EA201690757A1 - METHOD OF OBTAINING IOPROMIDE INTERMEDIATE CONNECTION - Google Patents

METHOD OF OBTAINING IOPROMIDE INTERMEDIATE CONNECTION

Info

Publication number
EA201690757A1
EA201690757A1 EA201690757A EA201690757A EA201690757A1 EA 201690757 A1 EA201690757 A1 EA 201690757A1 EA 201690757 A EA201690757 A EA 201690757A EA 201690757 A EA201690757 A EA 201690757A EA 201690757 A1 EA201690757 A1 EA 201690757A1
Authority
EA
Eurasian Patent Office
Prior art keywords
iopromide
obtaining
intermediate connection
dioxane
producing
Prior art date
Application number
EA201690757A
Other languages
Russian (ru)
Other versions
EA031801B1 (en
Inventor
Ёнг Сук Джин
Вол Юнг Ким
Джун Хван Ли
Сынг Тэ Ким
Санг Хьюн Ким
Хи Кьюн Юн
Original Assignee
Дэвунг Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дэвунг Фармасьютикал Ко., Лтд. filed Critical Дэвунг Фармасьютикал Ко., Лтд.
Publication of EA201690757A1 publication Critical patent/EA201690757A1/en
Publication of EA031801B1 publication Critical patent/EA031801B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Настоящее изобретение относится к способу получения промежуточного соединения иопромида, и в частности, к способу получения промежуточного соединения иопромида, в котором дихлорангидрид 5-метоксиацетиламино-2,4,6-трииодизофталевой кислоты получается при использовании 1,4-диоксана в качестве растворителя реакции, и затем взаимодействует с 3-амино-1,2-пропандиолом при использовании смеси растворителей, состоящей из 1,4-диоксана или тетрагидрофурана (ТГФ) и изопропанола, в качестве растворителя реакции с получением промежуточного соединения иопромида, с более быстрым временем реакции, меньшим количеством растворителя и более высоким выходом.The present invention relates to a method for producing an intermediate of iopromide, and in particular, to a method for producing an intermediate of iopromide, in which 5-methoxy-acetylamino-2,4,6-triiodisophthalic acid dichloride is obtained using 1,4-dioxane as a reaction solvent, and then reacts with 3-amino-1,2-propanediol using a mixture of solvents consisting of 1,4-dioxane or tetrahydrofuran (THF) and isopropanol as the reaction solvent to produce an intermediate iopromide, with faster reaction time, less solvent and higher yield.

EA201690757A 2013-10-25 2014-10-23 Method for preparing an intermediate of iopromide EA031801B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130128154A KR101520187B1 (en) 2013-10-25 2013-10-25 A method for preparation of an intermediate of iopromide
PCT/KR2014/009991 WO2015060657A1 (en) 2013-10-25 2014-10-23 A method for preparing an intermediate of iopromide

Publications (2)

Publication Number Publication Date
EA201690757A1 true EA201690757A1 (en) 2016-10-31
EA031801B1 EA031801B1 (en) 2019-02-28

Family

ID=52993179

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690757A EA031801B1 (en) 2013-10-25 2014-10-23 Method for preparing an intermediate of iopromide

Country Status (7)

Country Link
KR (1) KR101520187B1 (en)
CN (1) CN105636933B (en)
EA (1) EA031801B1 (en)
PH (1) PH12016500749A1 (en)
SA (1) SA516370977B1 (en)
UA (1) UA114158C2 (en)
WO (1) WO2015060657A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110078636B (en) * 2019-05-23 2022-05-17 浙江海洲制药有限公司 Method for preparing iopromide intermediate
CN114436880B (en) * 2020-11-03 2023-04-28 成都倍特药业股份有限公司 Preparation method of iopromide intermediate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media
AU5093993A (en) * 1992-09-02 1994-03-29 Mallinckrodt Medical, Inc. Nonionic X-ray contrast agents compositions and methods
IT1286522B1 (en) 1996-12-04 1998-07-15 Dibra Spa PROCESS FOR THE PREPARATION OF DERIVATIVES OF 5-AMINO-2,4,6- TRIIODO-1,3-BENZENEDICICARBOXYLIC ACID
IT1292037B1 (en) 1997-05-30 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF 5- (ACETYL 62,3-DIIDROXYPROPYL) - AMINO) -N, N'-BIS (2,3-DIIDROXYPROPYL) -2,4,6-TRIIODE-1,3-BENZEN-
KR100286639B1 (en) * 1999-03-31 2001-04-16 강재헌 Process for preparing iopromide
WO2009071605A1 (en) * 2007-12-05 2009-06-11 Ge Healthcare As Contrast agents
KR101098553B1 (en) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 Novel Process for Preparation of Iopromide

Also Published As

Publication number Publication date
KR20150047997A (en) 2015-05-06
PH12016500749B1 (en) 2016-06-13
SA516370977B1 (en) 2017-08-21
EA031801B1 (en) 2019-02-28
KR101520187B1 (en) 2015-05-13
WO2015060657A1 (en) 2015-04-30
CN105636933B (en) 2017-12-15
UA114158C2 (en) 2017-04-25
CN105636933A (en) 2016-06-01
PH12016500749A1 (en) 2016-06-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU