EA201591683A1 - Способы лечения, снижения частоты и/или профилактики ишемических событий - Google Patents

Способы лечения, снижения частоты и/или профилактики ишемических событий

Info

Publication number
EA201591683A1
EA201591683A1 EA201591683A EA201591683A EA201591683A1 EA 201591683 A1 EA201591683 A1 EA 201591683A1 EA 201591683 A EA201591683 A EA 201591683A EA 201591683 A EA201591683 A EA 201591683A EA 201591683 A1 EA201591683 A1 EA 201591683A1
Authority
EA
Eurasian Patent Office
Prior art keywords
frequency
methods
ischemic event
patient
treating
Prior art date
Application number
EA201591683A
Other languages
English (en)
Other versions
EA034550B1 (ru
Inventor
Клив Артур Аркулус-Минвелл
Симона Скержанек
Джейн Пратс
Дэвид Дж. Шнейдер
Original Assignee
Зе Медисинс Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/792,056 external-priority patent/US9427448B2/en
Application filed by Зе Медисинс Компани filed Critical Зе Медисинс Компани
Publication of EA201591683A1 publication Critical patent/EA201591683A1/ru
Publication of EA034550B1 publication Critical patent/EA034550B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Способы лечения, снижения частоты и/или профилактики ишемического события у пациента, подвергаемого чрескожной коронарной ангиопластике (PCI), включающий введение пациенту фармацевтической композиции, содержащей кангрелор. Способ может дополнительно включать введение пациенту дополнительного терапевтического средства, где дополнительное терапевтическое средство содержит ингибитор P2Y. Фармацевтические композиции, пригодные для лечения, снижения частоты и/или профилактики ишемического события у пациента, подвергаемого PCI. Фармацевтические композиции содержат кангрелор. Способы получения фармацевтической композиции для лечения, снижения частоты и/или профилактики ишемического события у пациента, подвергаемого PCI, включающие смешивание кангрелора с одним или несколькими фармацевтически приемлемыми эксципиентами. Ишемическое событие может включать тромбоз стента, инфаркт миокарда, обусловленную ишемией реваскуляризацию и смертельный исход.
EA201591683A 2013-03-09 2013-05-29 Способы лечения, снижения частоты и/или профилактики ишемических событий EA034550B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/792,056 US9427448B2 (en) 2009-11-11 2013-03-09 Methods of treating, reducing the incidence of, and/or preventing ischemic events
US201361815735P 2013-04-25 2013-04-25
PCT/US2013/043136 WO2014143107A1 (en) 2013-03-09 2013-05-29 Methods of treating, reducing the incidence of, and/or preventing ischemic events

Publications (2)

Publication Number Publication Date
EA201591683A1 true EA201591683A1 (ru) 2016-08-31
EA034550B1 EA034550B1 (ru) 2020-02-19

Family

ID=51537409

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591683A EA034550B1 (ru) 2013-03-09 2013-05-29 Способы лечения, снижения частоты и/или профилактики ишемических событий

Country Status (10)

Country Link
EP (2) EP2964233B1 (ru)
JP (3) JP6247708B2 (ru)
CN (2) CN106102750A (ru)
AU (1) AU2013381855B2 (ru)
BR (1) BR112015022070B1 (ru)
CA (1) CA2904523C (ru)
EA (1) EA034550B1 (ru)
ES (1) ES2904256T3 (ru)
PL (1) PL2964233T3 (ru)
WO (1) WO2014143107A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019015448A (es) * 2017-06-23 2020-02-19 Chiesi Farm Spa Metodo para la prevencion de trombosis de desviacion de la arteria sistemica a pulmonar.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69406649T2 (de) 1993-02-10 1998-03-05 Astra Pharma Prod N-alkyl-2-substituierte atp-analoge
ID21635A (id) 1996-12-20 1999-07-08 Astra Pharma Prod Komposisi farmasi untuk pengeringan beku
SE9702680D0 (sv) 1997-07-11 1997-07-11 Astra Pharma Prod New formulation
SE9904377D0 (sv) 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
WO2009140092A1 (en) * 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US9427448B2 (en) * 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20100297675A1 (en) * 2008-11-24 2010-11-25 Huayun Deng Substrate and method for culturing breast cells
CA2778880C (en) * 2009-11-11 2018-02-13 The Medicines Company Methods of treating or preventing stent thrombosis

Also Published As

Publication number Publication date
JP2018002739A (ja) 2018-01-11
AU2013381855A1 (en) 2015-10-22
EP3978002A1 (en) 2022-04-06
JP2019178177A (ja) 2019-10-17
JP2016510738A (ja) 2016-04-11
PL2964233T3 (pl) 2022-04-25
WO2014143107A1 (en) 2014-09-18
EP2964233A1 (en) 2016-01-13
CN106102750A (zh) 2016-11-09
BR112015022070A2 (pt) 2017-07-18
CA2904523C (en) 2024-01-09
EP2964233B1 (en) 2021-12-15
JP6247708B2 (ja) 2017-12-13
EA034550B1 (ru) 2020-02-19
CA2904523A1 (en) 2014-09-18
JP6840197B2 (ja) 2021-03-10
AU2013381855B2 (en) 2018-08-02
CN115120606A (zh) 2022-09-30
ES2904256T3 (es) 2022-04-04
EP2964233A4 (en) 2016-10-19
BR112015022070B1 (pt) 2022-01-18

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