EA201101458A1 - Лекарственная форма для внутривенного вливания, содержащая водорастворимые сокристаллы ацетилсалициловой кислоты и теанина - Google Patents

Лекарственная форма для внутривенного вливания, содержащая водорастворимые сокристаллы ацетилсалициловой кислоты и теанина

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Publication number
EA201101458A1
EA201101458A1 EA201101458A EA201101458A EA201101458A1 EA 201101458 A1 EA201101458 A1 EA 201101458A1 EA 201101458 A EA201101458 A EA 201101458A EA 201101458 A EA201101458 A EA 201101458A EA 201101458 A1 EA201101458 A1 EA 201101458A1
Authority
EA
Eurasian Patent Office
Prior art keywords
theanine
soluble
acetylsalicylic acid
acid
acetylalylicylic
Prior art date
Application number
EA201101458A
Other languages
English (en)
Other versions
EA022058B1 (ru
Inventor
Гарри Г. Бриттаин
Филип В. Фелисе
Original Assignee
Солуприн Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Солуприн Фармасьютикалс, Инк. filed Critical Солуприн Фармасьютикалс, Инк.
Publication of EA201101458A1 publication Critical patent/EA201101458A1/ru
Publication of EA022058B1 publication Critical patent/EA022058B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Водорастворимая композиция сокристаллов аспирин-теанин, включающая в себя количество ацетилсалициловой кислоты и часть энантиомера теанина, соединенного с частью ацетилсалициловой кислоты. Композиция может быть создана с помощью способа, включающего этапы: (i) приготовление части ацетилсалициловой кислоты; (ii) добавление части энантиомера теанина к части ацетилсалициловой кислоты для образования смеси, состоящей из части ацетилсалициловой кислоты и энантиомера теанина; (iii) смачивание смеси и (iv) измельчение указанной смеси в течение времени, достаточного для получения сухой кристаллической массы. Водорастворимая сокристаллическая композиция подходит для внутривенного введения, предпочтительно человеку.
EA201101458A 2009-05-08 2009-06-23 Способ создания водорастворимых сокристаллов ацетилсалициловой кислоты и теанина EA022058B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/437,735 US8173625B2 (en) 2009-05-08 2009-05-08 Intravenous formulation with water-soluble cocrystals of acetylsalicylic acid and theanine
PCT/US2009/048275 WO2010128977A1 (en) 2009-05-08 2009-06-23 Intravenous formulation with water-soluble cocrystals of acetylsalicylic acid and theanine

Publications (2)

Publication Number Publication Date
EA201101458A1 true EA201101458A1 (ru) 2012-05-30
EA022058B1 EA022058B1 (ru) 2015-10-30

Family

ID=43050309

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101458A EA022058B1 (ru) 2009-05-08 2009-06-23 Способ создания водорастворимых сокристаллов ацетилсалициловой кислоты и теанина

Country Status (13)

Country Link
US (11) US8173625B2 (ru)
EP (1) EP2427196B1 (ru)
JP (1) JP5568127B2 (ru)
KR (1) KR101603368B1 (ru)
CN (1) CN102421438B (ru)
CA (1) CA2760555C (ru)
EA (1) EA022058B1 (ru)
HK (1) HK1164162A1 (ru)
IL (1) IL215922A (ru)
MX (1) MX2011011871A (ru)
NZ (1) NZ596200A (ru)
SG (1) SG175921A1 (ru)
WO (1) WO2010128977A1 (ru)

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RU2539350C1 (ru) * 2013-12-24 2015-01-20 Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской академии наук (ИХР РАН) Сокристаллическая форма 2-гидроксибензамида с салициловой кислотой

