WO2014111903A3 - A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde - Google Patents

A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde Download PDF

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Publication number
WO2014111903A3
WO2014111903A3 PCT/IB2014/058437 IB2014058437W WO2014111903A3 WO 2014111903 A3 WO2014111903 A3 WO 2014111903A3 IB 2014058437 W IB2014058437 W IB 2014058437W WO 2014111903 A3 WO2014111903 A3 WO 2014111903A3
Authority
WO
WIPO (PCT)
Prior art keywords
chromene
dihydro
preparation
carbaldehyde
fluoro
Prior art date
Application number
PCT/IB2014/058437
Other languages
French (fr)
Other versions
WO2014111903A2 (en
Inventor
Rajiv Indravadan Modi
Aminmahamad Nasiruddin ISMAILI
Dipak Bhikanrao RAUT
Javedhusen Karimbhai MANSURI
Chaitanya Chhotubhai DESAI
Original Assignee
Cadila Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Limited filed Critical Cadila Pharmaceuticals Limited
Publication of WO2014111903A2 publication Critical patent/WO2014111903A2/en
Publication of WO2014111903A3 publication Critical patent/WO2014111903A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a process for ihe preparation of 6-f!uoro-3,4-dihydro- 2H-chromene-2-carbaidehyde which is useful as an Intermediate in the synthesis of Nebivolol or its pharmaceutical acceptable salts.
PCT/IB2014/058437 2013-01-21 2014-01-21 A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde WO2014111903A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN184MU2013 2013-01-21
IN184/MUM/2013 2013-01-21

Publications (2)

Publication Number Publication Date
WO2014111903A2 WO2014111903A2 (en) 2014-07-24
WO2014111903A3 true WO2014111903A3 (en) 2014-10-23

Family

ID=50439425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/058437 WO2014111903A2 (en) 2013-01-21 2014-01-21 A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde

Country Status (1)

Country Link
WO (1) WO2014111903A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110156765A (en) * 2019-06-09 2019-08-23 河南师范大学 The method that the one kettle way that hydrogen bonding functionality ionic liquid promotes prepares 2- amino -4H- chromene derivative
CN110054607A (en) * 2019-06-09 2019-07-26 河南师范大学 The method for the one pot process 2- amino -3- itrile group -7- hydroxyl -4H- chromene derivative that bursine promotes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102329291A (en) * 2011-07-27 2012-01-25 上海现代制药股份有限公司 Method for preparing 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-formaldehyde

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3444098A1 (en) 1984-12-04 1986-06-05 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING 2- (1-HYDROXYMETHYL) -ACRYLNITRILE AND -ACRYL ESTERS
CA1337432C (en) 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102329291A (en) * 2011-07-27 2012-01-25 上海现代制药股份有限公司 Method for preparing 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-formaldehyde

Also Published As

Publication number Publication date
WO2014111903A2 (en) 2014-07-24

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