EA201892327A1 - Ингаляционные и назальные бензодиазепины - Google Patents

Ингаляционные и назальные бензодиазепины

Info

Publication number
EA201892327A1
EA201892327A1 EA201892327A EA201892327A EA201892327A1 EA 201892327 A1 EA201892327 A1 EA 201892327A1 EA 201892327 A EA201892327 A EA 201892327A EA 201892327 A EA201892327 A EA 201892327A EA 201892327 A1 EA201892327 A1 EA 201892327A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzodiazepina
nazal
inhalation
remiamazolam
oindp
Prior art date
Application number
EA201892327A
Other languages
English (en)
Other versions
EA036520B1 (ru
Inventor
Карл-Уве Петерсен
Дерек Джо Саката
Томас Штер
Джон Грэхем
Бретт Купер
Татьяна Беванз
Кристофер Рейлли
Original Assignee
ПАЙОН ЮКей ЛИМИТЕД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ПАЙОН ЮКей ЛИМИТЕД filed Critical ПАЙОН ЮКей ЛИМИТЕД
Publication of EA201892327A1 publication Critical patent/EA201892327A1/ru
Publication of EA036520B1 publication Critical patent/EA036520B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Настоящее изобретение относится к ингаляционному и назальному лекарственному продукту (OINDP), содержащему бензодиазепин, в частности ремимазолам.
EA201892327A 2016-04-14 2017-04-18 Ингаляционные и назальные бензодиазепины EA036520B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU93027 2016-04-14
PCT/EP2017/059214 WO2017178663A1 (en) 2016-04-14 2017-04-18 Orally inhaled and nasal benzodiazepines

Publications (2)

Publication Number Publication Date
EA201892327A1 true EA201892327A1 (ru) 2019-04-30
EA036520B1 EA036520B1 (ru) 2020-11-19

Family

ID=55949007

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892327A EA036520B1 (ru) 2016-04-14 2017-04-18 Ингаляционные и назальные бензодиазепины

Country Status (12)

Country Link
US (3) US20190175613A1 (ru)
EP (1) EP3442539A1 (ru)
JP (2) JP2019513796A (ru)
KR (1) KR20180131617A (ru)
CN (1) CN109641000A (ru)
AU (1) AU2017248683A1 (ru)
BR (1) BR112018071082A2 (ru)
CA (1) CA3020722A1 (ru)
EA (1) EA036520B1 (ru)
IL (1) IL262087B (ru)
MX (1) MX2018012498A (ru)
WO (1) WO2017178663A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111346098B (zh) * 2018-12-21 2022-05-27 宜昌人福药业有限责任公司 苯二氮䓬类化合物局部用药物组合物及制备方法和用途
CN111346058B (zh) * 2018-12-21 2022-05-17 宜昌人福药业有限责任公司 一种苯二氮䓬类化合物经鼻粘膜给药的药物组合物及其制备方法和用途
CN111346065B (zh) * 2018-12-21 2022-05-20 宜昌人福药业有限责任公司 苯二氮䓬类化合物口腔用固体药物组合物及其制备方法
EP3714884A1 (en) 2019-03-27 2020-09-30 Paion UK Limited Medical uses for benzodiazepines with a particular eeg pattern
CN112209932B (zh) * 2019-07-12 2023-03-24 成都倍特药业股份有限公司 一种化合物氢溴酸盐的新固体形态及其制备方法和用途
CN112462015B (zh) * 2020-11-18 2022-07-12 海南倍特药业有限公司 一种氢溴酸瑞马唑仑细菌内毒素的检测方法
CN112402428B (zh) * 2020-11-26 2022-02-25 李依泽 瑞马唑仑在制备治疗阿片类药物诱发的术后痛觉过敏的药物中的应用
CN114588164B (zh) * 2022-04-19 2023-08-11 天津医科大学总医院 瑞马唑仑在预防围术期低体温和寒战中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4950664A (en) * 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
CN1168140A (zh) 1995-01-06 1997-12-17 弗·哈夫曼-拉罗切有限公司 羟甲基咪唑并二氮杂䓬及其酯
WO1996023790A1 (de) 1995-02-02 1996-08-08 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepine
GB9911152D0 (en) 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
GB0613692D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
ATE480532T1 (de) 2006-07-10 2010-09-15 Paion Uk Ltd Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
GB0716907D0 (en) * 2007-08-31 2007-10-10 Archimedes Dev Ltd Pharmaceutical powder compositions
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) * 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
WO2012075286A2 (en) * 2010-12-01 2012-06-07 The Regents Of The University Of California Intrapulmonary benzodiazepine for the treatment and prevention of seizures
WO2012135536A1 (en) * 2011-04-01 2012-10-04 Cpex Pharmaceuticals, Inc. Nasal formulations of benzodiazepine
CN102964349A (zh) 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
WO2013174883A1 (en) * 2012-05-22 2013-11-28 Paion Uk Limited Compositions comprising short-acting benzodiazepines
SG11201501358SA (en) * 2012-08-31 2015-04-29 Paion Uk Ltd Method for administering hypnotic/sedative agent
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN103232454A (zh) * 2013-05-05 2013-08-07 王元青 治疗精神疾病的药物
CN107198691A (zh) * 2016-03-17 2017-09-26 江苏恒瑞医药股份有限公司 一种瑞马唑仑的药物组合物

