | F. Hoffmann-La Roche Ag | Trispecific antibodies specific for her2 and a blood brain barrier receptor and methods of use |
CN107446045A (zh) * | 2016-07-22 | 2017-12-08 | 北京天广实生物技术股份有限公司 | 一种抗her2的抗体、其药物组合物及用途 |
CA3053379A1 (en) * | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
UA127985C2 (uk) * | 2017-02-17 | 2024-03-06 | Деналі Терап'Ютікс Інк. | Сконструйований поліпептид, який зв'язує трансфериновий рецептор |
-
2019
- 2019-08-22 EP EP19769934.1A patent/EP3840781A1/en active Pending
- 2019-08-22 WO PCT/US2019/047728 patent/WO2020041604A1/en unknown
- 2019-08-22 BR BR112021002953-2A patent/BR112021002953A2/pt unknown
- 2019-08-22 TW TW108130121A patent/TW202017947A/zh unknown
- 2019-08-22 AR ARP190102390A patent/AR115998A1/es unknown
- 2019-08-22 AU AU2019326545A patent/AU2019326545A1/en active Pending
- 2019-08-22 SG SG11202101436SA patent/SG11202101436SA/en unknown
- 2019-08-22 CN CN201980068845.5A patent/CN113286610A/zh active Pending
- 2019-08-22 KR KR1020217008163A patent/KR20210074279A/ko unknown
- 2019-08-22 CA CA3141815A patent/CA3141815A1/en active Pending
- 2019-08-22 EA EA202190603A patent/EA202190603A1/ru unknown
- 2019-08-22 MX MX2021001976A patent/MX2021001976A/es unknown
- 2019-08-22 JP JP2021510094A patent/JP2021534220A/ja active Pending
-
2021
- 2021-02-16 IL IL280922A patent/IL280922A/en unknown
- 2021-02-18 US US17/178,595 patent/US20220002436A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2021534220A (ja) | 2021-12-09 |
CN113286610A (zh) | 2021-08-20 |
IL280922A (en) | 2021-04-29 |
MX2021001976A (es) | 2021-06-08 |
SG11202101436SA (en) | 2021-03-30 |
TW202017947A (zh) | 2020-05-16 |
EP3840781A1 (en) | 2021-06-30 |
CA3141815A1 (en) | 2020-02-27 |
US20220002436A1 (en) | 2022-01-06 |
AU2019326545A1 (en) | 2021-03-11 |
WO2020041604A1 (en) | 2020-02-27 |
AR115998A1 (es) | 2021-03-25 |
KR20210074279A (ko) | 2021-06-21 |
BR112021002953A2 (pt) | 2021-05-11 |
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