EA201790051A1 - Лечение хронического заболевания почек и другого нарушения функции почек при помощи модулятора gdf15 - Google Patents

Лечение хронического заболевания почек и другого нарушения функции почек при помощи модулятора gdf15

Info

Publication number
EA201790051A1
EA201790051A1 EA201790051A EA201790051A EA201790051A1 EA 201790051 A1 EA201790051 A1 EA 201790051A1 EA 201790051 A EA201790051 A EA 201790051A EA 201790051 A EA201790051 A EA 201790051A EA 201790051 A1 EA201790051 A1 EA 201790051A1
Authority
EA
Eurasian Patent Office
Prior art keywords
renal
kidneys
damage
treatment
chronic disease
Prior art date
Application number
EA201790051A
Other languages
English (en)
Russian (ru)
Inventor
Джено Гьюрис
Лорена Лернер
Original Assignee
Авео Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авео Фармасьютикалз, Инк. filed Critical Авео Фармасьютикалз, Инк.
Publication of EA201790051A1 publication Critical patent/EA201790051A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201790051A 2014-06-20 2015-06-19 Лечение хронического заболевания почек и другого нарушения функции почек при помощи модулятора gdf15 EA201790051A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462015242P 2014-06-20 2014-06-20
PCT/US2015/036794 WO2015196145A1 (en) 2014-06-20 2015-06-19 Treatment of chronic kidney disease and other renal dysfunction using a gdf15 modulator

Publications (1)

Publication Number Publication Date
EA201790051A1 true EA201790051A1 (ru) 2017-04-28

Family

ID=53724443

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790051A EA201790051A1 (ru) 2014-06-20 2015-06-19 Лечение хронического заболевания почек и другого нарушения функции почек при помощи модулятора gdf15

Country Status (8)

Country Link
US (2) US20170137506A1 (enExample)
EP (1) EP3157953B1 (enExample)
JP (1) JP6768527B2 (enExample)
AU (2) AU2015276800B2 (enExample)
CA (1) CA2952032C (enExample)
EA (1) EA201790051A1 (enExample)
MX (1) MX2016016826A (enExample)
WO (1) WO2015196145A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014100689A1 (en) 2012-12-21 2014-06-26 Aveo Pharmaceuticals, Inc. Anti-gdf15 antibodies
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
US10603359B2 (en) 2014-10-30 2020-03-31 Acceleron Pharma Inc. Methods and compositions using GDF15 polypeptides for increasing red blood cells
WO2017109706A1 (en) * 2015-12-22 2017-06-29 Novartis Ag Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
EP4006049A1 (en) * 2016-01-29 2022-06-01 Washington University Gdf15 in glaucoma and methods of use thereof
JP7138567B2 (ja) 2016-04-27 2022-09-16 ノバルティス アーゲー 成長分化因子１５に対する抗体およびそれらの使用

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IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5733254A (en) 1987-10-15 1998-03-31 Cypress Bioscience, Inc. Method for treating patients suffering from immune thrombocytopenic purpura
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
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IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
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ES2555956T3 (es) * 2004-04-13 2016-01-11 St Vincent's Hospital Sydney Limited Método para modular el apetito
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WO2010048670A1 (en) * 2008-10-31 2010-05-06 St Vincent's Hospital Sydney Limited Method of prognosis in chronic kidney disease
EP3590537A1 (en) * 2012-09-26 2020-01-08 Julius-Maximilians-Universität Würzburg Monoclonal antibodies to growth and differentiation factor 15 (gdf-15)
WO2014100689A1 (en) * 2012-12-21 2014-06-26 Aveo Pharmaceuticals, Inc. Anti-gdf15 antibodies

Also Published As

Publication number Publication date
BR112016029820A2 (pt) 2017-10-24
WO2015196145A1 (en) 2015-12-23
JP6768527B2 (ja) 2020-10-14
CA2952032A1 (en) 2015-12-23
US11897948B2 (en) 2024-02-13
JP2017519764A (ja) 2017-07-20
US20170137506A1 (en) 2017-05-18
MX2016016826A (es) 2017-08-28
AU2015276800B2 (en) 2021-03-04
AU2015276800A1 (en) 2017-01-05
EP3157953B1 (en) 2021-12-22
CA2952032C (en) 2023-03-14
US20190292252A1 (en) 2019-09-26
AU2021203523A1 (en) 2021-07-01
EP3157953A1 (en) 2017-04-26

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