EA201301266A1 - PHARMACEUTICAL COMPOSITION CONTAINING NALBUFIN HYDROCHLORIDE, ITS APPLICATION FOR THE TREATMENT OF MEDICAL SYNDROME OF MEDIUM AND HIGH INTENSITY AND METHOD OF OBTAINING THE PHARMACEUTICAL COMPOSITION - Google Patents
PHARMACEUTICAL COMPOSITION CONTAINING NALBUFIN HYDROCHLORIDE, ITS APPLICATION FOR THE TREATMENT OF MEDICAL SYNDROME OF MEDIUM AND HIGH INTENSITY AND METHOD OF OBTAINING THE PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- EA201301266A1 EA201301266A1 EA201301266A EA201301266A EA201301266A1 EA 201301266 A1 EA201301266 A1 EA 201301266A1 EA 201301266 A EA201301266 A EA 201301266A EA 201301266 A EA201301266 A EA 201301266A EA 201301266 A1 EA201301266 A1 EA 201301266A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- high intensity
- pharmaceutical composition
- moderate
- poloxamer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относится к области медицины и химико-фармацевтической промышленности, конкретно к созданию, производству и применению лекарственного средства для лечения (купирования) болевого синдрома средней и высокой интенсивности в разных областях медицины, в частности в онкологии. Задача данного изобретения заключается в создании новых фармацевтических композиций в форме ректальных суппозиториев, содержащих налбуфин или его соль на разных суппозиторных основах, предназначенных для лечения (купирования) приступов боли от средней до высокой интенсивности, обладающих эффективным и пролонгированным анальгезирующим действием при отсутствии послабляющего эффекта, а также в разработке способов получения этих композиций. Для решения поставленной задачи предлагается применение соли налбуфина в виде суппозиторий на гидрофильной эмульсионной основе для лечения болевого синдрома умеренной и высокой интенсивности. Фармацевтическая композиция для лечения болевого синдрома умеренной и высокой интенсивности в форме суппозиториев включает в качестве действующего вещества налбуфина гидрохлорид и суппозиторную основу. В качестве суппозиторной основы композиция содержит гидрофильную эмульсионную основу, включающую формообразователи, полоксамер, наполнитель, эмульгатор, пропиленгликоль и полиэтиленоксид 400 в качестве растворителя. При этом в качестве формообразователей композиция предпочтительно содержит полиэтиленоксид 4000 и полиэтиленоксид 1500, а полоксамер представляет собой полоксамер 188. При этом в качестве наполнителя композиция предпочтительно содержит твердый жир. Кроме того, в качестве эмульгатораThe invention relates to the field of medicine and the pharmaceutical industry, specifically to the creation, production and use of a medicament for the treatment (relief) of moderate and high intensity pain in various fields of medicine, in particular in oncology. The objective of this invention is to create new pharmaceutical compositions in the form of rectal suppositories containing nalbuphine or its salt on different suppository bases, intended for the treatment (relief) of moderate to high intensity pain attacks with an effective and prolonged analgesic effect in the absence of a laxative effect, and also in the development of methods for producing these compositions. To solve this problem, the use of nalbuphine salt in the form of suppositories on a hydrophilic emulsion base for the treatment of moderate and high intensity pain syndrome is proposed. The pharmaceutical composition for the treatment of moderate to high intensity pain in the form of suppositories includes nalbuphine hydrochloride and a suppository base as the active ingredient. As a suppository base, the composition contains a hydrophilic emulsion base, including formers, poloxamer, filler, emulsifier, propylene glycol and polyethylene oxide 400 as a solvent. Moreover, the composition preferably comprises polyethylene oxide 4000 and polyethylene oxide 1500 as forming agents, and the poloxamer is poloxamer 188. Moreover, the composition preferably contains solid fat as a filler. In addition, as an emulsifier
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2012150118/15A RU2513514C1 (en) | 2012-11-23 | 2012-11-23 | Pharmaceutical composition containing nalbuphine hydrochloride, using it for treating moderate to severe pain syndrome |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201301266A1 true EA201301266A1 (en) | 2014-05-30 |
EA201301266A8 EA201301266A8 (en) | 2015-07-30 |
EA023024B1 EA023024B1 (en) | 2016-04-29 |
Family
ID=50480928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201301266A EA023024B1 (en) | 2012-11-23 | 2013-11-19 | Pharmaceutical composition containing nalbuphine hydrochloride, use thereof to treat moderate to severe pain and method for producing said pharmaceutical composition |
Country Status (5)
Country | Link |
---|---|
EA (1) | EA023024B1 (en) |
MD (1) | MD4451C1 (en) |
RU (1) | RU2513514C1 (en) |
UA (1) | UA108307C2 (en) |
WO (1) | WO2014081343A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
ES2562878T3 (en) | 2007-05-25 | 2016-03-08 | Indivior Uk Limited | Sustained release formulations of risperidone compounds |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
RU2646495C2 (en) * | 2015-12-28 | 2018-03-05 | Общество с ограниченной ответственностью "Научно-техническая производственная фирма "Анта-Медикал" | Pharmaceutical compositions as rectal suppositories containing nefopam hydrochloride (versions), their application for treatment of acute and chronic pain syndrome and methods for production |
RU2661617C1 (en) * | 2017-11-23 | 2018-07-17 | Общество с ограниченной ответственностью "Научно-техническая производственная фирма "Анта-Медикал" | Nephopam suppositories for the treatment of acute and chronic pain syndrome on a hydrophilic emulsion based and method for their preparation |
RU2661618C1 (en) * | 2017-11-23 | 2018-07-17 | Общество с ограниченной ответственностью "Научно-техническая производственная фирма "Анта-Медикал" | Nephopam suppositories for the treatment of acute and chronic pain syndrome on a lipophilic basis and the method for their preparation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7201920B2 (en) * | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
DE102004021992A1 (en) * | 2004-05-03 | 2005-11-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Topical preparation containing ambroxol |
RU2356535C2 (en) * | 2007-07-23 | 2009-05-27 | Закрытое Акционерное Общество "Биокад" | Synergistic suppositories for infectious gynecopathies treatment (versions) |
RU2363446C1 (en) * | 2008-02-26 | 2009-08-10 | Евгений Федорович Кира | Suppositories for treating gynaecological and urological diseases based on dead sea dirt (versions) |
RU2479305C2 (en) * | 2010-12-06 | 2013-04-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Pharmaceutical composition for treating infectious inflammatory diseases and method for preparing it |
-
2012
- 2012-11-23 RU RU2012150118/15A patent/RU2513514C1/en active
-
2013
- 2013-11-18 WO PCT/RU2013/001031 patent/WO2014081343A2/en active Application Filing
- 2013-11-18 MD MDA20150057A patent/MD4451C1/en not_active IP Right Cessation
- 2013-11-19 EA EA201301266A patent/EA023024B1/en not_active IP Right Cessation
- 2013-11-21 UA UAA201313546A patent/UA108307C2/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2513514C1 (en) | 2014-04-20 |
WO2014081343A2 (en) | 2014-05-30 |
MD4451B1 (en) | 2016-12-31 |
MD20150057A2 (en) | 2015-09-30 |
EA201301266A8 (en) | 2015-07-30 |
UA108307C2 (en) | 2015-04-10 |
MD4451C1 (en) | 2017-07-31 |
WO2014081343A3 (en) | 2014-08-28 |
EA023024B1 (en) | 2016-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |