EA201891396A1 - Способ получения 2-[4-(4-хлорфенокси)-2-(трифторметил)фенил]-1-(1,2,4-триазол-1-ил)пропан-2-ола - Google Patents

Способ получения 2-[4-(4-хлорфенокси)-2-(трифторметил)фенил]-1-(1,2,4-триазол-1-ил)пропан-2-ола

Info

Publication number
EA201891396A1
EA201891396A1 EA201891396A EA201891396A EA201891396A1 EA 201891396 A1 EA201891396 A1 EA 201891396A1 EA 201891396 A EA201891396 A EA 201891396A EA 201891396 A EA201891396 A EA 201891396A EA 201891396 A1 EA201891396 A1 EA 201891396A1
Authority
EA
Eurasian Patent Office
Prior art keywords
chlorophenoxy
trifluoromethyl
phenyl
producing
ola
Prior art date
Application number
EA201891396A
Other languages
English (en)
Other versions
EA036139B1 (ru
Inventor
Йоахим Гебхардт
Даниэль Зелингер
Манфред Эресманн
Роланд Гётц
Original Assignee
Басф Агро Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Басф Агро Б.В. filed Critical Басф Агро Б.В.
Publication of EA201891396A1 publication Critical patent/EA201891396A1/ru
Publication of EA036139B1 publication Critical patent/EA036139B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к способу получения 2-[4-(4-хлорфенокси)-2-(трифторметил)фенил]-1-(1,2,4-триазол-1-ил)пропан-2-ола с высокой чистотой. В особенности, оно относится к способу, в котором это соединение эффективно отделяют от его изомера 1,2,4-триазол-4-ила.
EA201891396A 2015-12-18 2016-12-15 Способ получения 2-[4-(4-хлорфенокси)-2-(трифторметил)фенил]-1-(1,2,4-триазол-1-ил)пропан-2-ола EA036139B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15201269 2015-12-18
PCT/EP2016/081113 WO2017102905A1 (en) 2015-12-18 2016-12-15 Method for producing 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

Publications (2)

Publication Number Publication Date
EA201891396A1 true EA201891396A1 (ru) 2019-01-31
EA036139B1 EA036139B1 (ru) 2020-10-02

Family

ID=54850432

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891396A EA036139B1 (ru) 2015-12-18 2016-12-15 Способ получения 2-[4-(4-хлорфенокси)-2-(трифторметил)фенил]-1-(1,2,4-триазол-1-ил)пропан-2-ола

Country Status (13)

Country Link
US (1) US11168060B2 (ru)
EP (1) EP3390371B1 (ru)
KR (1) KR102642072B1 (ru)
CN (1) CN108602781A (ru)
BR (1) BR112018010988B1 (ru)
CA (1) CA3006946C (ru)
EA (1) EA036139B1 (ru)
HU (1) HUE047666T2 (ru)
IL (1) IL259609B (ru)
MX (1) MX2018007513A (ru)
PL (1) PL3390371T3 (ru)
UA (1) UA123732C2 (ru)
WO (1) WO2017102905A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10538470B2 (en) 2015-05-08 2020-01-21 BASF Agro B.V. Process for the preparation of limonene-4-ol
CN107635982A (zh) 2015-05-08 2018-01-26 巴斯夫农业公司 制备萜品油烯环氧化物的方法
BR112018076043B1 (pt) 2016-06-15 2023-09-26 Basf Agro B.V Processo de epoxidação de alqueno tetrassubstituído e uso de agente oxidante
WO2017215929A1 (en) 2016-06-15 2017-12-21 BASF Agro B.V. Process for the epoxidation of a tetrasubstituted alkene
AU2017353264B2 (en) 2016-11-04 2021-08-05 Basf Se Process for purification of pyrazolpyridazines
US10538493B2 (en) 2016-11-17 2020-01-21 Basf Se Process for the purification of 1-(4-chlorophenyl)pyrazol-3-ol
CN110431126B (zh) 2017-03-20 2022-12-02 巴斯夫欧洲公司 制备一溴三氯甲烷的方法
CN110740995B (zh) 2017-06-14 2023-07-14 巴斯夫农业公司 制备取代苯氧基苯基醇的方法
EP3704086B1 (en) 2017-11-02 2024-02-21 Basf Se Process for preparing 4-chlorobenzyl propargyl ether
EP3666759A1 (en) 2018-12-10 2020-06-17 Bayer Aktiengesellschaft Preparation of 6-halo-2-(haloalkyl)-3-acylpyridines and intermediates therefor
US11272707B2 (en) 2019-05-31 2022-03-15 Sumitomo Chemical Company, Limited Liquid composition comprising mefentrifluconazole
US11033030B2 (en) 2019-05-31 2021-06-15 Sumitomo Chemical Company, Limited Liquid composition comprising mefentrifluconazole
BR112021023964A2 (pt) * 2019-05-31 2022-02-01 Sumitomo Chemical Co Formulação concentrada de suspensão líquida compreendendo mefentrifluconazol
US11317629B2 (en) 2019-05-31 2022-05-03 Sumitomo Chemical Company, Limited Liquid composition comprising mefentrifluconazole
WO2023247239A1 (en) 2022-06-20 2023-12-28 BASF Agro B.V. Method for producing 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE547409T1 (de) 2007-11-28 2012-03-15 Fresenius Kabi Oncology Ltd Verbessertes verfahren zur herstellung von letrozol und zwischenprodukten davon
MY163323A (en) 2011-07-13 2017-09-15 Basf Agro Bv Fungicidal substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds
CN107488154B (zh) 2013-01-09 2021-04-27 巴斯夫农业公司 制备取代环氧乙烷类和三唑类的方法
US10093634B2 (en) 2013-12-18 2018-10-09 BASF Agro B.V. Process for the preparation of substituted phenoxyphenyl ketones
CN106660979B (zh) 2014-07-08 2020-07-07 巴斯夫农业公司 制备取代的环氧乙烷类和三唑类的方法
US10118882B2 (en) 2015-06-17 2018-11-06 BASF Agro B.V. Process for the preparation of substituted phenyl ketones

Also Published As

Publication number Publication date
WO2017102905A1 (en) 2017-06-22
UA123732C2 (uk) 2021-05-26
US20210214319A1 (en) 2021-07-15
EA036139B1 (ru) 2020-10-02
CA3006946C (en) 2024-04-16
CN108602781A (zh) 2018-09-28
IL259609B (en) 2021-03-25
MX2018007513A (es) 2018-11-29
IL259609A (en) 2018-07-31
HUE047666T2 (hu) 2020-05-28
PL3390371T3 (pl) 2020-05-18
EP3390371A1 (en) 2018-10-24
BR112018010988B1 (pt) 2022-01-18
CA3006946A1 (en) 2017-06-22
KR102642072B1 (ko) 2024-02-28
US11168060B2 (en) 2021-11-09
EP3390371B1 (en) 2019-11-20
KR20180094983A (ko) 2018-08-24
BR112018010988A2 (pt) 2018-12-04

Similar Documents

Publication Publication Date Title
EA201891396A1 (ru) Способ получения 2-[4-(4-хлорфенокси)-2-(трифторметил)фенил]-1-(1,2,4-триазол-1-ил)пропан-2-ола
UA122520C2 (uk) Кристалічна форма 2-[4-(4-хлорфенокси)-2-(трифторметил)феніл]-1-(1,2,4-триазол-1-іл)пропан-2-олу, агрохімічна композиція, застосування та спосіб боротьби зі шкідливими грибами
EA201890373A1 (ru) Пиридиновые соединения, пригодные для борьбы с фитопатогенными грибами
CO2017002714A2 (es) Ácido 4-(3-fluoro-3-(2-(5,6,7,8-tetrahidro-1,8-naftiridin-2-il)etil)pirrolidin-1-il)-3-(3-(2-metoxietoxi)fenil)butanoico, o una sal del mismo
CL2014000125A1 (es) Compuesto fungicidas de 1-(2-(2-halo-4-(4-halogen-fenoxi)-fenil)-2-etoxi-etil)-1h-(1,2,4)triazol sustituidos; procesos para preparar dichos compuestos; uso de dichos compuestos para combatir hongos fitopatógenos.
CL2014000202A1 (es) Compuestos fungicidas de 1-(2-(2-halo-4-(4-halogen-fenoxi)-fenil)-2-alcoxi-3-metil-butil)-1h(1,2,4)triazol sustituidos; proceso para preparar dicho compuesto; uso de dichos compuestos para combatir hongos fitopatogenos.
CL2014000201A1 (es) Compuestos fungicidas de 1-(2-(2-halo-4-(4-halogen-fenoxi)-fenil)-2-aluiniloxi-etil)-1h-(1,2,4)triazol sustituidos; procesos para preparar dichos compuestos; uso de dichos compuestos para combatir hongos fitopatógenos.
CL2014000384A1 (es) Compuestos fungicidas de 1-(2-(2-halo-4-(4-halogen-fenoxi)-fenil)-2-alcoxi-2-alquinil/alquenil-etil)-1h-(1,2,4) triazol sustituidos; proceso para preparar dichos compuestos; composiciones agroquímicas.
AR106728A1 (es) 4-((6-(2-(2,4difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación
CL2016003145A1 (es) Compuestos de [1,2,4]triazol sustituido
EA201691913A1 (ru) Замещенные [1,2,4]триазольные и имидазольные соединения в качестве фунгицидов
EA202091505A1 (ru) Триазолазолы циклогексильной кислоты в качестве антагонистов lpa
CO2017001608A2 (es) Compuestos fusionados de 11 miembros y fungicidas agrícolas/hortícolas que los contienen
AR106730A1 (es) 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación
EA201892682A1 (ru) Пестицидные композиции
EA201891042A1 (ru) Тризамещенные силилфеноксигетероциклы и аналоги
MX2018001731A (es) Un proceso novedoso para preparar n-[2-[[[1-(4-clorofenil)-1h-pira zol-3-il]oxi]metil]fenil]-n-metoxicarbamato de metilo cristalino.
CY1122506T1 (el) Κρυσταλλικη μορφη της ενωσης (s)-3-{4-[5-(2-κυκλοπεντυλ-6- μεθοξυ- πυριδιν-4- υλ)-[1,2,4]οξαδιαζολ-3- υλ]-2- αιθυλ-6-μεθυλ- φαινοξυ}- προπανο-1,2- διολη
CL2017000484A1 (es) Compuestos de azetidiniloxifenilpirrolidina
EA201892235A1 (ru) Гранулированная композиция для перорального применения
EA201691999A1 (ru) Новые сульфониламинобензамидные соединения
MX2019004024A (es) Metodo para preparar acetofenonas sustituidas con ciclopropilo.
ITMI20110647A1 (it) Procedimento migliorato per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib.
EP3233824A4 (en) (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations
EA201692246A1 (ru) Способ получения 2,6-диметилбензохинона

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM