EA202091702A1 - Биокатализатор и способы синтеза смешанных дисульфидных конъюгатов тиенопиридиновых соединений - Google Patents

Биокатализатор и способы синтеза смешанных дисульфидных конъюгатов тиенопиридиновых соединений

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Publication number
EA202091702A1
EA202091702A1 EA202091702A EA202091702A EA202091702A1 EA 202091702 A1 EA202091702 A1 EA 202091702A1 EA 202091702 A EA202091702 A EA 202091702A EA 202091702 A EA202091702 A EA 202091702A EA 202091702 A1 EA202091702 A1 EA 202091702A1
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EA
Eurasian Patent Office
Prior art keywords
synthesis
methods
conjugates
biocatalyst
thienopyridine compounds
Prior art date
Application number
EA202091702A
Other languages
English (en)
Inventor
Хаомин Чжан
Original Assignee
Зе Реджентс Оф Зе Юниверсити Оф Мичиган
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Зе Реджентс Оф Зе Юниверсити Оф Мичиган filed Critical Зе Реджентс Оф Зе Юниверсити Оф Мичиган
Publication of EA202091702A1 publication Critical patent/EA202091702A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/003—Catalysts comprising hydrides, coordination complexes or organic compounds containing enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к способам синтеза смешанных дисульфидных конъюгатов тиенопиридиновых соединений с генно-инженерным вариантом цитохрома P450 BM3 или CYP102A1 в качестве катализатора и относится к области химического синтеза.
EA202091702A 2018-01-31 2019-01-31 Биокатализатор и способы синтеза смешанных дисульфидных конъюгатов тиенопиридиновых соединений EA202091702A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862624494P 2018-01-31 2018-01-31
PCT/US2019/016099 WO2019152679A1 (en) 2018-01-31 2019-01-31 Biocatalyst and methods for synthesizing mixed disulfide conjugates of thienopyridine compounds

Publications (1)

Publication Number Publication Date
EA202091702A1 true EA202091702A1 (ru) 2021-02-24

Family

ID=67478908

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091702A EA202091702A1 (ru) 2018-01-31 2019-01-31 Биокатализатор и способы синтеза смешанных дисульфидных конъюгатов тиенопиридиновых соединений

Country Status (12)

Country Link
US (1) US20200370081A1 (ru)
EP (1) EP3746551A4 (ru)
JP (1) JP2024041908A (ru)
KR (1) KR20200115559A (ru)
CN (1) CN111699248A (ru)
AU (1) AU2019215050A1 (ru)
CA (1) CA3089861A1 (ru)
EA (1) EA202091702A1 (ru)
IL (1) IL276404A (ru)
MX (1) MX2020008073A (ru)
SG (1) SG11202007273WA (ru)
WO (1) WO2019152679A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115327004B (zh) * 2022-08-12 2024-01-26 成都施贝康生物医药科技有限公司 一种氧化氯吡格雷粗品的检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719620D0 (en) * 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
KR101048475B1 (ko) * 2008-12-03 2011-07-11 전남대학교산학협력단 박테리아 사이토크롬 피450을 이용한 피세아타놀의 신규한 생산방법 및 이를 위한 조성물
CN102863457B (zh) * 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
WO2013076258A2 (en) * 2011-11-23 2013-05-30 Dsm Ip Assets B.V. P450 bm3 mutants and their use for regio- and stereoselective hydroxylation of alpha-and beta-ionone
KR101348984B1 (ko) * 2012-01-31 2014-01-10 전남대학교산학협력단 박테리아 시토크롬 ｐ450을 이용한 오메프라졸로부터 대사산물의 신규한 생산방법 및 이를 위한 조성물
EP2906518A4 (en) * 2012-10-09 2016-07-27 California Inst Of Techn CYCLOPROPANATION OF OLEFIN IN VIVO AND IN VITRO CATALYZED BY ENZYMES HEMMES
US9718778B2 (en) * 2013-01-09 2017-08-01 The Regents Of The University Of Michigan Mixed disulfide conjugates of thienopyridine compounds and uses thereof
JP6410802B2 (ja) * 2013-09-19 2018-10-24 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 芳香性アルコールの製造方法
US20160032330A1 (en) * 2014-06-05 2016-02-04 California Institute Of Technology P-450-catalyzed enantioselective cyclopropanation of electron-deficient olefins
CN107921135A (zh) * 2015-04-30 2018-04-17 密歇根大学董事会 噻吩并吡啶化合物的混合二硫共轭物及其用法
KR101719678B1 (ko) * 2015-09-07 2017-03-24 전남대학교산학협력단 5'-하이드록시 오메프라졸 설파이드 제조용 조성물
KR101774940B1 (ko) * 2015-09-10 2017-09-20 전남대학교산학협력단 아스트린진 제조용 신규한 조성물
EP3178922B1 (en) * 2015-12-07 2019-05-22 Samsung Electronics Co., Ltd. Bacterial cytochrome p450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
CN107177541A (zh) * 2017-04-27 2017-09-19 中国农业科学院油料作物研究所 一种产羟基脂肪酸的工程菌株及其制备方法和应用
US11634400B2 (en) * 2017-08-19 2023-04-25 University Of Rochester Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents

Also Published As

Publication number Publication date
IL276404A (en) 2020-09-30
MX2020008073A (es) 2020-11-13
US20200370081A1 (en) 2020-11-26
JP2021511800A (ja) 2021-05-13
JP2024041908A (ja) 2024-03-27
KR20200115559A (ko) 2020-10-07
WO2019152679A1 (en) 2019-08-08
SG11202007273WA (en) 2020-08-28
AU2019215050A1 (en) 2020-09-03
CA3089861A1 (en) 2019-08-08
EP3746551A4 (en) 2021-11-03
EP3746551A1 (en) 2020-12-09
CN111699248A (zh) 2020-09-22

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