EA201200716A1 - METHOD FOR OBTAINING CRYSTALLINE FORMS A AND B IN ILAPRAZOL AND METHOD FOR TURNING THE INDICATED CRYSTALLINE FORMS - Google Patents
METHOD FOR OBTAINING CRYSTALLINE FORMS A AND B IN ILAPRAZOL AND METHOD FOR TURNING THE INDICATED CRYSTALLINE FORMSInfo
- Publication number
- EA201200716A1 EA201200716A1 EA201200716A EA201200716A EA201200716A1 EA 201200716 A1 EA201200716 A1 EA 201200716A1 EA 201200716 A EA201200716 A EA 201200716A EA 201200716 A EA201200716 A EA 201200716A EA 201200716 A1 EA201200716 A1 EA 201200716A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- crystalline forms
- obtaining
- ilaprazole
- ilaprazol
- turning
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Представляются новые способы получения кристаллических форм А и В илапразола и превращения указанных кристаллических форм. Указанные новые способы включают способ получения кристаллической формы А высокой чистоты путём получения неорганической соли илапразола или её гидрата и последующей нейтрализации полученной неорганической соли илапразола или её гидрата с помощью кислоты в органическом растворителе (индивидуальном растворителе или в смеси растворителей); способ получения кристаллической формы В высокой чистоты путём удаления примесей из илапразола с использованием органического растворителя (индивидуального растворителя или смеси растворителей); и способ превращения кристаллической формы А в кристаллическую форму В или кристаллической формы В в кристаллическую форму А.New methods of obtaining crystalline forms A and B of ilaprazole and converting said crystalline forms are presented. These new methods include a method for obtaining high purity crystalline form A by obtaining an inorganic salt of ilaprazole or its hydrate and then neutralizing the resulting inorganic salt of ilaprazole or its hydrate with an acid in an organic solvent (an individual solvent or in a mixture of solvents); a method of obtaining a crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (an individual solvent or a mixture of solvents); and a method of converting crystal form A to crystal form B or crystal form B to crystal form A.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020090121209A KR101144600B1 (en) | 2009-12-08 | 2009-12-08 | Process for Preparing and Conversion of Ilaprazole Crystalline Form A, B |
PCT/KR2010/008767 WO2011071314A2 (en) | 2009-12-08 | 2010-12-08 | Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201200716A1 true EA201200716A1 (en) | 2012-10-30 |
EA019058B1 EA019058B1 (en) | 2013-12-30 |
Family
ID=44146052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201200716A EA019058B1 (en) | 2009-12-08 | 2010-12-08 | Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms |
Country Status (7)
Country | Link |
---|---|
KR (1) | KR101144600B1 (en) |
BR (1) | BR112012012212A2 (en) |
CO (1) | CO6541539A2 (en) |
EA (1) | EA019058B1 (en) |
IN (1) | IN2012DN03176A (en) |
UA (1) | UA102787C2 (en) |
WO (1) | WO2011071314A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103204842B (en) * | 2012-01-13 | 2014-10-15 | 丽珠医药集团股份有限公司 | Crystalline Ilaprazole sodium hydrate and preparation method thereof |
CN103204843B (en) * | 2012-01-13 | 2014-12-31 | 丽珠医药集团股份有限公司 | Crystalline Ilaprazole sodium ethylate and preparation method thereof |
WO2013114232A1 (en) | 2012-02-02 | 2013-08-08 | Lupin Limited | Process for preparation of crystalline form l of ilaprazole |
CN102746276B (en) * | 2012-06-21 | 2014-07-02 | 丽珠医药集团股份有限公司 | Ilaprazole sodium crystal form and preparation method thereof |
CN102746277B (en) * | 2012-06-21 | 2014-05-14 | 丽珠医药集团股份有限公司 | Crystal-form ilaprazole sodium and preparation method thereof |
CN102746275B (en) * | 2012-06-21 | 2014-07-16 | 丽珠医药集团股份有限公司 | Crystallization-type ilaprazole sodium and preparation method thereof |
CN105461692A (en) * | 2014-09-04 | 2016-04-06 | 江苏奥赛康药业股份有限公司 | Ilaprazole sodium compound and pharmaceutical composition thereof |
CN115403560A (en) * | 2017-11-06 | 2022-11-29 | 丽珠医药集团股份有限公司 | Ilaprazole magnesium crystal form and preparation method thereof |