Also Published As

Publication number Publication date
AU2017248683A1 (en) 2018-10-25
US20190175613A1 (en) 2019-06-13
IL262087B (en) 2021-09-30
MX2018012498A (es) 2019-07-01
CN109641000A (zh) 2019-04-16
US20200253983A1 (en) 2020-08-13
KR20180131617A (ko) 2018-12-10
JP2019513796A (ja) 2019-05-30
EP3442539A1 (en) 2019-02-20
JP2021185170A (ja) 2021-12-09
US20220273672A1 (en) 2022-09-01
EA036520B1 (ru) 2020-11-19
WO2017178663A1 (en) 2017-10-19
BR112018071082A2 (pt) 2019-02-05
IL262087A (en) 2018-11-29
CA3020722A1 (en) 2017-10-19

Similar Documents

Publication Publication Date Title
EA201892327A1 (ru) Ингаляционные и назальные бензодиазепины
MX2022001755A (es) Compuestos de dinucleotidos ciclicos y metodos de uso.
HK1246103A1 (zh) 非燃燒型香味抽吸器、香吸味源單元及霧化單元
MX2020009649A (es) Anticuerpos monoclonales contra bcma.
BR112018012145A2 (pt) partículas de entrega de pró-sabor
EA201891791A1 (ru) Надежно прикрепляющиеся картриджи для испарительных устройств
MX2017004838A (es) Composiciones de interleucina-15 y usos de estas.
MY187540A (en) Compounds active towards bromodomains
EA202091615A1 (ru) Интраназальные составы на основе эпинефрина и способы лечения заболевания
UA116648C2 (uk) Фумарати як проліки та їх застосування при лікуванні різних захворювань
MY184586A (en) Adenoassociated virus vectors for the treatment of mucopolysaccharidoses
PH12016502248A1 (en) Adenoassociated virus vectors for the treatment of lysosomal storage disorders
MX2017004219A (es) Uso de carbaldehidos ciclicos novedosos como una sustancia aromatica.
EA201790575A1 (ru) Триазолопиразиноны в качестве ингибиторов pde1
PH12016501873A1 (en) Anti-influenza b virus hemagglutinin antibodies and methods of use
MX2018007304A (es) Composiciones de interleucina-15 y sus usos.
EA201792157A1 (ru) Имидазопиразиноны в качестве ингибиторов pde1
EA202090683A3 (ru) Способы и композиции для лечения рака
PH12019501018A1 (en) Pharmaceutical composition, methods for treating and uses thereof
TR201910866T4 (tr) Kanser tedavisi için birleşik preparasyonlar.
MX2017002239A (es) Composicion que contiene cineol para la administracion nasal.
MX2017012596A (es) Una composicion farmaceutica y el uso de la misma.
CO2017001601A2 (es) Derivados de 1-acetil-4-((pirazin-2-il) amino)-1,2,3,4-tetrahydroquinolina-6 carboxamida como inhibidores de bromodominio
EA201792571A1 (ru) Терапевтическое применение l-4-хлорокинуренина
SG10201805646WA (en) Angiopoietin-like 4 antibodies and methods of use