EA201992147A1 - Ингибиторы тирозинкиназы брутона - Google Patents

Ингибиторы тирозинкиназы брутона

Info

Publication number
EA201992147A1
EA201992147A1 EA201992147A EA201992147A EA201992147A1 EA 201992147 A1 EA201992147 A1 EA 201992147A1 EA 201992147 A EA201992147 A EA 201992147A EA 201992147 A EA201992147 A EA 201992147A EA 201992147 A1 EA201992147 A1 EA 201992147A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bruton
inhibitors
tyrosinkinase
tyrosinkinase inhibitors
btk
Prior art date
Application number
EA201992147A
Other languages
English (en)
Russian (ru)
Inventor
Ксибин Лиао
Джиа Ли
Джижиан Лю
Юубо Жоу
Анхуи Гао
Original Assignee
Сужоу Байджибугонг Фрамасьютикал Текнолоджи Ко.Лтд
Ксибин Лиао
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сужоу Байджибугонг Фрамасьютикал Текнолоджи Ко.Лтд, Ксибин Лиао filed Critical Сужоу Байджибугонг Фрамасьютикал Текнолоджи Ко.Лтд
Publication of EA201992147A1 publication Critical patent/EA201992147A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EA201992147A 2017-03-22 2018-03-21 Ингибиторы тирозинкиназы брутона EA201992147A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762474686P 2017-03-22 2017-03-22
PCT/US2018/023455 WO2018175512A1 (en) 2017-03-22 2018-03-21 Bruton's tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
EA201992147A1 true EA201992147A1 (ru) 2020-02-20

Family

ID=63585694

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992147A EA201992147A1 (ru) 2017-03-22 2018-03-21 Ингибиторы тирозинкиназы брутона

Country Status (12)

Country Link
US (3) US11554118B2 (OSRAM)
EP (1) EP3601264A4 (OSRAM)
JP (1) JP7219902B2 (OSRAM)
KR (1) KR102627756B1 (OSRAM)
CN (1) CN110494433B (OSRAM)
AU (1) AU2018237123B2 (OSRAM)
CA (1) CA3055602A1 (OSRAM)
EA (1) EA201992147A1 (OSRAM)
IL (1) IL269152B2 (OSRAM)
MX (1) MX2019011116A (OSRAM)
WO (1) WO2018175512A1 (OSRAM)
ZA (1) ZA201906887B (OSRAM)

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AU2020207953A1 (en) 2019-01-18 2021-08-26 Hangzhou Bangshun Pharmaceutical Co., Ltd. Bruton's tyrosine kinase inhibitors
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN111909133B (zh) * 2019-05-10 2023-07-14 河南知微生物医药有限公司 作为布鲁诺酪氨酸激酶抑制剂的取代的1-氨基-1h-咪唑-5-甲酰胺
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111471048B (zh) * 2020-04-30 2021-06-15 成都海博为药业有限公司 一种具有含氮桥环、螺环或并环结构的化合物及其用途
CN115073468B (zh) * 2021-03-15 2023-12-22 药雅科技(上海)有限公司 咪唑并吡嗪类btk抑制剂的制备及用途
CN116348453B (zh) * 2021-04-25 2025-07-04 烨辉医药科技(上海)有限公司 杂芳族甲酰胺化合物及其用途

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CA2537364A1 (en) * 2003-09-03 2005-03-10 Galapagos Nv Imidazo[1,5-a]pyridine or imidazo[1,5-a]piperidine derivatives and their use for the preparation of medicament against 5-ht2a receptor-related disorders
WO2008022060A2 (en) * 2006-08-14 2008-02-21 Novartis Ag Imidazo-pyridine derivatives for modulating protein kinase activity
DK2529622T3 (en) * 2006-09-22 2018-05-07 Pharmacyclics Llc INHIBITORS OF BRUTON-TYROSINKINASE
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EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
FR2985185B1 (fr) 2012-01-04 2013-12-27 Sanofi Sa Utilisation en therapeutique de derives d'imidazopyridine
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US20170071962A1 (en) 2015-09-11 2017-03-16 Acerta Pharma B.V. Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor
US20170035881A1 (en) * 2015-10-19 2017-02-09 Acerta Pharma B.V. Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor
EP3371189A1 (en) * 2015-11-06 2018-09-12 Acerta Pharma B.V. Imidazopyrazine inhibitors of bruton's tyrosine kinase
MX388026B (es) * 2016-03-11 2025-03-19 Angel Pharmaceutical Co Ltd Compuestos y métodos para modular la tirosina cinasa de bruton.
KR102215172B1 (ko) 2016-06-30 2021-02-16 항저우 방순 파마슈티컬 컴퍼니, 리미티드 이미다조피라진아민 페닐 유도체 및 그의 용도
WO2018033091A1 (zh) 2016-08-17 2018-02-22 深圳市塔吉瑞生物医药有限公司 用于抑制酪氨酸激酶活性的稠合双环类化合物
KR102627756B1 (ko) * 2017-03-22 2024-01-23 쑤저우 바이지부공 파마수티컬 테크널러지 컴퍼니 리미티드 브루톤 타이로신 키나제 억제제

Also Published As

Publication number Publication date
EP3601264A4 (en) 2021-03-24
US11974999B2 (en) 2024-05-07
US20210107903A1 (en) 2021-04-15
AU2018237123B2 (en) 2022-08-04
BR112019019588A2 (pt) 2020-04-22
US11554118B2 (en) 2023-01-17
ZA201906887B (en) 2022-03-30
JP2020511547A (ja) 2020-04-16
AU2018237123A1 (en) 2019-10-10
CN110494433A (zh) 2019-11-22
IL269152A (en) 2019-11-28
IL269152B2 (en) 2023-11-01
EP3601264A1 (en) 2020-02-05
IL269152B1 (en) 2023-07-01
JP7219902B2 (ja) 2023-02-09
KR20190133199A (ko) 2019-12-02
US20190275037A1 (en) 2019-09-12
WO2018175512A1 (en) 2018-09-27
CA3055602A1 (en) 2018-09-27
US10933063B2 (en) 2021-03-02
MX2019011116A (es) 2020-02-05
CN110494433B (zh) 2023-03-17
KR102627756B1 (ko) 2024-01-23
US20210121458A1 (en) 2021-04-29

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