KR102027388B1 (en) * | 2017-11-15 | 2019-10-01 | 주식회사 다산제약 | Process for preparing high purity ilaprazole crystalline form B |
CN111187255B (en) * | 2020-01-13 | 2021-07-20 | 丽珠医药集团股份有限公司 | Preparation method of dextro-ilaprazole potassium salt and preparation method of dextro-ilaprazole |
KR20220065235A (en) | 2020-11-13 | 2022-05-20 | 주식회사 파마코스텍 | Process for the crystalline form of Ilaprazole |
KR102250509B1 (en) * | 2020-12-09 | 2021-05-11 | 유니셀랩 주식회사 | Novel co-crystal of ilaprazole/xylitol |
KR20210019469A (en) | 2021-02-02 | 2021-02-22 | 주식회사 파마코스텍 | Crystalline form of Ilaprazole sodium and its new process |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ577129A (en) * | 2006-12-29 | 2012-02-24 | Il Yang Pahrmaceutical Company Ltd | Solid state crystalline form a of racemic ilaprazole |
WO2008083319A1 (en) * | 2006-12-29 | 2008-07-10 | Il Yang Pharmaceutical Company, Ltd. | Solid state forms of enantiopure ilaprazole |
-
2009
- 2009-12-08 KR KR1020090121209A patent/KR101144600B1/en active IP Right Grant
-
2010
- 2010-12-08 UA UAA201207006A patent/UA102787C2/en unknown
- 2010-12-08 BR BR112012012212A patent/BR112012012212A2/en not_active Application Discontinuation
- 2010-12-08 EA EA201200716A patent/EA019058B1/en not_active IP Right Cessation
- 2010-12-08 IN IN3176DEN2012 patent/IN2012DN03176A/en unknown
- 2010-12-08 WO PCT/KR2010/008767 patent/WO2011071314A2/en active Application Filing
-
2012
- 2012-06-08 CO CO12097489A patent/CO6541539A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
CO6541539A2 (en) | 2012-10-16 |
UA102787C2 (en) | 2013-08-12 |
BR112012012212A2 (en) | 2015-09-08 |
IN2012DN03176A (en) | 2015-09-25 |
KR101144600B1 (en) | 2012-05-16 |
WO2011071314A2 (en) | 2011-06-16 |
WO2011071314A3 (en) | 2011-11-10 |
EA019058B1 (en) | 2013-12-30 |
KR20110064545A (en) | 2011-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201200716A1 (en) | METHOD FOR OBTAINING CRYSTALLINE FORMS A AND B IN ILAPRAZOL AND METHOD FOR TURNING THE INDICATED CRYSTALLINE FORMS | |
EA200801833A1 (en) | METHODS OF OBTAINING CRYSTALLINE FORMS OF DULOXETHINE HYDROCHLORIDE | |
EA201491146A1 (en) | METHOD FOR EXTRACTING CARBONIC ACID FROM AQUEOUS SOLUTION | |
DK2453739T3 (en) | PROCEDURE FOR PREPARING A WATER SUSPENSION OF AN ORGANIC PESTICID COMPOUND | |
EA201291225A1 (en) | IMPROVED WAYS TO GET SQUAL | |
EA201000147A1 (en) | METHOD OF ISOLATION AND CLEANING OF MONTELUKAST | |
EA201690897A1 (en) | COMPOSITIONS OF HYBRID SOLVENTS FOR FULL REMOVAL OF ORGANIC SULFUR AND FULL REMOVAL OF ACID GAS | |
EA201070811A1 (en) | METHODS AND COMPOSITIONS FOR REMOVAL OF IMPURITIES AND WATER FROM THE BAYER METHOD | |
RU2017102893A (en) | METHOD FOR SEPARATING TRITIUM WATER FROM LIGHT WATER | |
PL2537840T3 (en) | Process to produce valerolactone from levulinic acid | |
EA201270283A1 (en) | METHOD OF OBTAINING SEVOPORATOV AND COMPLEXES CONTAINING VORIKONOZOL AND CYCLODEXTRIN | |
MY196287A (en) | Methods For Purifying 5-(Halomethyl)Furfural | |
AR081659A1 (en) | PROCEDURE FOR OBTAINING THE CRYSTAL FORM II OF FEBUXOSTAT | |
EA201592026A1 (en) | METHOD FOR ISOLATION OF LEVULINIC ACID FROM BIOMASS HYDROLYSIS PRODUCT | |
WO2015068159A3 (en) | Process for the preparation of n-iodoamides | |
MX338556B (en) | Methods of isolating 4-chloro-2-fluoro-3-substituted-phenylboroni c acids. | |
EA201590657A1 (en) | Method of producing high-purity potassium salt of azilsarethan medoxomil | |
EA201170346A1 (en) | METHOD FOR PREPARING CRYSTALLINE METAL ALUMOPHOSPHATE (MeAPO) MOLECULAR SITE FROM AMORPHOUS MATERIALS | |
DK2265551T3 (en) | Process for removing organic constituents from a mixture of organic constituents and water and a device for carrying out such a process | |
EA201290511A1 (en) | METHODS AND COMPOSITIONS FOR REMOVAL OF IMPURITIES FROM ORGANIC SALT LOADED WITH IMPURITIES | |
FI20106311A (en) | A method for recovering an organic acid from a dilute aqueous solution | |
BR112016024977A2 (en) | process for the preparation of imidaclopride polymorphs | |
GB201120138D0 (en) | Novel process | |
AR094240A1 (en) | PROCESS TO PRODUCE PIRAZOL COMPOSITE CRYSTAL | |
IN2013CH00569A (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |