EA200900088A1 - Лекарственный препарат для улучшения когнитивной функции и нейропротекции - Google Patents

Лекарственный препарат для улучшения когнитивной функции и нейропротекции

Info

Publication number
EA200900088A1
EA200900088A1 EA200900088A EA200900088A EA200900088A1 EA 200900088 A1 EA200900088 A1 EA 200900088A1 EA 200900088 A EA200900088 A EA 200900088A EA 200900088 A EA200900088 A EA 200900088A EA 200900088 A1 EA200900088 A1 EA 200900088A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cognitive function
improving cognitive
pyridazinone
isoxazol
benz
Prior art date
Application number
EA200900088A
Other languages
English (en)
Other versions
EA016142B1 (ru
Inventor
Иштван Гачайи
Габор Гиглер
Марта Агоштон
Хайналка Компагне
Сабольч Кертес
Кристина Мориц
Дьёрдь Леваи
Габор Сенаши
Ласло Габор Харшинг
Йожеф Баркоци
Дьюла Шимиг
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Publication of EA200900088A1 publication Critical patent/EA200900088A1/ru
Publication of EA016142B1 publication Critical patent/EA016142B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к применению 4-хлор-5-{2-[4-(6-фтор-1,2-бенз[d]изоксазол-3-ил)пиперидин-1-ил]этиламино}-2-метил-3-(2Н)пиридазинона формулы (I)или его фармацевтически приемлемых солей для получения лекарственных препаратов, пригодных для улучшения когнитивной функции или получения нейропротективного эффекта. Лекарственные препараты, содержащие 4-хлор-5-{2-[4-(6-фтор-1,2-бенз[d]изоксазол-3-ил)пиперидин-1-ил]этиламино}-2-метил-3-(2Н)пиридазинон формулы (I) или его терапевтически приемлемую соль, можно применять для лечения или предотвращения гибели нейронов, слабоумия, рассеянного склероза, болезни Крейцфельда-Якоба, синдрома Хантингтона, бокового амиотрофического склероза, болезни Паркинсона, нарушения памяти, потери памяти, амнезии, инсульта или для улучшения функций памяти или способности к обучению.
EA200900088A 2006-07-03 2007-07-03 ПРИМЕНЕНИЕ 4-ХЛОР-5-{2-[4-(6-ФТОР-1,2-БЕНЗ[d]ИЗОКСАЗОЛ-3-ИЛ)ПИПЕРИДИН-1-ИЛ]ЭТИЛАМИНО}-2-МЕТИЛ-3-(2H) ПИРИДАЗИНОНА ИЛИ ЕГО ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ ДЛЯ НЕЙРОПРОТЕКЦИИ (ВАРИАНТЫ), ЛЕКАРСТВЕННЫЙ ПРЕПАРАТ (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ (ВАРИАНТЫ) EA016142B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0600555A HUP0600555A3 (en) 2006-07-03 2006-07-03 Use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]izoxazol-3-yl)piperidin-1-yl]ethylamino}2-methyl-3(2h)-piridazinon for the production of pharmaceutical compositions for influencing cognitive functions and causing neuroprotective effect
PCT/HU2007/000059 WO2008004013A2 (en) 2006-07-03 2007-07-03 Medicament for the enhancement of cognitive function and neuroprotection

Publications (2)

Publication Number Publication Date
EA200900088A1 true EA200900088A1 (ru) 2009-12-30
EA016142B1 EA016142B1 (ru) 2012-02-28

Family

ID=89986887

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900088A EA016142B1 (ru) 2006-07-03 2007-07-03 ПРИМЕНЕНИЕ 4-ХЛОР-5-{2-[4-(6-ФТОР-1,2-БЕНЗ[d]ИЗОКСАЗОЛ-3-ИЛ)ПИПЕРИДИН-1-ИЛ]ЭТИЛАМИНО}-2-МЕТИЛ-3-(2H) ПИРИДАЗИНОНА ИЛИ ЕГО ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ ДЛЯ НЕЙРОПРОТЕКЦИИ (ВАРИАНТЫ), ЛЕКАРСТВЕННЫЙ ПРЕПАРАТ (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ (ВАРИАНТЫ)

Country Status (26)

Country Link
US (1) US8318743B2 (ru)
EP (1) EP2049113B8 (ru)
JP (1) JP5174018B2 (ru)
KR (1) KR101465415B1 (ru)
CN (1) CN101516373B (ru)
AT (1) ATE468854T1 (ru)
AU (1) AU2007270910B2 (ru)
BR (1) BRPI0713395A2 (ru)
CA (1) CA2656549C (ru)
CY (1) CY1110741T1 (ru)
DE (1) DE602007006813D1 (ru)
DK (1) DK2049113T3 (ru)
EA (1) EA016142B1 (ru)
HK (1) HK1131032A1 (ru)
HR (1) HRP20100465T1 (ru)
HU (1) HUP0600555A3 (ru)
IL (1) IL196315A (ru)
MA (1) MA30951B1 (ru)
MX (1) MX2009000243A (ru)
NZ (1) NZ574596A (ru)
PL (1) PL2049113T3 (ru)
PT (1) PT2049113E (ru)
RS (1) RS51429B (ru)
SI (1) SI2049113T1 (ru)
WO (1) WO2008004013A2 (ru)
ZA (1) ZA200900507B (ru)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9602763A3 (en) * 1996-10-09 1999-05-28 Egyt Gyogyszervegyeszeti Gyar 3-phenyl isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
AU7547100A (en) * 1999-09-09 2001-04-10 Egis Gyogyszergyar Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
HU225955B1 (en) * 2001-07-26 2008-01-28 Egis Gyogyszergyar Nyilvanosan Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
US20030024849A1 (en) * 2001-07-26 2003-02-06 Nielsen Jacob Sturich Package for blister pack strips
HU227118B1 (en) * 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
HU227255B1 (en) * 2002-04-26 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Novel piperidine-alkyl-amino-pyridazine derivatives, pharmaceutical compositions containing the same and process for the preparation of the active ingredient

Also Published As

Publication number Publication date
US20100075975A1 (en) 2010-03-25
WO2008004013A2 (en) 2008-01-10
BRPI0713395A2 (pt) 2012-04-17
HK1131032A1 (en) 2010-01-15
AU2007270910B2 (en) 2012-08-09
IL196315A (en) 2014-09-30
NZ574596A (en) 2012-12-21
ATE468854T1 (de) 2010-06-15
JP2009542614A (ja) 2009-12-03
EP2049113B8 (en) 2010-11-03
CA2656549A1 (en) 2008-01-10
WO2008004013A8 (en) 2009-07-02
KR101465415B1 (ko) 2014-11-26
CN101516373B (zh) 2012-09-12
MX2009000243A (es) 2009-07-22
HUP0600555A3 (en) 2008-10-28
MA30951B1 (fr) 2009-12-01
EP2049113B1 (en) 2010-05-26
AU2007270910A1 (en) 2008-01-10
DK2049113T3 (da) 2010-08-16
KR20090091686A (ko) 2009-08-28
EA016142B1 (ru) 2012-02-28
CA2656549C (en) 2014-07-22
IL196315A0 (en) 2009-09-22
DE602007006813D1 (de) 2010-07-08
RS51429B (en) 2011-04-30
HUP0600555A2 (en) 2008-09-29
CY1110741T1 (el) 2014-02-12
JP5174018B2 (ja) 2013-04-03
EP2049113A2 (en) 2009-04-22
PT2049113E (pt) 2010-08-26
WO2008004013A3 (en) 2008-04-03
HU0600555D0 (en) 2006-09-28
ZA200900507B (en) 2010-05-26
PL2049113T3 (pl) 2011-02-28
US8318743B2 (en) 2012-11-27
CN101516373A (zh) 2009-08-26
SI2049113T1 (sl) 2010-10-29
HRP20100465T1 (hr) 2010-10-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU