EA201100488A1 - Лиганды, которые обладают специфичностью связывания в отношении dc-sign - Google Patents

Лиганды, которые обладают специфичностью связывания в отношении dc-sign

Info

Publication number
EA201100488A1
EA201100488A1 EA201100488A EA201100488A EA201100488A1 EA 201100488 A1 EA201100488 A1 EA 201100488A1 EA 201100488 A EA201100488 A EA 201100488A EA 201100488 A EA201100488 A EA 201100488A EA 201100488 A1 EA201100488 A1 EA 201100488A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sign
ligands
specific binding
compositions
binding relation
Prior art date
Application number
EA201100488A
Other languages
English (en)
Inventor
Рудольф Мария Де Вильдт
Original Assignee
Домантис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Домантис Лимитед filed Critical Домантис Лимитед
Publication of EA201100488A1 publication Critical patent/EA201100488A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

В настоящем изобретении предложен единичный вариабельный домен иммуноглобулина против специфического для дендритных клеток ICAM-3-захватывающего неинтегрина (DC-SIGN; CD209). Также описаны полипептиды, лиганды и композиции, содержащие такие единичные вариабельные домены иммуноглобулина против DC-SIGN, вместе с нуклеиновыми кислотами, кодирующими такие иммуноглобулины, а также векторами и клетками-хозяевами для экспрессии. Кроме того, изобретение относится к применениям, препаратам, композициям и устройствам, содержащим такие DC-SIGN-связывающие агенты.
EA201100488A 2008-10-21 2009-10-19 Лиганды, которые обладают специфичностью связывания в отношении dc-sign EA201100488A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10708508P 2008-10-21 2008-10-21
PCT/EP2009/063655 WO2010046337A2 (en) 2008-10-21 2009-10-19 Ligands that have binding specificity for dc-sign

Publications (1)

Publication Number Publication Date
EA201100488A1 true EA201100488A1 (ru) 2011-12-30

Family

ID=42062429

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100488A EA201100488A1 (ru) 2008-10-21 2009-10-19 Лиганды, которые обладают специфичностью связывания в отношении dc-sign

Country Status (16)

Country Link
US (1) US20110257373A1 (ru)
EP (1) EP2356149A2 (ru)
JP (1) JP2012506237A (ru)
KR (1) KR20110071139A (ru)
CN (1) CN102257009A (ru)
AR (1) AR073905A1 (ru)
AU (1) AU2009306424A1 (ru)
BR (1) BRPI0919714A2 (ru)
CA (1) CA2740856A1 (ru)
EA (1) EA201100488A1 (ru)
IL (1) IL212086A0 (ru)
MX (1) MX2011004244A (ru)
TW (1) TW201019962A (ru)
UY (1) UY32189A (ru)
WO (1) WO2010046337A2 (ru)
ZA (1) ZA201102763B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201100485A1 (ru) * 2008-10-21 2011-12-30 Домантис Лимитед Композиции для нацеливания на дендритные клетки
US9481724B2 (en) * 2011-12-19 2016-11-01 The Rockefeller University hDC-sign binding peptides
EP4392022A2 (en) * 2021-08-27 2024-07-03 University of Georgia Research Foundation, Inc. Targeted nanoparticles and their uses related to infectious disease
CN118184795A (zh) * 2022-12-13 2024-06-14 成都维瑾柏鳌生物医药科技有限公司 抗hiv-1的重组蛋白及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07502417A (ja) * 1992-06-05 1995-03-16 バクスター、ダイアグノスチックス、インコーポレイテッド 家兎単一ドメイン抗体及びその使用
CA2505326A1 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders
MXPA05006043A (es) * 2003-01-10 2006-01-30 Ablynx Nv Polipeptidos terapeuticos, homologos de los mismos, fragmentos de los mismos y para uso al modular la agregacion mediada de plaquetas.
EP1627062A1 (en) * 2003-05-14 2006-02-22 Domantis Limited A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
ES2315664T3 (es) * 2003-06-30 2009-04-01 Domantis Limited Anticuerpos de dominio unico (dab) pegilados.
US20070026057A1 (en) * 2003-08-21 2007-02-01 Lipotek Pty Ltd. In vivo targeting of dendritic cells
EP1784427A2 (en) * 2004-06-01 2007-05-16 Domantis Limited Bispecific fusion antibodies with enhanced serum half-life
CN101133084A (zh) * 2004-12-02 2008-02-27 多曼蒂斯有限公司 采用白细胞介素-1ⅰ型受体拮抗剂治疗呼吸道疾病的方法
CN101128487B (zh) * 2004-12-02 2012-10-10 杜门蒂斯有限公司 靶向血清白蛋白和glp-1或pyy的双特异性结构域抗体
MX2007011356A (es) * 2005-03-18 2008-03-10 Domantis Ltd Anticuerpos contra antigenos de candida.
EP1963370A1 (en) * 2005-12-06 2008-09-03 Domantis Limited Bispecific ligands with binding specificity to cell surface targets and methods of use therefor
EA013878B1 (ru) * 2005-12-06 2010-08-30 Домантис Лимитед Лиганды, имеющие специфичность связывания в отношении рецептора эпидермального фактора роста (egfr) и/или сосудистого эндотелиального фактора роста (vegf), и способы их применения
WO2007085815A2 (en) * 2006-01-24 2007-08-02 Domantis Limited Ligands that bind il-4 and/or il-13
US20080152648A1 (en) * 2006-09-26 2008-06-26 Alexion Pharmaceuticals, Inc. Compositions and methods for enhancing an adjuvant
US20100143371A1 (en) * 2006-10-31 2010-06-10 Zhenping Zhu Intrabodies
CN101182539A (zh) * 2007-11-06 2008-05-21 浙江大学 Dc-sign启动子荧光素酶报告质粒的构建方法

Also Published As

Publication number Publication date
TW201019962A (en) 2010-06-01
MX2011004244A (es) 2011-05-25
CN102257009A (zh) 2011-11-23
CA2740856A1 (en) 2010-04-29
EP2356149A2 (en) 2011-08-17
US20110257373A1 (en) 2011-10-20
UY32189A (es) 2010-05-31
IL212086A0 (en) 2011-06-30
ZA201102763B (en) 2012-09-26
KR20110071139A (ko) 2011-06-28
WO2010046337A2 (en) 2010-04-29
BRPI0919714A2 (pt) 2015-12-08
AR073905A1 (es) 2010-12-09
JP2012506237A (ja) 2012-03-15
AU2009306424A1 (en) 2010-04-29
WO2010046337A3 (en) 2010-07-01

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