EA201070129A1 - Фармацевтический сухой порошкообразный аэрозольный состав, включающий полипептид, и способ его приготовления - Google Patents
Фармацевтический сухой порошкообразный аэрозольный состав, включающий полипептид, и способ его приготовленияInfo
- Publication number
- EA201070129A1 EA201070129A1 EA201070129A EA201070129A EA201070129A1 EA 201070129 A1 EA201070129 A1 EA 201070129A1 EA 201070129 A EA201070129 A EA 201070129A EA 201070129 A EA201070129 A EA 201070129A EA 201070129 A1 EA201070129 A1 EA 201070129A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- preparation
- aerosol composition
- including polypeptide
- pharmaceutical dry
- shaped aerosol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Abstract
Описаны диспергируемые порошковые композиции, пригодные для ингаляции (вдыхания), причем указанные композиции включают мутеин интерлейкина человека (mhIL-4).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95926707P | 2007-07-11 | 2007-07-11 | |
PCT/US2008/069889 WO2009009775A1 (en) | 2007-07-11 | 2008-07-11 | Pharmaceutical polypeptide dry powder aerosol formulation and method of preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201070129A1 true EA201070129A1 (ru) | 2010-10-29 |
Family
ID=40229103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070129A EA201070129A1 (ru) | 2007-07-11 | 2008-07-11 | Фармацевтический сухой порошкообразный аэрозольный состав, включающий полипептид, и способ его приготовления |
Country Status (9)
Country | Link |
---|---|
US (4) | US20110005523A1 (ru) |
EP (1) | EP2178547A4 (ru) |
JP (1) | JP2010533204A (ru) |
KR (1) | KR20100047866A (ru) |
CN (1) | CN101784280A (ru) |
AU (1) | AU2008274938A1 (ru) |
CA (1) | CA2693785A1 (ru) |
EA (1) | EA201070129A1 (ru) |
WO (1) | WO2009009775A1 (ru) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009079078A1 (en) | 2007-12-14 | 2009-06-25 | Labogroup S.A.S. | Delivering aerosolizable food products |
EP2580236B1 (en) | 2010-06-08 | 2019-04-03 | Pieris Pharmaceuticals GmbH | Tear lipocalin muteins binding il-4 r alpha |
TWI666447B (zh) | 2010-12-16 | 2019-07-21 | 建南德克公司 | 關於th2抑制作用之診斷及治療 |
CN102553040B (zh) * | 2010-12-17 | 2014-07-02 | 陈庆堂 | 滤出药粉吸入器 |
CN103998053B9 (zh) | 2011-12-13 | 2020-07-21 | 皮里斯制药有限公司 | 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 |
US9481777B2 (en) | 2012-03-30 | 2016-11-01 | The Procter & Gamble Company | Method of dewatering in a continuous high internal phase emulsion foam forming process |
WO2015061441A1 (en) | 2013-10-23 | 2015-04-30 | Genentech, Inc. | Methods of diagnosing and treating eosinophilic disorders |
SG11201606870XA (en) | 2014-02-21 | 2016-09-29 | Genentech Inc | Anti-il-13/il-17 bispecific antibodies and uses thereof |
NO2709641T3 (ru) * | 2014-03-10 | 2018-05-12 | ||
MX2017011486A (es) | 2015-03-16 | 2018-06-15 | Genentech Inc | Métodos de detección y cuantificación de il-13 y sus usos en el diagnóstico y tratamiento de enfermedades asociadas a th2. |
PL3481471T3 (pl) * | 2016-07-07 | 2021-01-11 | Philip Morris Products S.A. | Układ inhalatora nikotyny |
CA3226165A1 (en) | 2018-02-09 | 2019-08-15 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
EP3553078A1 (en) | 2018-04-11 | 2019-10-16 | Julius-Maximilians-Universität Würzburg | Glyco-engineered interleukin-4 based antagonists |
WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
WO2024043900A1 (en) * | 2022-08-26 | 2024-02-29 | Cummins Filtration Inc. | Filtration system with additive |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679338A (en) * | 1994-05-12 | 1997-10-21 | Osteoarthritis Science, Inc. | Use of IL-4 for inhibition of the breakdown of articular cartilage and other tissues |
DE4423131A1 (de) * | 1994-07-01 | 1996-01-04 | Bayer Ag | Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4 |
US6028176A (en) * | 1996-07-19 | 2000-02-22 | Bayer Corporation | High-affinity interleukin-4 muteins |
CA2432175C (en) * | 2000-12-21 | 2010-08-10 | Jayne E. Hastedt | Storage stable powder compositions of interleukin-4 receptor |
ITMI20010357U1 (it) * | 2001-06-28 | 2002-12-30 | Plastiape Spa | Dispositivo inalatore |
WO2003030974A1 (en) * | 2001-10-08 | 2003-04-17 | Eli Lilly And Company | Portable medication inhalation kit |
US20050031549A1 (en) * | 2003-06-09 | 2005-02-10 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of growth hormone |
US7404957B2 (en) * | 2003-08-29 | 2008-07-29 | Aerovance, Inc. | Modified IL-4 mutein receptor antagonists |
EP1713441A2 (en) * | 2004-02-12 | 2006-10-25 | Nektar Therapeutics | Interleukin-13 antagonist powders, spray-dried particles, and methods |
US7635754B2 (en) * | 2004-09-22 | 2009-12-22 | Aerovance, Inc. | Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same |
AU2007204879A1 (en) * | 2006-01-11 | 2007-07-19 | Aerovance, Inc. | Methods and compositions for treating asthma in human and non human primates |
-
2008
- 2008-07-11 WO PCT/US2008/069889 patent/WO2009009775A1/en active Application Filing
- 2008-07-11 CN CN200880103277A patent/CN101784280A/zh active Pending
- 2008-07-11 AU AU2008274938A patent/AU2008274938A1/en not_active Abandoned
- 2008-07-11 JP JP2010516289A patent/JP2010533204A/ja active Pending
- 2008-07-11 EP EP08781742A patent/EP2178547A4/en not_active Withdrawn
- 2008-07-11 EA EA201070129A patent/EA201070129A1/ru unknown
- 2008-07-11 KR KR1020107003128A patent/KR20100047866A/ko not_active Application Discontinuation
- 2008-07-11 CA CA2693785A patent/CA2693785A1/en not_active Abandoned
-
2009
- 2009-09-30 US US12/571,359 patent/US20110005523A1/en not_active Abandoned
- 2009-09-30 US US12/571,347 patent/US20110262384A1/en not_active Abandoned
-
2010
- 2010-10-26 US US12/912,159 patent/US20110287256A1/en not_active Abandoned
- 2010-10-26 US US12/912,398 patent/US20110284412A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20100047866A (ko) | 2010-05-10 |
US20110262384A1 (en) | 2011-10-27 |
JP2010533204A (ja) | 2010-10-21 |
US20110284412A1 (en) | 2011-11-24 |
EP2178547A1 (en) | 2010-04-28 |
AU2008274938A1 (en) | 2009-01-15 |
CN101784280A (zh) | 2010-07-21 |
WO2009009775A1 (en) | 2009-01-15 |
EP2178547A4 (en) | 2011-02-16 |
US20110005523A1 (en) | 2011-01-13 |
CA2693785A1 (en) | 2009-01-15 |
US20110287256A1 (en) | 2011-11-24 |
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