AR067345A1 - USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT - Google Patents
USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCTInfo
- Publication number
- AR067345A1 AR067345A1 ARP080102791A ARP080102791A AR067345A1 AR 067345 A1 AR067345 A1 AR 067345A1 AR P080102791 A ARP080102791 A AR P080102791A AR P080102791 A ARP080102791 A AR P080102791A AR 067345 A1 AR067345 A1 AR 067345A1
- Authority
- AR
- Argentina
- Prior art keywords
- thrombomodulin
- preparation
- thrombolitic
- medicinal product
- patient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/366—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Uso de trombomodulina para la preparacion de un medicamento para estimular la reperfusion de un tejido u organo isquémico en un paciente que la necesita, en particular un paciente apopléjico. Reivindicacion 15: Uso segun cualquiera de las reivindicaciones precedentes, en el cual la trombomodulina tiene una secuencia de aminoácido correspondiente a la secuencia de aminoácido de trombomodulina soluble madura y comprende una o más de las siguientes modificaciones: Eliminacion de aminoácidos 1-3, M388L, R456, H457Q, S474A, y terminando en P490.Use of thrombomodulin for the preparation of a medicament to stimulate the reperfusion of an ischemic tissue or organ in a patient in need, in particular an apoplegic patient. Claim 15: Use according to any of the preceding claims, wherein the thrombomodulin has an amino acid sequence corresponding to the mature soluble thrombomodulin amino acid sequence and comprises one or more of the following modifications: Elimination of amino acids 1-3, M388L, R456, H457Q, S474A, and ending at P490.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07013480A EP2014296A1 (en) | 2007-07-10 | 2007-07-10 | Novel strategies for increasing the reperfusion in obstructed blood vessel |
EP08009096 | 2008-05-16 | ||
EP08010333 | 2008-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067345A1 true AR067345A1 (en) | 2009-10-07 |
Family
ID=40229136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102791A AR067345A1 (en) | 2007-07-10 | 2008-06-27 | USE OF THROMBOMODULIN FOR THE PREPARATION OF A THROMBOLITIC MEDICINAL PRODUCT |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2175872A2 (en) |
JP (1) | JP2010532776A (en) |
AR (1) | AR067345A1 (en) |
CL (1) | CL2008001977A1 (en) |
WO (1) | WO2009007112A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2580756C2 (en) | 2011-11-15 | 2016-04-10 | Асахи Касеи Фарма Корпорейшн | Medicament for therapeutic treatment and/or improvement of sepsis |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0641215B1 (en) * | 1992-02-05 | 2004-04-21 | Paion GmbH | Protease-resistant thrombomodulin analogs |
DK0946185T4 (en) * | 1996-11-27 | 2010-08-30 | Aventis Pharma Inc | A pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound |
US20010041686A1 (en) * | 2000-01-06 | 2001-11-15 | Veronique Mary | Novel therapeutic application of enoxaparin |
US20020111296A1 (en) * | 2000-08-31 | 2002-08-15 | Festoff Barry W. | Thrombomodulin analogs for use in recovery of spinal cord injury |
DE60206037T2 (en) * | 2001-05-25 | 2006-07-13 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | LECTIN-RELATED DOMAIN OF THROMBOMODULIN AND THERAPEUTIC USE THEREOF |
ATE550073T1 (en) * | 2001-06-13 | 2012-04-15 | Univ Sydney | PROTEIN C FOR WOUND HEALING |
AU2003227721A1 (en) * | 2003-05-02 | 2004-11-23 | Paion Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
-
2008
- 2008-06-27 AR ARP080102791A patent/AR067345A1/en unknown
- 2008-07-04 CL CL2008001977A patent/CL2008001977A1/en unknown
- 2008-07-10 WO PCT/EP2008/005623 patent/WO2009007112A2/en active Application Filing
- 2008-07-10 JP JP2010515412A patent/JP2010532776A/en not_active Withdrawn
- 2008-07-10 EP EP08784685A patent/EP2175872A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2009007112A3 (en) | 2009-04-16 |
WO2009007112A4 (en) | 2009-06-11 |
WO2009007112A2 (en) | 2009-01-15 |
JP2010532776A (en) | 2010-10-14 |
CL2008001977A1 (en) | 2009-03-06 |
EP2175872A2 (en) | 2010-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |