EA201892156A1 - Система доставки - Google Patents

Система доставки

Info

Publication number
EA201892156A1
EA201892156A1 EA201892156A EA201892156A EA201892156A1 EA 201892156 A1 EA201892156 A1 EA 201892156A1 EA 201892156 A EA201892156 A EA 201892156A EA 201892156 A EA201892156 A EA 201892156A EA 201892156 A1 EA201892156 A1 EA 201892156A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oil
proposed
methods
organic solvent
dosage form
Prior art date
Application number
EA201892156A
Other languages
English (en)
Inventor
Томас Хнат
Original Assignee
Смартек Топикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смартек Топикал, Инк. filed Critical Смартек Топикал, Инк.
Publication of EA201892156A1 publication Critical patent/EA201892156A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В соответствии с настоящим описанием предложены лекарственные формы, содержащие: (a) по меньшей мере один активный агент; (b) масло и необязательно загуститель для него; (c) органический растворитель и загуститель для него и (d) усилитель проникновения через кожу, растворимый в масле и/или растворителе; где указанная лекарственная форма содержит <10 мас.% воды; и указанная лекарственная форма необязательно образует тиксотропный разжижаемый гель. Также предложены гели, содержащие масло и органический растворитель, способы их получения и способы местной доставки активного агента субъекту, нуждающемуся в этом.
EA201892156A 2016-03-31 2017-03-31 Система доставки EA201892156A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662316064P 2016-03-31 2016-03-31
PCT/US2017/025373 WO2017173269A1 (en) 2016-03-31 2017-03-31 Delivery system

Publications (1)

Publication Number Publication Date
EA201892156A1 true EA201892156A1 (ru) 2019-03-29

Family

ID=59965231

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892156A EA201892156A1 (ru) 2016-03-31 2017-03-31 Система доставки

Country Status (13)

Country Link
US (2) US11666531B2 (ru)
EP (1) EP3435978A4 (ru)
JP (1) JP2019510824A (ru)
KR (1) KR20190003535A (ru)
CN (1) CN109414405A (ru)
AU (1) AU2017240680A1 (ru)
BR (1) BR112018070140A2 (ru)
CA (1) CA3019582A1 (ru)
EA (1) EA201892156A1 (ru)
MX (1) MX2018011881A (ru)
PH (1) PH12018502036A1 (ru)
SG (1) SG11201808231VA (ru)
WO (1) WO2017173269A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018001429B1 (pt) 2015-08-13 2022-11-22 Basf Se Composição líquida não aquosa, método para a preparação da composição e método não terapêutico para controlar fungos fitopatogênicos e/ ou crescimento indesejado de plantas e/ ou ataque indesejado por insetos ou ácaros e/ ou para regular o crescimento de plantas
DE102016107563A1 (de) * 2016-04-22 2017-10-26 Sven Reichwagen Vitaminzubereitung
WO2020223093A1 (en) 2019-04-30 2020-11-05 Bayer Healthcare Llc Topical analgesic gel compositions
US11839593B2 (en) 2019-05-28 2023-12-12 Tech Swerve Llc Penetrating topical pain relief compositions and methods of use
EP3975703A4 (en) * 2019-05-28 2023-07-12 Tech Swerve LLC PENETRATING TOPICAL PAIN RELIEF COMPOSITIONS AND METHODS OF USE
CN114302707A (zh) 2019-06-14 2022-04-08 普洛拉治疗公司 局部阿昔洛韦制剂及其用途
US11026896B2 (en) * 2019-06-18 2021-06-08 Dyve Biosciences, Inc. Transdermal penetrant formulations containing cannabidiol
BR112022000767A2 (pt) 2019-07-16 2022-03-15 Donaghys Ltd Sistema de solvente transdérmico e métodos de uso
US20220378729A1 (en) * 2019-11-06 2022-12-01 Smartech Topical, Inc. Topical formulations of cyclooxygenase inhibitors and their use
CA3160323A1 (en) * 2019-11-07 2021-05-14 Amyris, Inc. Compositions and methods for delivering cannabinoids to skin
US11213467B2 (en) * 2019-11-07 2022-01-04 Amyris, Inc. Compositions and methods for delivering cannabinoids to skin
CN110917053A (zh) * 2019-12-06 2020-03-27 辉达生物医药（苏州）有限公司 一种抗炎组合物
CN113827547A (zh) * 2020-06-23 2021-12-24 南京清普生物科技有限公司 一种缓释制剂组合物
WO2022217147A1 (en) * 2021-04-09 2022-10-13 Rosenfeld Mark J Methods for improving cutaneous permeation of cannabinoids and fatty acid amides
US20240139133A1 (en) * 2021-05-05 2024-05-02 Smartech Topical, Inc. Topical naproxen formulations and their use

