TH171362A - Method for the preparation of iopromide intermediates (iopromide) - Google Patents
Method for the preparation of iopromide intermediates (iopromide)Info
- Publication number
- TH171362A TH171362A TH1601002321A TH1601002321A TH171362A TH 171362 A TH171362 A TH 171362A TH 1601002321 A TH1601002321 A TH 1601002321A TH 1601002321 A TH1601002321 A TH 1601002321A TH 171362 A TH171362 A TH 171362A
- Authority
- TH
- Thailand
- Prior art keywords
- iopromide
- preparation
- intermediates
- chemical formula
- dioxane
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract 4
- DGAIEPBNLOQYER-UHFFFAOYSA-N Iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 title abstract 6
- 229960002603 Iopromide Drugs 0.000 title abstract 6
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 claims abstract 7
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000005712 crystallization Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 4
- PZLOICVTWKCKRK-UHFFFAOYSA-L 2,4,6-triiodo-5-[(2-methoxyacetyl)amino]benzene-1,3-dicarboxylic acid;dichloride Chemical compound [Cl-].[Cl-].COCC(=O)NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I PZLOICVTWKCKRK-UHFFFAOYSA-L 0.000 abstract 1
- KQIGMPWTAHJUMN-UHFFFAOYSA-N 3-aminopropane-1,2-diol Chemical compound NCC(O)CO KQIGMPWTAHJUMN-UHFFFAOYSA-N 0.000 abstract 1
- IIMIOEBMYPRQGU-UHFFFAOYSA-L Picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับวิธีการสำหรับการเตรียมสารสื่อกลางของไอโอไพรไมด์ (iopromide) และโดยเฉพาะอย่างยิ่ง วิธีการสำหรับการเตรียมสารสื่อกลางของไอโอโพรไมด์ (iopromide) ที่ซึ่ง 5-เมทอก ซึอะซิติลอะมิโน-2,4,6- ไตรไอโอโดไอโซพทาลิคแอซิดไดคลอไรด์ (5-methoxyacetylamino-2,4,6- triiodoisophthalic acid dichloride) ถูกผลิตขึ้นโดยใช้ 1,4- ไดออกเซน เป็นตัวทำลายของการเกิดปฎิกิริยา และจากนั้นทำปฎิกิริยากับ 3-อะมิโน-1,2-โพรเพนไดออล โดยใช้ตัวลำลายผสมของ1,4-ไดออกเซน หรือ เตตระไฮโดรฟูแรน (THF) และไอโซโพรพานอลเป็น ตัวทำลายของการเกิดปฎิกิริยา เพื่อให้ได้สาร สื่อกลางของไอโอโพรไมด์ ด้วยเวลาในการทำปฎิกิริยาที่เร็วกว่า, ปริมาณของตัวทำลายน้อยกว่าและ อัตราผลตอบแทนที่สูงขั้น This invention relates to a method for the preparation of iopromide mediators (iopromide) and, in particular, A method for the preparation of iopromide intermediates, in which 5-methyl-amino-2,4,6-triiodoisopthalic acid Zid dichloride (5-methoxyacetylamino-2,4,6- triiodoisophthalic acid dichloride) is produced using 1,4-dioxane as a reaction agent. And then react with 3-amino-1,2-propanediol A mixture of 1,4-dioxane or tetrahydrofuran (THF) and isopropanol was used as The destroyer of the reaction To get the substance Iopromide medium With a faster reaction time, less amount of destroyer and High yield
Claims (2)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH1601002321A TH1601002321A (en) | 2017-12-07 |
| TH171362B TH171362B (en) | 2017-12-07 |
| TH171362A true TH171362A (en) | 2017-12-07 |
Family
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