EA201790985A1 - Новые соли (3r)-3-циклопентил-3-[4-(7h-пирроло[2,3-d]пиримидин-4-ил)пиразол-1-ил]пропаннитрила - Google Patents
Новые соли (3r)-3-циклопентил-3-[4-(7h-пирроло[2,3-d]пиримидин-4-ил)пиразол-1-ил]пропаннитрилаInfo
- Publication number
- EA201790985A1 EA201790985A1 EA201790985A EA201790985A EA201790985A1 EA 201790985 A1 EA201790985 A1 EA 201790985A1 EA 201790985 A EA201790985 A EA 201790985A EA 201790985 A EA201790985 A EA 201790985A EA 201790985 A1 EA201790985 A1 EA 201790985A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- acid
- pyrrolo
- pyrazol
- pyrimidin
- propnanitril
- Prior art date
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 2
- RJWBTWIBUIGANW-UHFFFAOYSA-N 4-chlorobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C(Cl)C=C1 RJWBTWIBUIGANW-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- 229940092714 benzenesulfonic acid Drugs 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 abstract 1
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ2014-773A CZ2014773A3 (cs) | 2014-11-10 | 2014-11-10 | Soli (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu |
| PCT/CZ2015/000133 WO2016074650A1 (en) | 2014-11-10 | 2015-11-05 | Salts of (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201790985A1 true EA201790985A1 (ru) | 2017-08-31 |
Family
ID=54608211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201790985A EA201790985A1 (ru) | 2014-11-10 | 2015-11-05 | Новые соли (3r)-3-циклопентил-3-[4-(7h-пирроло[2,3-d]пиримидин-4-ил)пиразол-1-ил]пропаннитрила |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3218379A1 (cs) |
| CZ (1) | CZ2014773A3 (cs) |
| EA (1) | EA201790985A1 (cs) |
| WO (1) | WO2016074650A1 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2015496A3 (cs) * | 2015-07-14 | 2017-01-25 | Zentiva, K.S. | Krystalické formy solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a jejich příprava |
| CN110494435B (zh) | 2017-06-07 | 2022-02-15 | 四川科伦博泰生物医药股份有限公司 | 氮杂环丁烷衍生物的固体形式及其制备方法和用途 |
| CA3139457A1 (en) * | 2021-11-19 | 2023-05-19 | Apotex Inc. | Novel salts of ruxolitinib and crystalline forms thereof |
| WO2024028193A1 (en) | 2022-08-03 | 2024-02-08 | Medichem, S.A. | Stable oral pharmaceutical formulation containing ruxolitinib hemifumarate |
| WO2024099396A1 (zh) * | 2022-11-11 | 2024-05-16 | 浙江奥翔药业股份有限公司 | 芦可替尼晶体及其药物组合物 |
| EP4491175A1 (en) | 2023-07-10 | 2025-01-15 | Genepharm S.A. | A solid oral composition of ruxolitinib |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2455382T (pt) | 2005-12-13 | 2017-01-31 | Incyte Holdings Corp | Pirrolo[2,3-b]piridinas e pirrolo[2,3-b]pirimidinas substituídas por heteroarilo como inibidores de janus quinases |
| ES2903444T3 (es) | 2007-06-13 | 2022-04-01 | Incyte Holdings Corp | Uso de sales del inhibidor de quinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| UA111588C2 (uk) * | 2010-05-21 | 2016-05-25 | Інсайт Холдінгс Корпорейшн | Композиція інгібітора jak для місцевого застосування |
| NZ618367A (en) * | 2011-06-14 | 2016-01-29 | Novartis Ag | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
-
2014
- 2014-11-10 CZ CZ2014-773A patent/CZ2014773A3/cs unknown
-
2015
- 2015-11-05 EP EP15797582.2A patent/EP3218379A1/en not_active Withdrawn
- 2015-11-05 EA EA201790985A patent/EA201790985A1/ru unknown
- 2015-11-05 WO PCT/CZ2015/000133 patent/WO2016074650A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016074650A1 (en) | 2016-05-19 |
| EP3218379A1 (en) | 2017-09-20 |
| CZ2014773A3 (cs) | 2016-05-18 |
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