EA201000501A1 - PHARMACEUTICAL COMPOSITION CONTAINING NO NEUROQUATIC PRESENTING PLASMINOGEN ACTIVATOR FOR TREATMENT - Google Patents

PHARMACEUTICAL COMPOSITION CONTAINING NO NEUROQUATIC PRESENTING PLASMINOGEN ACTIVATOR FOR TREATMENT

Info

Publication number
EA201000501A1
EA201000501A1 EA201000501A EA201000501A EA201000501A1 EA 201000501 A1 EA201000501 A1 EA 201000501A1 EA 201000501 A EA201000501 A EA 201000501A EA 201000501 A EA201000501 A EA 201000501A EA 201000501 A1 EA201000501 A1 EA 201000501A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
plasminogen activator
neuroquatic
presenting
treatment
Prior art date
Application number
EA201000501A
Other languages
Russian (ru)
Inventor
Мариола Зенген
Вольфганг Зенген
Вольф-Дитер Шлойнинг
Роберт Медкаф
Original Assignee
Пайон Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пайон Дойчланд Гмбх filed Critical Пайон Дойчланд Гмбх
Publication of EA201000501A1 publication Critical patent/EA201000501A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к фармацевтической композиции, содержащей активатор плазминогена из слюны Desmodus rotundus (DSPA) альфа 1, для терапевтического лечения удара у людей. Фармацевтическая композиция содержит от 60 до 230 мкг/кг DSPA альфа 1 и предназначена для применения в виде капельной инфузии и болюсной инъекции.The invention relates to a pharmaceutical composition comprising salivary plasminogen activator Desmodus rotundus (DSPA) alpha 1 for the therapeutic treatment of stroke in humans. The pharmaceutical composition contains from 60 to 230 μg / kg DSPA alpha 1 and is intended for use in the form of a drip infusion and a bolus injection.

EA201000501A 2003-05-02 2004-04-30 PHARMACEUTICAL COMPOSITION CONTAINING NO NEUROQUATIC PRESENTING PLASMINOGEN ACTIVATOR FOR TREATMENT EA201000501A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP03/04608 2003-05-02
PCT/EP2003/004729 WO2004096267A1 (en) 2003-05-02 2003-05-06 Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke

Publications (1)

Publication Number Publication Date
EA201000501A1 true EA201000501A1 (en) 2010-10-29

Family

ID=33395696

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201000501A EA201000501A1 (en) 2003-05-02 2004-04-30 PHARMACEUTICAL COMPOSITION CONTAINING NO NEUROQUATIC PRESENTING PLASMINOGEN ACTIVATOR FOR TREATMENT
EA200501733A EA013837B1 (en) 2003-05-02 2004-04-30 A METHOD FOR TREATING A HUMAN CEREBRAL STROKE COMPRISING ADMINISTERING PLASMINOGEN ACTIVATORS α1 FROM DESMODUS ROTUNDUS

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200501733A EA013837B1 (en) 2003-05-02 2004-04-30 A METHOD FOR TREATING A HUMAN CEREBRAL STROKE COMPRISING ADMINISTERING PLASMINOGEN ACTIVATORS α1 FROM DESMODUS ROTUNDUS

Country Status (14)

Country Link
JP (1) JP2012077090A (en)
CN (1) CN1849133B (en)
AU (3) AU2003227721A1 (en)
CY (1) CY1114254T1 (en)
DK (1) DK1622639T3 (en)
EA (2) EA201000501A1 (en)
ES (1) ES2401782T3 (en)
HK (1) HK1092045A1 (en)
IL (1) IL171636A (en)
MY (1) MY151447A (en)
PT (1) PT1622639E (en)
SI (1) SI1622639T1 (en)
WO (1) WO2004096267A1 (en)
ZA (2) ZA200703704B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10153601A1 (en) 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke
TWI445540B (en) 2007-04-20 2014-07-21 Ajinomoto Kk Anti-hypothermia composition
AR067345A1 (en) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
NL8902454A (en) * 1989-10-03 1991-05-01 Stichting Centraal Lab MUTANTS OF THE HUMANE PLASMINOGENIC ACTIVATOR INHIBITOR 1 (PAI-1), THEIR PREPARATION AND USE, AND RECOMBINANT POLYNUCLEOTIDES INCLUDING GENETIC INFORMATION CODING FOR THESE MUTANTS.
EP0530937B1 (en) * 1991-09-05 1998-08-12 Schering Aktiengesellschaft Collagen-induced platelet aggregation inhibitor
DE10153601A1 (en) * 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke

Also Published As

Publication number Publication date
JP2012077090A (en) 2012-04-19
EA013837B1 (en) 2010-08-30
HK1092045A1 (en) 2007-02-02
SI1622639T1 (en) 2013-05-31
CN1849133A (en) 2006-10-18
AU2003227721A1 (en) 2004-11-23
MY151447A (en) 2014-05-30
PT1622639E (en) 2013-04-01
ZA200703704B (en) 2008-08-27
CN1849133B (en) 2011-03-30
AU2010200718A1 (en) 2010-03-18
ZA200509053B (en) 2007-11-28
ES2401782T3 (en) 2013-04-24
AU2004233601B2 (en) 2009-11-26
WO2004096267A1 (en) 2004-11-11
EA200501733A1 (en) 2006-06-30
IL171636A (en) 2013-07-31
AU2004233601A1 (en) 2004-11-11
CY1114254T1 (en) 2016-08-31
DK1622639T3 (en) 2013-04-15

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