EA201390354A1 - Хиноксалиновое соединение - Google Patents
Хиноксалиновое соединениеInfo
- Publication number
- EA201390354A1 EA201390354A1 EA201390354A EA201390354A EA201390354A1 EA 201390354 A1 EA201390354 A1 EA 201390354A1 EA 201390354 A EA201390354 A EA 201390354A EA 201390354 A EA201390354 A EA 201390354A EA 201390354 A1 EA201390354 A1 EA 201390354A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- pde9
- impaired
- inhibitory effect
- urethra
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Задача: обеспечивается соединение, которое обладает PDE9-ингибирующим действием и является полезным в качестве активного ингредиента для средства для лечения и/или профилактики нарушения функции накопления мочи, нарушения функции опорожнения и заболеваний мочевого пузыря/мочеиспускательного канала и т.п. Средства решения: авторы настоящего изобретения исследовали соединение, которое обладает PDE9-ингибирующим действием и является полезным в качестве активного ингредиента для средства для лечения и/или профилактики нарушения функции накопления мочи, нарушения функции опорожнения и заболеваний мочевого пузыря/мочеиспускательного канала и т.п., в результате было обнаружено, что имидазохиноксалиновое соединение или триазолохиноксалиновое соединение обладает PDE9-ингибирующим действием, таким образом было создано настоящее изобретение. Имидазохиноксалиновое соединение или триазолохиноксалиновое соединение по настоящему изобретению обладает PDE9-ингибирующим действием, и его можно использовать в качестве средства для профилактики и/или лечения нарушения функции накопления мочи, нарушения функции опорожнения и заболеваний мочевого пузыря/мочеиспускательного канала и т.п.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010200402 | 2010-09-07 | ||
| PCT/JP2011/070287 WO2012033101A1 (ja) | 2010-09-07 | 2011-09-06 | キノキサリン化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201390354A1 true EA201390354A1 (ru) | 2013-08-30 |
Family
ID=45810699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201390354A EA201390354A1 (ru) | 2010-09-07 | 2011-09-06 | Хиноксалиновое соединение |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8901126B2 (ru) |
| EP (1) | EP2615096B1 (ru) |
| JP (1) | JP5822080B2 (ru) |
| KR (1) | KR20130097178A (ru) |
| CN (1) | CN103097393B (ru) |
| AU (1) | AU2011299936A1 (ru) |
| BR (1) | BR112013005439A2 (ru) |
| CA (1) | CA2810659A1 (ru) |
| EA (1) | EA201390354A1 (ru) |
| ES (1) | ES2747423T3 (ru) |
| MX (1) | MX2013002579A (ru) |
| PL (1) | PL2615096T3 (ru) |
| PT (1) | PT2615096T (ru) |
| TW (1) | TW201300390A (ru) |
| WO (1) | WO2012033101A1 (ru) |
| ZA (1) | ZA201301673B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102786525B (zh) | 2012-08-08 | 2014-12-17 | 中山大学 | N-取代吡唑并[3,4-d]嘧啶酮类化合物、其制备方法及其应用 |
| WO2017046606A1 (en) * | 2015-09-18 | 2017-03-23 | Redx Pharma Plc | Antibacterial compounds |
| AR107456A1 (es) * | 2016-02-12 | 2018-05-02 | Lilly Co Eli | Inhibidor de pde1 |
| JOP20170164A1 (ar) | 2016-08-25 | 2019-01-30 | Lilly Co Eli | مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري |
| AR112457A1 (es) | 2017-08-02 | 2019-10-30 | Lilly Co Eli | Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona |
| TW201920188A (zh) | 2017-08-10 | 2019-06-01 | 美商美國禮來大藥廠 | [1,2,4]三唑衍生物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055465A (en) * | 1989-05-31 | 1991-10-08 | Berlex Laboratories, Inc. | Imidazoquinoxalinones, their aza analogs and process for their preparation |
| DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
| WO1993012113A1 (en) | 1991-12-17 | 1993-06-24 | The Upjohn Company | 3-SUBSTITUTED IMIDAZO (1,5-a) AND IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY |
| WO1993017025A1 (en) | 1992-02-19 | 1993-09-02 | The Upjohn Company | 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity |
| DK31093D0 (ru) * | 1993-03-19 | 1993-03-19 | Novo Nordisk As | |
| HUT76802A (en) | 1994-09-16 | 1997-11-28 | Novo Nordisk As | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives,process for their preparation and pharmaceutical compositions containing them |
| NZ292107A (en) | 1994-09-16 | 1999-02-25 | Novo Nordisk As | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives and medicaments |
| US6235740B1 (en) | 1997-08-25 | 2001-05-22 | Bristol-Myers Squibb Co. | Imidazoquinoxaline protein tyrosine kinase inhibitors |
| HN2002000317A (es) | 2001-11-02 | 2003-05-21 | Pfizer | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares |
| MXPA05010293A (es) | 2003-03-27 | 2005-11-17 | Pfizer Prod Inc | 4-amino[1,2,4]triazolo[4,3-a]quinoxalinas sustituidas. |
| AU2006258461B2 (en) | 2005-06-14 | 2011-08-25 | Aska Pharmaceutical Co., Ltd. | Thienopyrimidine derivative |
| EP2050739B1 (en) | 2006-08-08 | 2016-07-06 | ASKA Pharmaceutical Co., Ltd. | Quinazoline derivative |
| JPWO2008072778A1 (ja) | 2006-12-13 | 2010-04-02 | あすか製薬株式会社 | 尿路系疾患の処置剤 |
| ES2536906T3 (es) * | 2006-12-13 | 2015-05-29 | Aska Pharmaceutical Co., Ltd. | Derivado de quinoxalina |
| CN102143965A (zh) | 2008-09-08 | 2011-08-03 | 贝林格尔.英格海姆国际有限公司 | 吡唑并嘧啶酮及其在治疗中枢神经系统疾病中的用途 |
| TWI404721B (zh) | 2009-01-26 | 2013-08-11 | Pfizer | 胺基－雜環化合物 |
| EP2404922B1 (en) * | 2009-03-05 | 2016-11-09 | Astellas Pharma Inc. | Quinoxaline compounds |
-
2011
- 2011-09-06 EA EA201390354A patent/EA201390354A1/ru unknown
- 2011-09-06 ES ES11823576T patent/ES2747423T3/es active Active
- 2011-09-06 PT PT118235761T patent/PT2615096T/pt unknown
- 2011-09-06 JP JP2012532987A patent/JP5822080B2/ja active Active
- 2011-09-06 CN CN201180043069.7A patent/CN103097393B/zh active Active
- 2011-09-06 TW TW100132077A patent/TW201300390A/zh unknown
- 2011-09-06 KR KR1020137005781A patent/KR20130097178A/ko not_active Application Discontinuation
- 2011-09-06 AU AU2011299936A patent/AU2011299936A1/en not_active Abandoned
- 2011-09-06 WO PCT/JP2011/070287 patent/WO2012033101A1/ja active Application Filing
- 2011-09-06 PL PL11823576T patent/PL2615096T3/pl unknown
- 2011-09-06 EP EP11823576.1A patent/EP2615096B1/en active Active
- 2011-09-06 MX MX2013002579A patent/MX2013002579A/es active IP Right Grant
- 2011-09-06 BR BR112013005439A patent/BR112013005439A2/pt not_active IP Right Cessation
- 2011-09-06 CA CA2810659A patent/CA2810659A1/en not_active Abandoned
-
2013
- 2013-03-05 ZA ZA2013/01673A patent/ZA201301673B/en unknown
- 2013-03-07 US US13/788,770 patent/US8901126B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2615096B1 (en) | 2019-08-28 |
| WO2012033101A1 (ja) | 2012-03-15 |
| CA2810659A1 (en) | 2012-03-15 |
| EP2615096A4 (en) | 2014-03-05 |
| EP2615096A1 (en) | 2013-07-17 |
| TW201300390A (zh) | 2013-01-01 |
| AU2011299936A1 (en) | 2013-03-28 |
| PL2615096T3 (pl) | 2019-12-31 |
| KR20130097178A (ko) | 2013-09-02 |
| JP5822080B2 (ja) | 2015-11-24 |
| BR112013005439A2 (pt) | 2017-09-19 |
| MX2013002579A (es) | 2013-04-29 |
| CN103097393A (zh) | 2013-05-08 |
| US8901126B2 (en) | 2014-12-02 |
| ES2747423T3 (es) | 2020-03-10 |
| JPWO2012033101A1 (ja) | 2014-01-20 |
| PT2615096T (pt) | 2019-10-15 |
| ZA201301673B (en) | 2014-05-28 |
| CN103097393B (zh) | 2015-09-16 |
| US20130296329A1 (en) | 2013-11-07 |
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