EA201290905A1 - Бензазепиновое соединение - Google Patents
Бензазепиновое соединениеInfo
- Publication number
- EA201290905A1 EA201290905A1 EA201290905A EA201290905A EA201290905A1 EA 201290905 A1 EA201290905 A1 EA 201290905A1 EA 201290905 A EA201290905 A EA 201290905A EA 201290905 A EA201290905 A EA 201290905A EA 201290905 A1 EA201290905 A1 EA 201290905A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- urinary incontinence
- incontinence
- obesity
- treatment
- receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Предложено соединение, которое используется в качестве средства для лечения или профилактики заболеваний, связанных с рецептором 5-HT, в частности недержания, такого как стрессовое недержание мочи, ургентное недержание мочи, смешанное недержание мочи, половой дисфункции, такой как синдром эректильной дисфункции, ожирения и т.п. Проведены исследования соединений, имеющих активность агониста рецептора 5-HT, которые являются перспективными в качестве активного ингредиента фармацевтической композиции для лечения или профилактики недержания, такого как стрессовое недержание мочи, ургентное недержание мочи, смешанное недержание мочи и т.п., половой дисфункции, такой как синдром эректильной дисфункции, ожирения и т.п., и обнаружено, что бензазепиновые соединения по настоящему изобретению обладают превосходной активностью агониста рецептора 5-HT, осуществляя тем самым настоящее изобретение. То есть бензазепиновые соединения по настоящему изобретению обладают активностью агониста рецептора 5-HTи могут быть использованы в качестве средства для лечения или профилактики заболеваний, связанных с рецептором 5-HT, в частности недержания, такого как стрессовое недержание мочи, ургентное недержание мочи, смешанное недержание мочи и т.п., половой дисфункции, такой как синдром эректильной дисфункции, ожирения и т.п.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31313310P | 2010-03-12 | 2010-03-12 | |
| PCT/JP2011/055759 WO2011111817A1 (ja) | 2010-03-12 | 2011-03-11 | ベンゾアゼピン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201290905A1 true EA201290905A1 (ru) | 2013-03-29 |
| EA023039B1 EA023039B1 (ru) | 2016-04-29 |
Family
ID=44563615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201290905A EA023039B1 (ru) | 2010-03-12 | 2011-03-11 | Бензазепиновое соединение, фармацевтическая композиция, включающая его, и его применение |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20110269744A1 (ru) |
| EP (1) | EP2546255B1 (ru) |
| JP (1) | JP5747910B2 (ru) |
| KR (1) | KR101769642B1 (ru) |
| CN (1) | CN102869665B (ru) |
| AU (1) | AU2011225108C1 (ru) |
| BR (1) | BR112012022915B1 (ru) |
| CA (1) | CA2792918C (ru) |
| CY (1) | CY1118268T1 (ru) |
| DK (1) | DK2546255T3 (ru) |
| EA (1) | EA023039B1 (ru) |
| ES (1) | ES2605466T3 (ru) |
| HR (1) | HRP20161529T1 (ru) |
| HU (1) | HUE031082T2 (ru) |
| IL (1) | IL221737A (ru) |
| LT (1) | LT2546255T (ru) |
| MX (1) | MX338130B (ru) |
| PL (1) | PL2546255T3 (ru) |
| PT (1) | PT2546255T (ru) |
| RS (1) | RS55362B1 (ru) |
| SI (1) | SI2546255T1 (ru) |
| TW (1) | TWI495640B (ru) |
| UA (1) | UA110479C2 (ru) |
| WO (1) | WO2011111817A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| GB2520266A (en) * | 2013-11-13 | 2015-05-20 | Ibm | Cursor-Based Character input interface |
| WO2016044463A2 (en) * | 2014-09-17 | 2016-03-24 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| US10452679B2 (en) * | 2016-09-30 | 2019-10-22 | Google Llc | Systems and methods for context-sensitive data annotation and annotation visualization |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002074746A1 (ja) * | 2001-03-16 | 2004-07-08 | 山之内製薬株式会社 | ベンゾアゼピン誘導体 |
| US6953787B2 (en) * | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| CN1805938B (zh) | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
| WO2005042491A1 (en) | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| WO2005042490A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| EA011011B1 (ru) * | 2004-02-25 | 2008-12-30 | Эли Лилли Энд Компани | 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT |
| GB0412314D0 (en) | 2004-06-02 | 2004-07-07 | Glaxo Group Ltd | Compounds |
| TW201031661A (en) | 2009-02-17 | 2010-09-01 | Targacept Inc | Fused benzazepines as neuronal nicotinic acetylcholine receptor ligands |
-
2011
- 2011-03-09 US US13/044,080 patent/US20110269744A1/en not_active Abandoned
- 2011-03-11 CN CN201180013703.2A patent/CN102869665B/zh active Active
- 2011-03-11 MX MX2012010570A patent/MX338130B/es active IP Right Grant
- 2011-03-11 CA CA2792918A patent/CA2792918C/en active Active
- 2011-03-11 RS RS20161038A patent/RS55362B1/sr unknown
- 2011-03-11 BR BR112012022915-0A patent/BR112012022915B1/pt active IP Right Grant
- 2011-03-11 TW TW100108310A patent/TWI495640B/zh not_active IP Right Cessation
- 2011-03-11 PT PT117534750T patent/PT2546255T/pt unknown
- 2011-03-11 DK DK11753475.0T patent/DK2546255T3/en active
- 2011-03-11 KR KR1020127026576A patent/KR101769642B1/ko active IP Right Grant
- 2011-03-11 SI SI201131007A patent/SI2546255T1/sl unknown
- 2011-03-11 JP JP2012504533A patent/JP5747910B2/ja not_active Expired - Fee Related
- 2011-03-11 AU AU2011225108A patent/AU2011225108C1/en not_active Ceased
- 2011-03-11 EP EP11753475.0A patent/EP2546255B1/en active Active
- 2011-03-11 LT LTEP11753475.0T patent/LT2546255T/lt unknown
- 2011-03-11 EA EA201290905A patent/EA023039B1/ru not_active IP Right Cessation
- 2011-03-11 PL PL11753475T patent/PL2546255T3/pl unknown
- 2011-03-11 ES ES11753475.0T patent/ES2605466T3/es active Active
- 2011-03-11 US US13/583,410 patent/US20130012496A1/en not_active Abandoned
- 2011-03-11 HU HUE11753475A patent/HUE031082T2/en unknown
- 2011-03-11 WO PCT/JP2011/055759 patent/WO2011111817A1/ja active Application Filing
- 2011-11-03 UA UAA201211777A patent/UA110479C2/ru unknown
-
2012
- 2012-09-02 IL IL221737A patent/IL221737A/en not_active IP Right Cessation
- 2012-09-13 US US13/613,948 patent/US9108977B2/en active Active
-
2015
- 2015-07-13 US US14/797,277 patent/US9598434B2/en active Active
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2016
- 2016-11-21 HR HRP20161529TT patent/HRP20161529T1/hr unknown
- 2016-11-29 CY CY20161101235T patent/CY1118268T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |