EA201170563A1 - Метиленамины тиено[2,3-d]пиримидина и их применение в качестве антагонистов рецепторов a2a аденозина - Google Patents

Метиленамины тиено[2,3-d]пиримидина и их применение в качестве антагонистов рецепторов a2a аденозина

Info

Publication number
EA201170563A1
EA201170563A1 EA201170563A EA201170563A EA201170563A1 EA 201170563 A1 EA201170563 A1 EA 201170563A1 EA 201170563 A EA201170563 A EA 201170563A EA 201170563 A EA201170563 A EA 201170563A EA 201170563 A1 EA201170563 A1 EA 201170563A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidine
application
thieno
methylenamines
antagonists
Prior art date
Application number
EA201170563A
Other languages
English (en)
Inventor
Дж. Кент Барбей
Деврадж Чакраварти
Брайан Кристофер Шук
Айхуа Ван
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201170563A1 publication Critical patent/EA201170563A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к новому тиено[2,3-d]пиримидину формулы А, а также к его возможному терапевтическому и профилактическому использованию, где Rи Rопределены в тексте заявки. Расстройства, для терапии и(или) профилактики которых может использоваться новое соединение, включают болезнь Паркинсона.
EA201170563A 2008-10-13 2009-09-29 Метиленамины тиено[2,3-d]пиримидина и их применение в качестве антагонистов рецепторов a2a аденозина EA201170563A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10478108P 2008-10-13 2008-10-13
US12/479,158 US20100093702A1 (en) 2008-10-13 2009-06-05 METHYLENE AMINES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
PCT/US2009/058705 WO2010045006A1 (en) 2008-10-13 2009-09-29 Methylene amines of thieno [2,3-d] pyrimidine and their use as adenosine a2a receptor antagonists

Publications (1)

Publication Number Publication Date
EA201170563A1 true EA201170563A1 (ru) 2011-10-31

Family

ID=42099433

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170563A EA201170563A1 (ru) 2008-10-13 2009-09-29 Метиленамины тиено[2,3-d]пиримидина и их применение в качестве антагонистов рецепторов a2a аденозина

Country Status (17)

Country Link
US (1) US20100093702A1 (ru)
EP (1) EP2350092A1 (ru)
JP (1) JP2012505264A (ru)
KR (1) KR20110071109A (ru)
CN (1) CN102245614A (ru)
AU (1) AU2009303694A1 (ru)
BR (1) BRPI0920217A2 (ru)
CA (1) CA2740406A1 (ru)
CL (1) CL2011000832A1 (ru)
CO (1) CO6321169A2 (ru)
EA (1) EA201170563A1 (ru)
EC (1) ECSP11010977A (ru)
IL (1) IL212173A0 (ru)
MX (1) MX2011003962A (ru)
PE (1) PE20110423A1 (ru)
WO (1) WO2010045006A1 (ru)
ZA (1) ZA201103489B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011022191A1 (en) 2009-08-21 2011-02-24 The Trustees Of The University Of Pennsylvania Adamantane analogs
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
US9884832B2 (en) * 2011-12-06 2018-02-06 The Trustees Of The University Of Pennsylvania Inhibitors targeting drug-resistant influenza A
AU2016378723B2 (en) 2015-12-22 2021-09-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
WO2018137036A1 (en) 2017-01-26 2018-08-02 The Royal Institution For The Advancement Of Learning / Mcgill University Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
JP7514005B2 (ja) 2017-06-21 2024-07-10 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1099150C (zh) * 1996-02-16 2003-01-15 阿苏拉布股份有限公司 包含利用光生伏打电池为蓄电池充电的充电装置的钟表
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
NZ522326A (en) * 2000-05-26 2006-03-31 Schering Corp Adenosine A2A receptor antagonists
GB0100620D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
ES2217956B1 (es) * 2003-01-23 2006-04-01 Almirall Prodesfarma, S.A. Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.

Also Published As

Publication number Publication date
CA2740406A1 (en) 2010-04-22
KR20110071109A (ko) 2011-06-28
ECSP11010977A (es) 2011-05-31
MX2011003962A (es) 2011-05-03
EP2350092A1 (en) 2011-08-03
WO2010045006A1 (en) 2010-04-22
AU2009303694A1 (en) 2010-04-22
CO6321169A2 (es) 2011-09-20
PE20110423A1 (es) 2011-07-08
IL212173A0 (en) 2011-06-30
BRPI0920217A2 (pt) 2015-12-22
CL2011000832A1 (es) 2011-07-15
CN102245614A (zh) 2011-11-16
JP2012505264A (ja) 2012-03-01
ZA201103489B (en) 2012-11-28
US20100093702A1 (en) 2010-04-15

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