EA201690141A1 - Получение хиральных 4-хроманонов с применением хиральных пирролидинов - Google Patents
Получение хиральных 4-хроманонов с применением хиральных пирролидиновInfo
- Publication number
- EA201690141A1 EA201690141A1 EA201690141A EA201690141A EA201690141A1 EA 201690141 A1 EA201690141 A1 EA 201690141A1 EA 201690141 A EA201690141 A EA 201690141A EA 201690141 A EA201690141 A EA 201690141A EA 201690141 A1 EA201690141 A1 EA 201690141A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- chiral
- chromanons
- pyrrolidines
- obtaining
- synthesis
- Prior art date
Links
- 150000003235 pyrrolidines Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- MSTDXOZUKAQDRL-UHFFFAOYSA-N 4-Chromanone Chemical compound C1=CC=C2C(=O)CCOC2=C1 MSTDXOZUKAQDRL-UHFFFAOYSA-N 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001843 chromanes Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Настоящее изобретение касается стереоспецифического синтеза хроманонов или хроманов в отношении положения 2 в хроманоновом или хромановом цикле. Было обнаружено, что данный синтез, в частности, возможен в присутствии хирального соединения, имеющего особую формулу.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13175317 | 2013-07-05 | ||
| PCT/EP2014/064210 WO2015001031A1 (en) | 2013-07-05 | 2014-07-03 | Formation of chiral 4-chromanones using chiral pyrrolidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690141A1 true EA201690141A1 (ru) | 2016-06-30 |
| EA030614B1 EA030614B1 (ru) | 2018-08-31 |
Family
ID=48746340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690141A EA030614B1 (ru) | 2013-07-05 | 2014-07-03 | Получение хиральных 4-хроманонов с применением хиральных пирролидинов |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160152588A1 (ru) |
| EP (1) | EP3016942B1 (ru) |
| JP (1) | JP6365949B2 (ru) |
| CN (1) | CN105358542B (ru) |
| BR (1) | BR112015033013B1 (ru) |
| EA (1) | EA030614B1 (ru) |
| WO (1) | WO2015001031A1 (ru) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH619701A5 (ru) * | 1975-08-07 | 1980-10-15 | Bayer Ag | |
| DE19843672A1 (de) | 1998-09-23 | 2000-03-30 | Basf Ag | Verfahren zur Herstellung von Chromanol-Derivaten |
| ATE520678T1 (de) | 2004-12-22 | 2011-09-15 | Dsm Ip Assets Bv | Asymmetrische hydrierung von alkenen mit chiralem iridiumkomplex |
| CN101778810A (zh) | 2007-08-08 | 2010-07-14 | 帝斯曼知识产权资产管理有限公司 | (e,e)-法尼基丙酮的制备方法 |
| EP2522647B1 (en) | 2011-05-10 | 2014-04-30 | DSM IP Assets B.V. | Process of separating chiral isomers of chroman compounds and their derivatives and precursors |
-
2014
- 2014-07-03 US US14/902,873 patent/US20160152588A1/en not_active Abandoned
- 2014-07-03 BR BR112015033013-4A patent/BR112015033013B1/pt active IP Right Grant
- 2014-07-03 CN CN201480038046.0A patent/CN105358542B/zh active Active
- 2014-07-03 EA EA201690141A patent/EA030614B1/ru not_active IP Right Cessation
- 2014-07-03 JP JP2016522629A patent/JP6365949B2/ja active Active
- 2014-07-03 WO PCT/EP2014/064210 patent/WO2015001031A1/en active Application Filing
- 2014-07-03 EP EP14735951.7A patent/EP3016942B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015001031A1 (en) | 2015-01-08 |
| EP3016942A1 (en) | 2016-05-11 |
| BR112015033013B1 (pt) | 2021-12-07 |
| CN105358542A (zh) | 2016-02-24 |
| US20160152588A1 (en) | 2016-06-02 |
| CN105358542B (zh) | 2017-10-24 |
| JP6365949B2 (ja) | 2018-08-01 |
| JP2016523882A (ja) | 2016-08-12 |
| EP3016942B1 (en) | 2017-03-01 |
| BR112015033013A2 (pt) | 2017-07-25 |
| EA030614B1 (ru) | 2018-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |