EA202090635A1 - Кролики с нокаутом гена фактора viii или фактора ix, способы их получения и их применение - Google Patents

Кролики с нокаутом гена фактора viii или фактора ix, способы их получения и их применение

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Publication number
EA202090635A1
EA202090635A1 EA202090635A EA202090635A EA202090635A1 EA 202090635 A1 EA202090635 A1 EA 202090635A1 EA 202090635 A EA202090635 A EA 202090635A EA 202090635 A EA202090635 A EA 202090635A EA 202090635 A1 EA202090635 A1 EA 202090635A1
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EA
Eurasian Patent Office
Prior art keywords
factor
rabbits
gene
knockout
production
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Application number
EA202090635A
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English (en)
Inventor
Со На Ким
Мён Ын Чон
Мин Чон Ким
Сон Хён Чо
Сон Хо Хван
Хи Чхон Квак
Су Мин Ли
Хён Ча Нам
Original Assignee
Грин Кросс Корпорейшн
Могам Инститьют Фор Байомедикал Рисерч
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Application filed by Грин Кросс Корпорейшн, Могам Инститьют Фор Байомедикал Рисерч filed Critical Грин Кросс Корпорейшн
Publication of EA202090635A1 publication Critical patent/EA202090635A1/ru

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/027—New or modified breeds of vertebrates
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
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    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
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    • C12N2310/10—Type of nucleic acid
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  • Peptides Or Proteins (AREA)
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Abstract

Настоящее изобретение касается кроликов с нокаутом гена фактора VIII или фактора IX, способа их получения и их применения, в частности трансгенных кроликов с нокаутом гена фактора VIII или фактора IX при помощи системы CRISPR/Cas9, способа их получения и их применения. В соответствии с настоящим изобретением у трансгенных кроликов с нокаутом гена фактора VIII и/или фактора IX ингибируется функция фактора VIII и/или фактора IX, т.е. белков, играющих важную роль в возникновении гемофилии, поэтому эти трансгенные кролики применимы для разработки способов лечения гемофилии.
EA202090635A 2017-09-28 2018-09-20 Кролики с нокаутом гена фактора viii или фактора ix, способы их получения и их применение EA202090635A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170126068 2017-09-28
PCT/KR2018/011118 WO2019066378A1 (ko) 2017-09-28 2018-09-20 Factor viii 또는 factor ix 유전자가 녹아웃된 토끼, 이의 제조방법 및 그 용도

Publications (1)

Publication Number Publication Date
EA202090635A1 true EA202090635A1 (ru) 2020-07-30

Family

ID=65901732

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090635A EA202090635A1 (ru) 2017-09-28 2018-09-20 Кролики с нокаутом гена фактора viii или фактора ix, способы их получения и их применение

Country Status (11)

Country Link
US (1) US20210161111A1 (ru)
EP (1) EP3690053A4 (ru)
JP (2) JP7091450B2 (ru)
KR (1) KR102268072B1 (ru)
CN (1) CN111492060A (ru)
AU (2) AU2018341437B2 (ru)
BR (1) BR112020006311A2 (ru)
CA (1) CA3077160A1 (ru)
EA (1) EA202090635A1 (ru)
MX (1) MX2020005732A (ru)
WO (1) WO2019066378A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021083073A1 (zh) * 2019-10-31 2021-05-06 华东师范大学 一种基于肝细胞Alb基因的疾病治疗的产品
WO2022147759A1 (en) * 2021-01-08 2022-07-14 Susheng Biotech (Hainan) Co., Ltd. Grna molecule targeting intron i or intron ii of hbb gene, synthetic method thereof, and method to correct types of hbb gene mutations
CN115943928B (zh) * 2022-12-28 2023-09-26 广州医药研究总院有限公司 可遗传的甲型血友病模型犬的建立方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016176191A1 (en) * 2015-04-27 2016-11-03 The Trustees Of The University Of Pennsylvania Dual aav vector system for crispr/cas9 mediated correction of human disease
MX2018005332A (es) * 2015-11-06 2018-11-09 Crispr Therapeutics Ag Materiales y metodos para tratamiento de la enfermedad de almacenamiento de glucogeno tipo 1a.
WO2017112895A1 (en) * 2015-12-23 2017-06-29 Haplomics, Inc. F8 gene repair
CN105567735A (zh) * 2016-01-05 2016-05-11 华东师范大学 一种凝血因子基因突变的定点修复载体系统及方法
CA3013179A1 (en) * 2016-01-30 2017-08-03 Bonac Corporation Artificial single guide rna and use thereof
WO2017141109A1 (en) * 2016-02-18 2017-08-24 Crispr Therapeutics Ag Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome

Also Published As

Publication number Publication date
KR102268072B1 (ko) 2021-06-23
JP2020536522A (ja) 2020-12-17
CA3077160A1 (en) 2019-04-04
AU2018341437A1 (en) 2020-05-07
WO2019066378A1 (ko) 2019-04-04
JP2022000055A (ja) 2022-01-04
JP7091450B2 (ja) 2022-06-27
AU2021250834A1 (en) 2021-11-04
CN111492060A (zh) 2020-08-04
EP3690053A4 (en) 2021-10-06
JP7199492B2 (ja) 2023-01-05
EP3690053A1 (en) 2020-08-05
KR20200038538A (ko) 2020-04-13
US20210161111A1 (en) 2021-06-03
BR112020006311A2 (pt) 2021-01-12
AU2018341437B2 (en) 2022-04-21
MX2020005732A (es) 2021-01-15

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