EA201390368A1 - Биарильные дифосфиновые лиганды, их промежуточные соединения и их применение в асимметричном катализе - Google Patents

Биарильные дифосфиновые лиганды, их промежуточные соединения и их применение в асимметричном катализе

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Publication number
EA201390368A1
EA201390368A1 EA201390368A EA201390368A EA201390368A1 EA 201390368 A1 EA201390368 A1 EA 201390368A1 EA 201390368 A EA201390368 A EA 201390368A EA 201390368 A EA201390368 A EA 201390368A EA 201390368 A1 EA201390368 A1 EA 201390368A1
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EA
Eurasian Patent Office
Prior art keywords
biarylic
application
intermediate connections
asymmetric catalysis
ligands
Prior art date
Application number
EA201390368A
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English (en)
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EA027889B1 (ru
Inventor
Камалуддин Абдур-Рашид
Вэньли Цзя
Шуймин Лу
Жунвэй Го
Сюаньхуа Чэнь
Дино Аморосо
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Каната Кемикал Текнолоджиз Инк.
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Application filed by Каната Кемикал Текнолоджиз Инк. filed Critical Каната Кемикал Текнолоджиз Инк.
Publication of EA201390368A1 publication Critical patent/EA201390368A1/ru
Publication of EA027889B1 publication Critical patent/EA027889B1/ru

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    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
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    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
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    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
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    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/223—At least two oxygen atoms present in one at least bidentate or bridging ligand
    • B01J31/2234—Beta-dicarbonyl ligands, e.g. acetylacetonates
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    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
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    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
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    • C07F9/40—Esters thereof
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)

Abstract

Настоящее изобретение относится к биарильным дифосфиновым лигандам формулы (В), способам получения лигандов и применению лигандов в металлических катализаторах для асимметричного синтеза. Изобретение также относится к промежуточным соединениям, используемым для получения биарильного дифосфинового лиганда. (Формула (В)).
EA201390368A 2010-09-10 2011-09-09 Биарильные дифосфиновые лиганды, их промежуточные соединения и их применение в асимметричном катализе EA027889B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38149310P 2010-09-10 2010-09-10
PCT/CA2011/001024 WO2012031358A1 (en) 2010-09-10 2011-09-09 Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis

Publications (2)

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EA201390368A1 true EA201390368A1 (ru) 2013-08-30
EA027889B1 EA027889B1 (ru) 2017-09-29

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EA201390368A EA027889B1 (ru) 2010-09-10 2011-09-09 Биарильные дифосфиновые лиганды, их промежуточные соединения и их применение в асимметричном катализе

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US (1) US9062085B2 (ru)
EP (1) EP2614069A4 (ru)
JP (1) JP6006723B2 (ru)
AU (1) AU2011301115B2 (ru)
EA (1) EA027889B1 (ru)
IL (1) IL225096A (ru)
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Publication number Priority date Publication date Assignee Title
WO2014113869A1 (en) * 2013-01-22 2014-07-31 Apotex Technologies Inc. Processes for the preparation of chiral beta amino acid derivatives using asymmetric hydrogenation catalysts
CN103232324B (zh) * 2013-04-12 2016-03-16 广西新晶科技有限公司 一种(r)-3，5-双(三氟甲基)苯乙醇的制备方法
CN103554183A (zh) * 2013-09-11 2014-02-05 南开大学 一种新型多芳基桥联的长链二膦配体合成方法和应用
CN109776245A (zh) * 2017-11-14 2019-05-21 中国科学院大连化学物理研究所 一种铱催化不对称氢化制备手性醇的方法
US11315342B2 (en) * 2019-11-21 2022-04-26 International Business Machines Corporation Automated explanation of machine learning predictions using classification score targeting

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
ATE128140T1 (de) 1989-05-18 1995-10-15 Hoffmann La Roche Phosphorverbindungen.
US5302738A (en) 1991-03-15 1994-04-12 Hoffmann-La Roche Inc. Chiral phosphines
US5886182A (en) * 1997-12-10 1999-03-23 The Hong Kong Polytechnic University Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids
US6162929A (en) * 1997-12-23 2000-12-19 Hoffmann-La Roche Inc. Process for the manufacture of bisphosphine oxide and bisphosphonate compounds
DE10027154A1 (de) * 2000-05-31 2001-12-13 Bayer Ag Verfahren zur Herstellung optisch aktiver Trimethylmilchsäure und ihrer Ester
WO2002040491A1 (en) * 2000-11-17 2002-05-23 The Penn State Research Foundation Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catayltic reactions
CA2703671A1 (en) * 2007-10-30 2009-05-07 Kanata Chemical Technologies Inc. Cationic transition metal catalysts

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JP6006723B2 (ja) 2016-10-12
US9062085B2 (en) 2015-06-23
AU2011301115A1 (en) 2013-05-02
JP2013538815A (ja) 2013-10-17
EA027889B1 (ru) 2017-09-29
EP2614069A1 (en) 2013-07-17
AU2011301115B2 (en) 2015-10-08
WO2012031358A1 (en) 2012-03-15
CN103189383A (zh) 2013-07-03
US20130184479A1 (en) 2013-07-18
IL225096A (en) 2016-12-29
TW201210694A (en) 2012-03-16
TWI517899B (zh) 2016-01-21
EP2614069A4 (en) 2014-02-19

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