AR067345A1 - USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT - Google Patents

USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT

Info

Publication number
AR067345A1
AR067345A1 ARP080102791A ARP080102791A AR067345A1 AR 067345 A1 AR067345 A1 AR 067345A1 AR P080102791 A ARP080102791 A AR P080102791A AR P080102791 A ARP080102791 A AR P080102791A AR 067345 A1 AR067345 A1 AR 067345A1
Authority
AR
Argentina
Prior art keywords
thrombomodulin
preparation
thrombolitic
medicinal product
patient
Prior art date
Application number
ARP080102791A
Other languages
Spanish (es)
Inventor
Benning Brohmann
Daniel A Lawrence
Karl-Uwe Petersen
Original Assignee
Paion Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40229136&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067345(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP07013480A external-priority patent/EP2014296A1/en
Application filed by Paion Deutschland Gmbh filed Critical Paion Deutschland Gmbh
Publication of AR067345A1 publication Critical patent/AR067345A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Uso de trombomodulina para la preparacion de un medicamento para estimular la reperfusion de un tejido u organo isquémico en un paciente que la necesita, en particular un paciente apopléjico. Reivindicacion 15: Uso segun cualquiera de las reivindicaciones precedentes, en el cual la trombomodulina tiene una secuencia de aminoácido correspondiente a la secuencia de aminoácido de trombomodulina soluble madura y comprende una o más de las siguientes modificaciones: Eliminacion de aminoácidos 1-3, M388L, R456, H457Q, S474A, y terminando en P490.Use of thrombomodulin for the preparation of a medicament to stimulate the reperfusion of an ischemic tissue or organ in a patient in need, in particular an apoplegic patient. Claim 15: Use according to any of the preceding claims, wherein the thrombomodulin has an amino acid sequence corresponding to the mature soluble thrombomodulin amino acid sequence and comprises one or more of the following modifications: Elimination of amino acids 1-3, M388L, R456, H457Q, S474A, and ending at P490.

ARP080102791A 2007-07-10 2008-06-27 USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT AR067345A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07013480A EP2014296A1 (en) 2007-07-10 2007-07-10 Novel strategies for increasing the reperfusion in obstructed blood vessel
EP08009096 2008-05-16
EP08010333 2008-06-06

Publications (1)

Publication Number Publication Date
AR067345A1 true AR067345A1 (en) 2009-10-07

Family

ID=40229136

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102791A AR067345A1 (en) 2007-07-10 2008-06-27 USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT

Country Status (5)

Country Link
EP (1) EP2175872A2 (en)
JP (1) JP2010532776A (en)
AR (1) AR067345A1 (en)
CL (1) CL2008001977A1 (en)
WO (1) WO2009007112A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2580756C2 (en) 2011-11-15 2016-04-10 Асахи Касеи Фарма Корпорейшн Medicament for therapeutic treatment and/or improvement of sepsis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0641215B1 (en) * 1992-02-05 2004-04-21 Paion GmbH Protease-resistant thrombomodulin analogs
DK0946185T4 (en) * 1996-11-27 2010-08-30 Aventis Pharma Inc A pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
US20010041686A1 (en) * 2000-01-06 2001-11-15 Veronique Mary Novel therapeutic application of enoxaparin
US20020111296A1 (en) * 2000-08-31 2002-08-15 Festoff Barry W. Thrombomodulin analogs for use in recovery of spinal cord injury
DE60206037T2 (en) * 2001-05-25 2006-07-13 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. LECTIN-RELATED DOMAIN OF THROMBOMODULIN AND THERAPEUTIC USE THEREOF
ATE550073T1 (en) * 2001-06-13 2012-04-15 Univ Sydney PROTEIN C FOR WOUND HEALING
AU2003227721A1 (en) * 2003-05-02 2004-11-23 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke

Also Published As

Publication number Publication date
WO2009007112A3 (en) 2009-04-16
WO2009007112A4 (en) 2009-06-11
WO2009007112A2 (en) 2009-01-15
JP2010532776A (en) 2010-10-14
CL2008001977A1 (en) 2009-03-06
EP2175872A2 (en) 2010-04-21

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