EA201500407A1 - METHOD OF OBTAINING FLAVONOIDS THAT HAVE BIOLOGICAL ACTIVITY - Google Patents

METHOD OF OBTAINING FLAVONOIDS THAT HAVE BIOLOGICAL ACTIVITY

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Publication number
EA201500407A1
EA201500407A1 EA201500407A EA201500407A EA201500407A1 EA 201500407 A1 EA201500407 A1 EA 201500407A1 EA 201500407 A EA201500407 A EA 201500407A EA 201500407 A EA201500407 A EA 201500407A EA 201500407 A1 EA201500407 A1 EA 201500407A1
Authority
EA
Eurasian Patent Office
Prior art keywords
evaporation
alcohol
water
dry residue
crystals
Prior art date
Application number
EA201500407A
Other languages
Russian (ru)
Other versions
EA026414B1 (en
Inventor
Джамиля Юсиф кызы Юсифова
Исрафиль Солтан Оглы Мовсумов
Original Assignee
Азербайджанский Медицинский Университет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Азербайджанский Медицинский Университет filed Critical Азербайджанский Медицинский Университет
Priority to EA201500407A priority Critical patent/EA026414B1/en
Publication of EA201500407A1 publication Critical patent/EA201500407A1/en
Publication of EA026414B1 publication Critical patent/EA026414B1/en

Links

Abstract

Изобретение относится к химико-фармацевтической промышленности и касается способа получения флавоноидов из листьев лещины (Corylus avellana L.), обладающих сосудоукрепляющим, противовоспалительным, гепатотропным, антиоксидантным действиями, для создания лекарственных препаратов. Сущность способа состоит в экстракции листьев лещины обыкновенной 95%-ным этиловым спиртом, упаривании спирта, прибавлении очищенной воды, упаривании до водного остатка, промывании хлороформом, упаривании очищенного водного раствора, отфильтровывании осадка, упаривании до сухого остатка, дальнейшем растворении в этиловом спирте, концентрировании, отделении кристаллов, упаривании фильтрата до сухого остатка, растворении в очищенной воде, отфильтровывании, упаривании до сухого остатка и объединении осадка из воды с кристаллами из спирта. Полученный целевой продукт является суммой агликонов и гликозидов, состоящей из мирицетина, кемпферола, кверцетина, кверцитрина, афзелина, мирицитрина.The invention relates to the chemical and pharmaceutical industry and relates to a method for producing flavonoids from hazel leaves (Corylus avellana L.), which have vessel strengthening, anti-inflammatory, hepatotropic, antioxidant effects, to create drugs. The essence of the method consists in the extraction of leaves of hazel ordinary 95% ethyl alcohol, evaporation of alcohol, adding purified water, evaporation to water residue, washing with chloroform, evaporation of purified aqueous solution, filtering the precipitate, evaporation to dry residue, further dissolving in ethyl alcohol, concentrated. , the separation of crystals, evaporation of the filtrate to a dry residue, dissolving in purified water, filtering, evaporation to a dry residue and combining the precipitate from water with crystals of alcohol . The obtained target product is the sum of aglycones and glycosides, consisting of myricetin, kaempferol, quercetin, quercitrin, afzelina, myricitrin.

EA201500407A 2014-12-25 2014-12-25 Method for production of flavonoids possessing biological activity EA026414B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201500407A EA026414B1 (en) 2014-12-25 2014-12-25 Method for production of flavonoids possessing biological activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201500407A EA026414B1 (en) 2014-12-25 2014-12-25 Method for production of flavonoids possessing biological activity

Publications (2)

Publication Number Publication Date
EA201500407A1 true EA201500407A1 (en) 2015-11-30
EA026414B1 EA026414B1 (en) 2017-04-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201500407A EA026414B1 (en) 2014-12-25 2014-12-25 Method for production of flavonoids possessing biological activity

Country Status (1)

Country Link
EA (1) EA026414B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA033799B1 (en) * 2017-07-05 2019-11-26 Dzhamilya Yusif Kyzy Yusifova Vessel-strengthening product in the form of ointment
RU2776898C1 (en) * 2021-04-23 2022-07-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for producing myricitrin from the bark of eastern black walnut, exhibiting neurotropic activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2095075C1 (en) * 1993-07-23 1997-11-10 Иркутский государственный медицинский университет Method of preparing the total flavonoids showing antiinflammatory and spasmolytic effect
CN102178707B (en) * 2011-04-11 2013-03-20 黑龙江大学 Corylus plant extract with antioxidant activity and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA033799B1 (en) * 2017-07-05 2019-11-26 Dzhamilya Yusif Kyzy Yusifova Vessel-strengthening product in the form of ointment
RU2776898C1 (en) * 2021-04-23 2022-07-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for producing myricitrin from the bark of eastern black walnut, exhibiting neurotropic activity

Also Published As

Publication number Publication date
EA026414B1 (en) 2017-04-28

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU