EA201891571A1 - Геномное профилирование отдельных циркулирующих опухолевых клеток (ctc) при метастазирующем заболевании для характеризации гетерогенности заболевания - Google Patents

Геномное профилирование отдельных циркулирующих опухолевых клеток (ctc) при метастазирующем заболевании для характеризации гетерогенности заболевания

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Publication number
EA201891571A1
EA201891571A1 EA201891571A EA201891571A EA201891571A1 EA 201891571 A1 EA201891571 A1 EA 201891571A1 EA 201891571 A EA201891571 A EA 201891571A EA 201891571 A EA201891571 A EA 201891571A EA 201891571 A1 EA201891571 A1 EA 201891571A1
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EA
Eurasian Patent Office
Prior art keywords
disease
ctc
heterogeneity
tumor cells
circulating tumor
Prior art date
Application number
EA201891571A
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English (en)
Russian (ru)
Inventor
Райан Диттамор
Дена Марринуччи
Original Assignee
Эпик Сайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Эпик Сайенсиз, Инк. filed Critical Эпик Сайенсиз, Инк.
Publication of EA201891571A1 publication Critical patent/EA201891571A1/ru

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EA201891571A 2016-01-06 2017-01-05 Геномное профилирование отдельных циркулирующих опухолевых клеток (ctc) при метастазирующем заболевании для характеризации гетерогенности заболевания EA201891571A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662275659P 2016-01-06 2016-01-06
US201662344703P 2016-06-02 2016-06-02
PCT/US2017/012317 WO2017120324A1 (en) 2016-01-06 2017-01-05 Single cell genomic profiling of circulating tumor cells (ctcs) in metastatic disease to characterize disease heterogeneity

Publications (1)

Publication Number Publication Date
EA201891571A1 true EA201891571A1 (ru) 2019-01-31

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EA201891571A EA201891571A1 (ru) 2016-01-06 2017-01-05 Геномное профилирование отдельных циркулирующих опухолевых клеток (ctc) при метастазирующем заболевании для характеризации гетерогенности заболевания

Country Status (8)

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US (2) US20190025312A1 (enExample)
EP (1) EP3400311A4 (enExample)
JP (3) JP2019502384A (enExample)
CN (2) CN115323054A (enExample)
AU (2) AU2017205443A1 (enExample)
CA (1) CA3010311A1 (enExample)
EA (1) EA201891571A1 (enExample)
WO (1) WO2017120324A1 (enExample)

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EP2491395B1 (en) 2009-10-21 2015-09-16 The Scripps Research Institute Method of using non-rare cells to detect rare cells
WO2015112955A1 (en) 2014-01-27 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for prostate cancer biomarkers
EA201691682A1 (ru) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. Способы анализирования редких циркулирующих в крови клеток
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
US11222194B2 (en) * 2016-12-30 2022-01-11 Ventana Medical Systems, Inc. Automated system and method for creating and executing a scoring guide to assist in the analysis of tissue specimen
EP3431611A1 (en) 2017-07-21 2019-01-23 Menarini Silicon Biosystems S.p.A. Improved method and kit for the generation of dna libraries for massively parallel sequencing
US11348661B2 (en) 2018-05-14 2022-05-31 Tempus Labs, Inc. Predicting total nucleic acid yield and dissection boundaries for histology slides
US10957041B2 (en) 2018-05-14 2021-03-23 Tempus Labs, Inc. Determining biomarkers from histopathology slide images
CN109060989B (zh) * 2018-08-29 2021-07-30 重庆市肿瘤研究所 应用iTRAQ技术研究三阴性乳腺癌外泌体差异表达蛋白的方法
CN109658981B (zh) * 2018-12-10 2022-10-04 海南大学 一种单细胞测序的数据分类方法
EP3991171B1 (en) * 2019-03-26 2025-07-09 Tempus AI, Inc. Determining biomarkers from histopathology slide images
KR102343947B1 (ko) * 2019-09-30 2021-12-27 주식회사 피디젠 환자 정보 분석을 이용한 암 재발 및 전이 모니터링 시스템을 이용한 비즈니스모델
EP3965119A1 (en) * 2020-09-04 2022-03-09 Koninklijke Philips N.V. Methods for estimating heterogeneity of a tumour based on values for two or more genome mutation and/or gene expression related parameter, as well as corresponding devices
CN112164420B (zh) * 2020-09-07 2021-07-20 厦门艾德生物医药科技股份有限公司 一种基因组瘢痕模型的建立方法
WO2022225995A1 (en) * 2021-04-19 2022-10-27 F. Hoffmann-La Roche Ag Methods and systems for gene alteration prediction from pathology slide images
WO2023107566A1 (en) * 2021-12-07 2023-06-15 Epic Sciences, Inc. Enhanced characterization of breast cancer
JP2025505920A (ja) * 2021-12-21 2025-03-05 ファウンデーション・メディシン・インコーポレイテッド ゲノムプロファイリングの成功を予測するための方法及びシステム

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JP5457673B2 (ja) * 2005-09-20 2014-04-02 ベリデックス・リミテッド・ライアビリティ・カンパニー ユニーク配列のｄｎａプローブを作製するための方法および組成物、ｄｎａプローブの標識、ならびにこれらプローブの使用
DK2981624T3 (da) * 2013-04-05 2020-03-02 Myriad Genetics Inc Fremgangsmåder til vurdering af homolog rekombinationsdeficiens og forudsigelse af respons på cancerbehandling
CN106062561B (zh) * 2013-09-30 2021-11-09 斯克利普斯研究院 为了监测前列腺癌患者中的肿瘤进化进行循环肿瘤细胞的基因型和表型分析
US10745760B2 (en) * 2014-01-17 2020-08-18 University Health Network Biopsy-driven genomic signature for prostate cancer prognosis
US20160011198A1 (en) * 2014-01-27 2016-01-14 Epic Sciences, Inc. Detection of prostate specific membrane antigen (psma) expression on circulating tumor cells (ctc)
WO2015112955A1 (en) * 2014-01-27 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for prostate cancer biomarkers
EP3100052B1 (en) * 2014-01-30 2021-03-10 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies

Also Published As

Publication number Publication date
JP2021118689A (ja) 2021-08-12
US20190025312A1 (en) 2019-01-24
CN108884494A (zh) 2018-11-23
AU2023202282A1 (en) 2023-05-11
EP3400311A1 (en) 2018-11-14
JP2019502384A (ja) 2019-01-31
US20220390451A1 (en) 2022-12-08
CA3010311A1 (en) 2017-07-13
WO2017120324A1 (en) 2017-07-13
EP3400311A4 (en) 2019-07-03
JP2023116530A (ja) 2023-08-22
AU2017205443A1 (en) 2018-07-19
CN115323054A (zh) 2022-11-11

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