EA201791113A1 - Фармацевтические составы в виде гранул, содержащие диметилфумарат - Google Patents
Фармацевтические составы в виде гранул, содержащие диметилфумаратInfo
- Publication number
- EA201791113A1 EA201791113A1 EA201791113A EA201791113A EA201791113A1 EA 201791113 A1 EA201791113 A1 EA 201791113A1 EA 201791113 A EA201791113 A EA 201791113A EA 201791113 A EA201791113 A EA 201791113A EA 201791113 A1 EA201791113 A1 EA 201791113A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical compositions
- core
- granules containing
- dimethyl fumarate
- layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Abstract
Изобретение обеспечивает новые фармацевтические композиции диметилфумарата. Фармацевтические композиции по настоящему изобретению находятся в форме гранулы и содержат (i) инертное ядро; (ii) первый слой, окружающий инертное ядро, при этом первый слой содержит диметилфумарат; и (iii) кишечно-растворимую оболочку, окружающую первый слой. Также обеспечиваются фармацевтические композиции в форме гранулы, содержащей ядро и кишечно-растворимую оболочку, окружающую ядро, при этом ядро содержит диметилфумарат. Также включены способы применения фармацевтических композиций по настоящему изобретению для лечения рассеянного склероза.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462081889P | 2014-11-19 | 2014-11-19 | |
PCT/US2015/061456 WO2016081676A1 (en) | 2014-11-19 | 2015-11-19 | Pharmaceutical bead formulations comprising dimethyl fumarate |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201791113A1 true EA201791113A1 (ru) | 2017-10-31 |
EA039157B1 EA039157B1 (ru) | 2021-12-13 |
Family
ID=54705913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791113A EA039157B1 (ru) | 2014-11-19 | 2015-11-19 | Фармацевтические составы в виде гранул, содержащие диметилфумарат |
Country Status (13)
Country | Link |
---|---|
US (1) | US11197842B2 (ru) |
EP (1) | EP3220898A1 (ru) |
JP (2) | JP6843748B2 (ru) |
KR (1) | KR20170086063A (ru) |
CN (2) | CN113521029A (ru) |
AU (1) | AU2015349896B2 (ru) |
CA (1) | CA2967647A1 (ru) |
EA (1) | EA039157B1 (ru) |
HK (1) | HK1244214A1 (ru) |
IL (1) | IL252116B (ru) |
MA (1) | MA40982A (ru) |
MX (1) | MX2017006562A (ru) |
WO (1) | WO2016081676A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10085961B2 (en) | 2015-06-01 | 2018-10-02 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of dimethyl fumarate |
CA3013472A1 (en) * | 2016-02-11 | 2017-08-17 | Biogen Ma Inc. | Pharmaceutical bead formulations comprising dimethyl fumarate |
KR20200018458A (ko) | 2017-06-23 | 2020-02-19 | 알미랄, 에스.에이. | 디메틸 푸마레이트를 포함하는 약학 조성물 |
BR112020013111A2 (pt) * | 2018-01-12 | 2020-12-01 | Metimedi Pharmaceuticals Co., Ltd. | métodos de tratamentos da doença de alzheimer, de esclerose múltipla, de pulpite, de doença inflamatória intestinal e de lesão medular |
TR201818307A2 (tr) * | 2018-11-30 | 2020-06-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Di̇meti̇l fumarat i̇çeren bi̇r kompozi̇syon |
BR112021018452B1 (pt) * | 2019-05-31 | 2022-10-04 | Curacle Co., Ltd | Comprimido de revestimento entérico e seu método de preparação |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5213811A (en) * | 1991-09-13 | 1993-05-25 | Sterling Drug Inc. | Oral sustained-release drug compositions |
ES2157731B1 (es) * | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
DE10101307A1 (de) * | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
NZ528957A (en) * | 2001-04-18 | 2005-05-27 | Nostrum Pharmaceuticals Inc | A novel coating for a sustained release pharmaceutical composition |
DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
GB0419355D0 (en) * | 2004-08-31 | 2004-09-29 | Novartis Ag | Organic compounds |
EP2801354B1 (en) * | 2004-10-08 | 2017-02-08 | Forward Pharma A/S | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
CN101056624A (zh) * | 2004-10-08 | 2007-10-17 | Adi技术制药股份公司 | 包含富马酸酯的控释药物组合物 |
US20120034274A1 (en) * | 2009-01-09 | 2012-02-09 | Forward Pharma A/S | Pharmaceutical composition comprising one or more fumaric acid esters |
KR101699912B1 (ko) * | 2009-01-09 | 2017-01-25 | 포워드 파마 에이/에스 | 1종 이상의 푸마르산 에스테르를 침식 매트릭스에 함유하는 제제 |
WO2010099508A1 (en) * | 2009-02-26 | 2010-09-02 | Theraquest Biosciences, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
HUE025878T2 (en) | 2010-02-12 | 2016-05-30 | Biogen Ma Inc | Neuroprotection in demyelinating diseases |
WO2013076216A1 (en) * | 2011-11-24 | 2013-05-30 | Synthon Bv | Controlled release particles comprising dimethyl fumarate |
CN114146080A (zh) * | 2012-02-07 | 2022-03-08 | 比奥根玛公司 | 含有富马酸二甲酯的药物组合物 |
EP2692343A1 (en) * | 2012-08-03 | 2014-02-05 | Forward Pharma A/S | Combination therapy for treatment of multiple sclerosis |
US20140171504A1 (en) | 2012-12-14 | 2014-06-19 | Georgia Regents Research Institute, Inc. | Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters |
US20140178468A1 (en) * | 2012-12-24 | 2014-06-26 | Ranbaxy Laboratories Limited | Multiparticulate extended-release composition of mesalamine |
WO2014143146A1 (en) * | 2013-03-15 | 2014-09-18 | Xenoport, Inc. | Methods of administering monomethyl fumarate |
CN104027311A (zh) | 2014-05-09 | 2014-09-10 | 万特制药(海南)有限公司 | 一种含有富马酸二甲酯的肠溶缓释微丸 |
-
2015
- 2015-11-18 MA MA040982A patent/MA40982A/fr unknown
- 2015-11-19 KR KR1020177015943A patent/KR20170086063A/ko active IP Right Grant
- 2015-11-19 IL IL252116A patent/IL252116B/en unknown
- 2015-11-19 EP EP15801649.3A patent/EP3220898A1/en active Pending
- 2015-11-19 CA CA2967647A patent/CA2967647A1/en active Pending
- 2015-11-19 CN CN202110852686.7A patent/CN113521029A/zh active Pending
- 2015-11-19 AU AU2015349896A patent/AU2015349896B2/en active Active
- 2015-11-19 MX MX2017006562A patent/MX2017006562A/es unknown
- 2015-11-19 WO PCT/US2015/061456 patent/WO2016081676A1/en active Application Filing
- 2015-11-19 US US15/527,531 patent/US11197842B2/en active Active
- 2015-11-19 JP JP2017527359A patent/JP6843748B2/ja active Active
- 2015-11-19 EA EA201791113A patent/EA039157B1/ru unknown
- 2015-11-19 CN CN201580073821.0A patent/CN107205937A/zh active Pending
-
2018
- 2018-03-18 HK HK18103739.0A patent/HK1244214A1/zh unknown
-
2021
- 2021-02-22 JP JP2021026223A patent/JP2021088586A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US11197842B2 (en) | 2021-12-14 |
MX2017006562A (es) | 2018-02-19 |
CA2967647A1 (en) | 2016-05-26 |
AU2015349896A1 (en) | 2017-05-25 |
EP3220898A1 (en) | 2017-09-27 |
US20180153845A1 (en) | 2018-06-07 |
JP2021088586A (ja) | 2021-06-10 |
JP6843748B2 (ja) | 2021-03-17 |
IL252116A0 (en) | 2017-07-31 |
KR20170086063A (ko) | 2017-07-25 |
WO2016081676A1 (en) | 2016-05-26 |
MA40982A (fr) | 2017-09-26 |
CN107205937A (zh) | 2017-09-26 |
CN113521029A (zh) | 2021-10-22 |
HK1244214A1 (zh) | 2018-08-03 |
JP2017534668A (ja) | 2017-11-24 |
IL252116B (en) | 2022-08-01 |
AU2015349896B2 (en) | 2021-04-29 |
EA039157B1 (ru) | 2021-12-13 |
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