EA201590657A1 - Method of producing high-purity potassium salt of azilsarethan medoxomil - Google Patents

Method of producing high-purity potassium salt of azilsarethan medoxomil

Info

Publication number
EA201590657A1
EA201590657A1 EA201590657A EA201590657A EA201590657A1 EA 201590657 A1 EA201590657 A1 EA 201590657A1 EA 201590657 A EA201590657 A EA 201590657A EA 201590657 A EA201590657 A EA 201590657A EA 201590657 A1 EA201590657 A1 EA 201590657A1
Authority
EA
Eurasian Patent Office
Prior art keywords
medoxomil
potassium salt
azilsarethan
producing high
purity potassium
Prior art date
Application number
EA201590657A
Other languages
Russian (ru)
Other versions
EA028171B1 (en
Inventor
Ян Стах
Радим Крулис
Йосеф Церны
Лудек Ридван
Ондрей Даммер
Лукас Крейцик
Станислав Радл
Original Assignee
Зентива К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива К.С. filed Critical Зентива К.С.
Publication of EA201590657A1 publication Critical patent/EA201590657A1/en
Publication of EA028171B1 publication Critical patent/EA028171B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)

Abstract

Способ получения калиевой соли азилсартана медоксомила формулы I, при котором получают сольват азилсартана медоксомила формулы II с растворителем, выбранным из группы, состоящей из диметилацетамида или N-метилпирролидона или их смесей, либо перекристаллизуют из диметилацетамида или N-метилпирролидона, либо их смесей с другими растворителями, и на следующей стадии преобразуют в калиевую соль, используя источник калия в подходящем растворителе.The method of obtaining the azylsartan potassium salt of medoxomil of formula I, in which an azilsartan medoxomil solvate of formula II is obtained with a solvent selected from the group consisting of dimethylacetamide or N-methylpyrrolidone or mixtures thereof, or recrystallized from dimethylacetamide or N-methylpyrrolidone, or mixtures thereof with other solvents , and in the next step, is converted to the potassium salt using a potassium source in a suitable solvent.

EA201590657A 2012-09-26 2013-09-25 Method of preparing a highly pure potassium salt of azilsartan medoxomil EA028171B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2012-663A CZ305318B6 (en) 2012-09-26 2012-09-26 Process for preparing extremely pure azilsartan medoxomil potassium salt
PCT/CZ2013/000114 WO2014048404A1 (en) 2012-09-26 2013-09-25 A method of preparing a highly pure potassium salt of azilsartan medoxomil

Publications (2)

Publication Number Publication Date
EA201590657A1 true EA201590657A1 (en) 2015-08-31
EA028171B1 EA028171B1 (en) 2017-10-31

Family

ID=66624776

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590657A EA028171B1 (en) 2012-09-26 2013-09-25 Method of preparing a highly pure potassium salt of azilsartan medoxomil

Country Status (12)

Country Link
EP (1) EP2900662A1 (en)
JP (1) JP2015532267A (en)
KR (1) KR20150060733A (en)
CN (1) CN104662019A (en)
BR (1) BR112015006572A2 (en)
CZ (1) CZ305318B6 (en)
EA (1) EA028171B1 (en)
HK (1) HK1205505A1 (en)
IL (1) IL237884A0 (en)
MX (1) MX2015003209A (en)
UA (1) UA113668C2 (en)
WO (1) WO2014048404A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2014702A3 (en) * 2014-10-15 2016-04-27 Zentiva, K.S. Process for preparing extremely pure azilsartan
CN105753854A (en) * 2014-12-16 2016-07-13 重庆朗天制药有限公司 New preparation method of azilsartan kamedoxomil
CN109071519A (en) * 2016-01-28 2018-12-21 株式会社德山 Azilsartan and its manufacturing method
CN108727356A (en) * 2018-06-28 2018-11-02 江苏新瑞药业有限公司 A kind of synthetic method of olmesartan medoxomil alkali metal salt

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157584B2 (en) 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
WO2012090043A1 (en) * 2010-12-29 2012-07-05 Jubilant Life Sciences Limited Novel solid state forms of azilsartan medoxomil and preparation thereof
JP2014505097A (en) * 2011-02-08 2014-02-27 ジュビラント ライフ サイエンセズ リミテッド Improved production method of azilsartan medoxomil
WO2013042067A1 (en) * 2011-09-20 2013-03-28 Ranbaxy Laboratories Limited Process for the preparation of potassium salt of azilsartan medoxomil
WO2013104342A1 (en) * 2012-01-14 2013-07-18 Sunshine Lake Pharma Co., Ltd. Crystalline forms of azilsartan medoxomil potassium and preparation and uses thereof
CZ2012274A3 (en) * 2012-04-19 2013-10-30 Zentiva, K.S. Process for preparing extremely pure potassium salt of azilsartan medoxomil

Also Published As

Publication number Publication date
KR20150060733A (en) 2015-06-03
BR112015006572A2 (en) 2017-07-04
EA028171B1 (en) 2017-10-31
JP2015532267A (en) 2015-11-09
UA113668C2 (en) 2017-02-27
CN104662019A (en) 2015-05-27
CZ305318B6 (en) 2015-07-29
EP2900662A1 (en) 2015-08-05
IL237884A0 (en) 2015-05-31
MX2015003209A (en) 2015-07-14
HK1205505A1 (en) 2015-12-18
CZ2012663A3 (en) 2014-04-02
WO2014048404A1 (en) 2014-04-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU