EA201000889A1 - Тризамещенные пиперидины в качестве ингибиторов ренина - Google Patents
Тризамещенные пиперидины в качестве ингибиторов ренинаInfo
- Publication number
- EA201000889A1 EA201000889A1 EA201000889A EA201000889A EA201000889A1 EA 201000889 A1 EA201000889 A1 EA 201000889A1 EA 201000889 A EA201000889 A EA 201000889A EA 201000889 A EA201000889 A EA 201000889A EA 201000889 A1 EA201000889 A1 EA 201000889A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- piperidines
- renin inhibitors
- triple
- spreading
- salts
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 239000002461 renin inhibitor Substances 0.000 title abstract 2
- 229940086526 renin-inhibitors Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
В заявке описаны тризамещенные пиперидины общей формулыи их соли, предпочтительно их фармацевтически приемлемые соли, в которой R, R, X, U, W, m и n обладают значениями, указанными в описании, способ их получения и применение этих соединений в качестве лекарственных средств, в особенности в качестве ингибиторов ренина.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07150019 | 2007-12-13 | ||
PCT/EP2008/067407 WO2009074674A2 (en) | 2007-12-13 | 2008-12-12 | Trisubstituted piperidines as renin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201000889A1 true EA201000889A1 (ru) | 2011-02-28 |
Family
ID=39709362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000889A EA201000889A1 (ru) | 2007-12-13 | 2008-12-12 | Тризамещенные пиперидины в качестве ингибиторов ренина |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110009399A1 (ru) |
EP (1) | EP2231677A2 (ru) |
JP (1) | JP2011506401A (ru) |
KR (1) | KR20100097731A (ru) |
CN (1) | CN101896490A (ru) |
AR (1) | AR069677A1 (ru) |
AU (1) | AU2008334555A1 (ru) |
BR (1) | BRPI0819920A2 (ru) |
CA (1) | CA2708570A1 (ru) |
EA (1) | EA201000889A1 (ru) |
TW (1) | TW200940547A (ru) |
WO (1) | WO2009074674A2 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2708866A1 (en) | 2007-12-19 | 2009-06-25 | Hiroyuki Nakahira | Bicyclic heterocyclic derivative |
EP2447264A4 (en) | 2009-06-24 | 2012-12-12 | Dainippon Sumitomo Pharma Co | N-SUBSTITUTED CYCLIC AMINO DERIVATIVE |
EP2488530A4 (en) * | 2009-10-13 | 2014-03-19 | Merck Canada Inc | INHIBITORS OF THE RENIN |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200900399A (en) * | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
PL1904477T3 (pl) * | 2005-07-14 | 2009-07-31 | Hoffmann La Roche | Pochodne indolo-3-karbonylo-spiro-piperydyny jako antagoniści receptora V1a |
-
2008
- 2008-12-11 TW TW097148138A patent/TW200940547A/zh unknown
- 2008-12-12 JP JP2010537459A patent/JP2011506401A/ja active Pending
- 2008-12-12 WO PCT/EP2008/067407 patent/WO2009074674A2/en active Application Filing
- 2008-12-12 KR KR1020107015329A patent/KR20100097731A/ko not_active Application Discontinuation
- 2008-12-12 CN CN2008801207312A patent/CN101896490A/zh active Pending
- 2008-12-12 EP EP08859256A patent/EP2231677A2/en not_active Withdrawn
- 2008-12-12 BR BRPI0819920-5A patent/BRPI0819920A2/pt not_active IP Right Cessation
- 2008-12-12 AR ARP080105411A patent/AR069677A1/es unknown
- 2008-12-12 AU AU2008334555A patent/AU2008334555A1/en not_active Abandoned
- 2008-12-12 CA CA2708570A patent/CA2708570A1/en not_active Abandoned
- 2008-12-12 US US12/745,960 patent/US20110009399A1/en not_active Abandoned
- 2008-12-12 EA EA201000889A patent/EA201000889A1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009074674A3 (en) | 2009-07-30 |
KR20100097731A (ko) | 2010-09-03 |
CN101896490A (zh) | 2010-11-24 |
US20110009399A1 (en) | 2011-01-13 |
WO2009074674A2 (en) | 2009-06-18 |
AU2008334555A1 (en) | 2009-06-18 |
CA2708570A1 (en) | 2009-06-18 |
EP2231677A2 (en) | 2010-09-29 |
JP2011506401A (ja) | 2011-03-03 |
BRPI0819920A2 (pt) | 2015-05-19 |
AR069677A1 (es) | 2010-02-10 |
TW200940547A (en) | 2009-10-01 |
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