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63225312A (ja) * 1986-10-02 1988-09-20 Kao Corp 透明ないし半透明のジエリー状の化粧料
US5002938A (en) * 1988-03-21 1991-03-26 Bristol-Myers Squibb Company Antifungal gel formulations
US8980290B2 (en) * 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7618651B2 (en) 2004-06-24 2009-11-17 Idexx Laboratories Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
JP2006265153A (ja) * 2005-03-23 2006-10-05 Noevir Co Ltd ゲル組成物
EP1909772A4 (en) * 2005-08-05 2011-07-13 Nuvo Res Inc TRANSDERMAL DRUG FORMULATION
MX2009004038A (es) * 2006-10-17 2009-08-24 Nuvo Res Gel de diclofenaco.
UA97529C2 (ru) 2007-06-08 2012-02-27 Троикаа Фармасьютикалс Лтд. Новый безводный раствор диклофенака местного применения и процесс его приготовления
JP6076597B2 (ja) * 2008-08-09 2017-02-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 化粧品としてのインドール化合物の使用
BR112012011336A2 (pt) * 2009-10-22 2018-10-16 Api Genesis Llc Composições compreendendo flavonoides, seu método de preparação, adesivo para aplicação de flavonoide, métodos de produção de flavonoide hidratado,métodos de preparação de formulação tópica, e uso de flavonoide
AU2009356171B2 (en) * 2009-12-04 2013-03-21 Colgate-Palmolive Company Dissolvable films containing high concentrations of nonionic surfactants such as polysorbates to enhance high solid loadings
CA2792018A1 (en) * 2010-05-10 2011-11-17 Segetis, Inc. Fragrant formulations, methods of manufacture thereof and articles comprising the same
US9504664B2 (en) * 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
WO2012151427A1 (en) * 2011-05-03 2012-11-08 Aponia Laboratories, Inc. Transdermal compositions of ibuprofen and methods of use thereof
WO2013088380A1 (en) * 2011-12-12 2013-06-20 Leo Laboratories Limited Gel compositions
CN102652730B (zh) * 2012-03-29 2014-04-16 武汉华大药业有限公司 软膏基质、苦参绿茶软膏及其制备方法
US8822537B2 (en) * 2012-09-27 2014-09-02 Achelios Therapeutics, Inc. Topical ketoprofen composition
US20150313825A1 (en) * 2012-11-21 2015-11-05 Topokine Therapeutics, Inc. Methods and compositions for locally increasing body fat
CN113712911A (zh) * 2013-03-15 2021-11-30 维普詹尼克斯公司 新型镇痛组合物
US9012402B1 (en) * 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation

Also Published As

Publication number Publication date
AU2017240680A1 (en) 2018-11-15
WO2017173269A1 (en) 2017-10-05
EP3435978A1 (en) 2019-02-06
BR112018070140A2 (pt) 2019-02-05
MX2018011881A (es) 2018-12-17
EP3435978A4 (en) 2019-12-11
PH12018502036A1 (en) 2019-07-15
SG11201808231VA (en) 2018-10-30
US20190046438A1 (en) 2019-02-14
US11666531B2 (en) 2023-06-06
CA3019582A1 (en) 2017-10-05
CN109414405A (zh) 2019-03-01
KR20190003535A (ko) 2019-01-09
JP2019510824A (ja) 2019-04-18
US20230310318A1 (en) 2023-10-05

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