EA200971019A1 - METHODS OF OBTAINING (R) -2-METHILPYRROLIDINE AND (S) -2-METHILPYRROLIDINE AND THEIR SALTS OF WINE ACID - Google Patents

METHODS OF OBTAINING (R) -2-METHILPYRROLIDINE AND (S) -2-METHILPYRROLIDINE AND THEIR SALTS OF WINE ACID

Info

Publication number
EA200971019A1
EA200971019A1 EA200971019A EA200971019A EA200971019A1 EA 200971019 A1 EA200971019 A1 EA 200971019A1 EA 200971019 A EA200971019 A EA 200971019A EA 200971019 A EA200971019 A EA 200971019A EA 200971019 A1 EA200971019 A1 EA 200971019A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methilpyrrolidine
salts
obtaining
methods
wine acid
Prior art date
Application number
EA200971019A
Other languages
Russian (ru)
Other versions
EA019031B1 (en
Inventor
Майкл Кристи
Джозеф Дж. Петрейтис
Original Assignee
Сефалон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сефалон, Инк. filed Critical Сефалон, Инк.
Publication of EA200971019A1 publication Critical patent/EA200971019A1/en
Publication of EA019031B1 publication Critical patent/EA019031B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение относится к быстрому, безопасному, недорогому и крупномасштабному способу получения (R)- или (S)-2-метилпирролидина из 2-метилпирролина, в котором не требуется выделение синтетических промежуточных соединений.The present invention relates to a fast, safe, inexpensive and large-scale process for the preparation of (R) - or (S) -2-methylpyrrolidine from 2-methylpyrroline, which does not require isolation of synthetic intermediates.

EA200971019A 2007-05-03 2008-05-02 Process for preparing 6-{4-[3-((r)-2-methylpyrrolidine-1-yl)propoxy]phenyl}-2h-piridazin-3-one and pharmaceutically acceptable salt thereof EA019031B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92735607P 2007-05-03 2007-05-03
PCT/US2008/005702 WO2008137087A1 (en) 2007-05-03 2008-05-02 Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof

Publications (2)

Publication Number Publication Date
EA200971019A1 true EA200971019A1 (en) 2010-04-30
EA019031B1 EA019031B1 (en) 2013-12-30

Family

ID=39688886

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200971019A EA019031B1 (en) 2007-05-03 2008-05-02 Process for preparing 6-{4-[3-((r)-2-methylpyrrolidine-1-yl)propoxy]phenyl}-2h-piridazin-3-one and pharmaceutically acceptable salt thereof

Country Status (14)

Country Link
EP (1) EP2152669A1 (en)
JP (1) JP5698887B2 (en)
KR (1) KR20100017565A (en)
CN (1) CN101679237A (en)
AU (1) AU2008248168B2 (en)
BR (1) BRPI0810330A2 (en)
CA (1) CA2686033A1 (en)
EA (1) EA019031B1 (en)
IL (1) IL201627A (en)
MX (1) MX2009011787A (en)
NZ (1) NZ580948A (en)
UA (1) UA99913C2 (en)
WO (1) WO2008137087A1 (en)
ZA (1) ZA200907643B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95644C2 (en) 2006-07-25 2011-08-25 Сефалон, Инк. Pyridizinone derivative, pharmaceutical composition and treatment method
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
CA2712885A1 (en) * 2008-01-30 2009-08-06 Cephalon, Inc. Substituted pyridazine derivatives which have histamine h3 antagonist activity
JP6849594B2 (en) * 2014-12-23 2021-03-24 セファロン、インク． Method for Preparing Condensed Bicyclic 2,4-diaminopyrimidine Derivatives

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329974A1 (en) 1983-08-19 1985-02-28 Bayer Ag, 5090 Leverkusen MANUFACTURE OF HYDRATED NITRILE RUBBER
DE3433392A1 (en) 1984-09-12 1986-03-20 Bayer Ag, 5090 Leverkusen HYDROGENATION OF UNSATURATED POLYMER WITH NITRILE GROUPS
FR2714849B1 (en) 1994-01-13 1996-04-05 Inst Francais Du Petrole Process for the preparation of a hydrogenation catalyst soluble in the organic liquid phase.
DE4403479A1 (en) 1994-02-04 1995-08-10 Basf Ag Process for the preparation of hydroxylammonium salts
WO2004024707A2 (en) * 2002-09-16 2004-03-25 Abbott Laboratories Process for preparing amine type substituted benzofurans
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
US8110519B2 (en) 2004-03-08 2012-02-07 Japan Science & Technology Agency Polymer-supported metal cluster composition
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
RU2387638C2 (en) 2004-06-02 2010-04-27 Ф.Хофманн-ля Рош АГ Naphthalene derivatives suitable for use as ligands of histamine 3 receptors
CN101111480A (en) 2004-12-01 2008-01-23 万有制药株式会社 Substituted pyridone derivative
CA2592353A1 (en) 2004-12-17 2006-06-22 Janssen Pharmaceutica, N.V. Tetrahydroisoquinoline compounds for treatment of cns disorders
CN101107231A (en) 2005-01-21 2008-01-16 先灵公司 Imidazole and benzimidazole derivatives useful as histamine H3 antagonists
EP1866293A1 (en) 2005-03-31 2007-12-19 UCB Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
GB0514812D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
TW200804274A (en) 2005-10-27 2008-01-16 Ucb Sa Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
CA2641441A1 (en) 2006-02-09 2007-08-23 Athersys, Inc. Pyrazoles for the treatment of obesity and other cns disorders
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
WO2007105053A2 (en) 2006-03-13 2007-09-20 Pfizer Products Inc. Tetralines antagonists of the h-3 receptor
WO2008005338A1 (en) 2006-06-29 2008-01-10 Arena Pharmaceuticals, Inc. Modulators of the histamine h3-receptor useful for the treatment of disorders related thereto
UA95644C2 (en) 2006-07-25 2011-08-25 Сефалон, Инк. Pyridizinone derivative, pharmaceutical composition and treatment method

Also Published As

Publication number Publication date
JP5698887B2 (en) 2015-04-08
AU2008248168A1 (en) 2008-11-13
EA019031B1 (en) 2013-12-30
ZA200907643B (en) 2014-03-26
KR20100017565A (en) 2010-02-16
EP2152669A1 (en) 2010-02-17
CA2686033A1 (en) 2008-11-13
IL201627A (en) 2014-06-30
BRPI0810330A2 (en) 2014-10-14
UA99913C2 (en) 2012-10-25
JP2010526142A (en) 2010-07-29
NZ580948A (en) 2011-04-29
MX2009011787A (en) 2009-11-13
IL201627A0 (en) 2010-05-31
CN101679237A (en) 2010-03-24
WO2008137087A1 (en) 2008-11-13
AU2008248168B2 (en) 2013-03-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU