EA202092347A1 - Влагостойкая гранула пробиотика и способы ее получения - Google Patents

Влагостойкая гранула пробиотика и способы ее получения

Info

Publication number
EA202092347A1
EA202092347A1 EA202092347A EA202092347A EA202092347A1 EA 202092347 A1 EA202092347 A1 EA 202092347A1 EA 202092347 A EA202092347 A EA 202092347A EA 202092347 A EA202092347 A EA 202092347A EA 202092347 A1 EA202092347 A1 EA 202092347A1
Authority
EA
Eurasian Patent Office
Prior art keywords
production
methods
water resistant
edible
mediator
Prior art date
Application number
EA202092347A
Other languages
English (en)
Inventor
Адель Пенхаси
Израэль Балуашвили
Original Assignee
Поликапс Холдингз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Поликапс Холдингз Лтд. filed Critical Поликапс Холдингз Лтд.
Publication of EA202092347A1 publication Critical patent/EA202092347A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • A23V2200/3204—Probiotics, living bacteria to be ingested for action in the digestive tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Предложена пробиотическая микрокапсула, содержащая сердцевину, содержащую пробиотические микроорганизмы; и слой покрытия, содержащий гибридную твердую дисперсию, содержащую съедобную жировую молекулу, равномерно диспергированную в водорастворимом пленкообразующем полимере, и съедобный медиатор, где указанный съедобный медиатор представляет собой октенилсукцинат крахмала.
EA202092347A 2018-04-20 2019-04-20 Влагостойкая гранула пробиотика и способы ее получения EA202092347A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862660388P 2018-04-20 2018-04-20
PCT/IL2019/050454 WO2019202604A1 (en) 2018-04-20 2019-04-20 Moisture resistant probiotic granule and methods of producing the same

Publications (1)

Publication Number Publication Date
EA202092347A1 true EA202092347A1 (ru) 2021-02-17

Family

ID=68238844

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092347A EA202092347A1 (ru) 2018-04-20 2019-04-20 Влагостойкая гранула пробиотика и способы ее получения

Country Status (11)

Country Link
US (1) US20210186887A1 (ru)
EP (1) EP3781137A4 (ru)
JP (1) JP2021521249A (ru)
KR (1) KR20210003138A (ru)
CN (1) CN112292118A (ru)
AU (1) AU2019255435A1 (ru)
BR (1) BR112020021458A2 (ru)
CA (1) CA3097489A1 (ru)
EA (1) EA202092347A1 (ru)
IL (1) IL278101A (ru)
WO (1) WO2019202604A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022090474A1 (en) * 2020-10-29 2022-05-05 Deerland Probiotics & Enzymes A/S Microencapsulated microbial composition
US20240115509A1 (en) * 2021-02-11 2024-04-11 Amd Pharma Ltd A probiotic granule having a unified stabilizing coating and a method for the production thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436461B1 (en) * 1996-10-09 2002-08-20 Givauden Roure (International) Sa Process for preparing gel beads as food additives
EP1344458A1 (en) * 2002-03-12 2003-09-17 Société des Produits Nestlé S.A. Probiotic delivery system
US20050266069A1 (en) * 2002-09-06 2005-12-01 Simmons Donald L Stable probiotic microsphere compositions and their methods of preparation
CN1613455A (zh) * 2003-11-04 2005-05-11 北京东方百信生物技术有限公司 靶向益生菌微胶囊及其制备方法
CN1545936A (zh) * 2003-12-01 2004-11-17 上海交大昂立股份有限公司 一种含有活性益生菌的食用组合物及其制备方法
EP2648528B1 (en) * 2010-12-06 2016-07-20 Degama Berrier Ltd. Composition and method for improving stability and extending shelf life of probiotic bacteria and food products thereof
CN103687496A (zh) * 2011-06-07 2014-03-26 Spai集团有限公司 用于改善敏感性食品添加剂及其食品产品的稳定性并且延长其货架期的组合物和方法
US20150299516A1 (en) * 2012-11-26 2015-10-22 Progel Pty Ltd Coating composition
PT2986131T (pt) * 2013-04-19 2020-10-08 Degama Smart Ltd Grânulos com bactérias probióticas resistentes ao calor e à humidade
PL225613B1 (pl) * 2013-10-08 2017-04-28 Zachodniopomorski Univ Tech W Szczecinie Sposób wytwarzania prozdrowotnego produktu spożywczego
WO2017145143A1 (en) * 2016-02-28 2017-08-31 Degama Berrier Ltd. A film composition and methods for producing the same

Also Published As

Publication number Publication date
US20210186887A1 (en) 2021-06-24
BR112020021458A2 (pt) 2021-01-19
EP3781137A4 (en) 2022-01-05
AU2019255435A1 (en) 2020-11-26
EP3781137A1 (en) 2021-02-24
CN112292118A (zh) 2021-01-29
KR20210003138A (ko) 2021-01-11
IL278101A (en) 2020-11-30
JP2021521249A (ja) 2021-08-26
WO2019202604A1 (en) 2019-10-24
CA3097489A1 (en) 2019-10-24

Similar Documents

Publication Publication Date Title
MX2016013067A (es) Dispersion acuosa y composicion de recubrimiento que comprende la misma.
EA202092347A1 (ru) Влагостойкая гранула пробиотика и способы ее получения
SA519410903B1 (ar) خلايا التدفق ذات غطاء جل مائي
ES2720865T3 (es) Proceso de microencapsulación para la producción de microcápsulas que comprende un material inorgánico en partículas modificado en la superficie en una pared de microcápsulas entrecruzadas
MX2020004124A (es) Formulacion de fitasa.
SE1651432A1 (sv) Process for providing coating layer comprising microfibrillated cellulose
ES2530858T3 (es) Comida para mascotas, recubierta a vacío
AU2013274000A8 (en) Bioconversion processes and apparatus
MX2022012299A (es) Regulacion de la eficiencia alimenticia y la produccion de metano en animales rumiantes.
SG11201807762WA (en) Method for d2d communication, and d2d device
EP4296252A3 (en) Incorporation of biological agents in fertilizers
JP2018518943A5 (ru)
CA2901149C (en) Methods and matrices for promoting fauna and flora growth
AR102453A1 (es) Aditivo de nanocristales de celulosa o nanofibrillas de celulosa modificadas de forma química
MY187366A (en) A method of treating hair using a composition comprising an alpha-substituted aldehyde
WO2015095600A3 (en) Gypsum board with improved starch binder
EP3452084A4 (en) ANTI-KV 1.3 ANTIBODIES AND METHODS OF PRODUCING AND USING THE SAME
SA518390867B1 (ar) طرق لتوصيل ميكروبات أو إنزيمات منتجة لكربونات الكالسيوم أسفل البئر
MX2018003937A (es) Composicion acuosa de larga estabilidad a temperatura ambiente y proceso para elaborar la misma.
ZA201903637B (en) Array including sequencing primer and non-sequencing entity
WO2021216778A3 (en) Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons
AU2018279738A1 (en) Methods of enhancing development of renal organoids and methods of using the same
WO2018169309A3 (ko) 에멀젼, 에멀젼의 제조 방법 및 에멀젼을 이용한 코팅막 형성 방법
MX2021011988A (es) Microorganismo que tiene capacidad mejorada de produccion de l-treonina y procedimiento para la produccion de treonina mediante el uso del mismo.
WO2019018628A3 (en) FRAGRAMS ENCAPSULATED IN A REGULATED RELEASE POLYMER