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US8173625B2 (en) * 2009-05-08 2012-05-08 Theaprin Pharmaceuticals Inc. Intravenous formulation with water-soluble cocrystals of acetylsalicylic acid and theanine
ITMI20120586A1 (it) 2012-04-11 2013-10-12 Milano Politecnico Co-cristalli di 3-iodiopropinil butilcarbammato
GB201311984D0 (en) * 2013-07-04 2013-08-21 Univ Cardiff Methods and compounds for preventing or treating osteoarthritis
US9738622B2 (en) 2014-05-27 2017-08-22 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
US10508096B2 (en) 2014-05-27 2019-12-17 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
US9896429B2 (en) 2014-05-27 2018-02-20 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
WO2015193859A1 (en) 2014-06-19 2015-12-23 Sabic Global Technologies B.V. Brominated cross-linkable polycarbonate compositions
US9603937B2 (en) * 2015-03-09 2017-03-28 Theaprin Pharmaceuticals Inc. Platform drug delivery system utilizing crystal engineering and theanine dissolution
US10376464B2 (en) * 2015-11-25 2019-08-13 Theaprin Pharmaceuticals Inc. Characterization of the cocrystal products formed by metoprolol and dabigatran bases with L-theanine
CN114656446A (zh) 2015-11-25 2022-06-24 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体配合物
JP2019520377A (ja) 2016-06-28 2019-07-18 アサメディック アクティーゼルスカブＡｓａｍｅｄｉｃ Ａｓ 二成分組成物
CA3101168A1 (en) * 2017-05-30 2018-12-06 Theaprin Pharmaceuticals, Inc. Sublingual formulation with water-soluble cocrystals of acetylsalicylic acid with citric acid, sodium bicarbonate, and l-theanine for the treatment of acute myocardial infarction
WO2019049049A1 (en) 2017-09-05 2019-03-14 R. J. Reynolds Tobacco Company SALTS, CO-CRYSTALS, AND CO-CRYSTAL COMPLEXES OF NICOTINE SALTS
EP3501522A1 (en) 2017-12-22 2019-06-26 Asamedic AS Compositions comprising acetylsalicylic acid and a phosphate salt
EP3501523A1 (en) 2017-12-22 2019-06-26 Asamedic AS Two-component compositions comprising acetyl salicylic acid and a carbonate salt
CA3178188A1 (en) * 2020-05-08 2021-11-11 Philip V. Felice Cocrystal antioxidants of protocatechuic acid with l-theanine for the treatment of oxidative stress and inflammatory conditions
CN111870558B (zh) * 2020-08-17 2022-07-12 山东华熙海御生物医药有限公司 一种抑制透明质酸酶活性的组合物及皮肤护理产品
CA3216616A1 (en) * 2021-04-27 2022-11-03 Philip V. Felice Compositions comprising cocrystals of acetylsalicylic acid and theanine with tromethamine and methods of use

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WO2002096870A2 (en) 2001-05-31 2002-12-05 The Regents Of The University Of California Sponge-derived terpenoids and methods of use
DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539350C1 (ru) * 2013-12-24 2015-01-20 Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской академии наук (ИХР РАН) Сокристаллическая форма 2-гидроксибензамида с салициловой кислотой

Also Published As

Publication number Publication date
US20130012482A1 (en) 2013-01-10
AU2009345832A1 (en) 2011-11-17
US20140288029A1 (en) 2014-09-25
US20140296189A1 (en) 2014-10-02
US8476250B2 (en) 2013-07-02
EP2427196A1 (en) 2012-03-14
US20140235594A1 (en) 2014-08-21
US20130345183A1 (en) 2013-12-26
MX2011011871A (es) 2012-03-06
WO2010128977A1 (en) 2010-11-11
IL215922A0 (en) 2011-12-29
KR101603368B1 (ko) 2016-03-14
NZ596200A (en) 2013-04-26
EP2427196B1 (en) 2015-11-04
US8173625B2 (en) 2012-05-08
KR20120011031A (ko) 2012-02-06
US9289440B2 (en) 2016-03-22
US8304404B2 (en) 2012-11-06
HK1164162A1 (en) 2012-09-21
CA2760555C (en) 2014-08-19
CN102421438B (zh) 2014-04-02
SG175921A1 (en) 2011-12-29
US9289439B2 (en) 2016-03-22
CA2760555A1 (en) 2010-11-11
US20100286099A1 (en) 2010-11-11
EA022058B1 (ru) 2015-10-30
JP5568127B2 (ja) 2014-08-06
IL215922A (en) 2014-06-30
CN102421438A (zh) 2012-04-18
US20140343021A1 (en) 2014-11-20
US20140148418A1 (en) 2014-05-29
JP2012526105A (ja) 2012-10-25
US20120190655A1 (en) 2012-07-26
US20130123218A1 (en) 2013-05-16
US8685948B2 (en) 2014-04-01
EP2427196A4 (en) 2012-10-17
US20140179644A1 (en) 2014-06-26
US9289438B2 (en) 2016-03-22

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